Table 5 Potential drug-drug interaction analysis based on adverse event reports of thrombocytopenia

Acetaminophen

125

15,488

166.5

-0.41 (-0.67– -0.16)

N

0

N

0.51

N

0.81

N

Acetylsalicylic acid

73

9,119

109.25

-0.58 (-0.91– -0.25)

N

0

N

0.43

N

0.8

N

Ibuprofen

67

4,255

31.32

1.08 (0.74–1.43)

P

0.01

P

2.08

P

1.57

N

Celecoxib

66

8,481

106

-0.68 (-1.03– -0.33)

N

0

N

0.39

N

0.77

N

Diclofenac

66

6,579

84.63

-0.36 (-0.7– -0.01)

N

0

N

0.49

N

1

N

Naproxen

56

5,598

46.11

0.28 (-0.1–0.66)

N

0

N

1.06

P

0.99

N

Loxoprofen

43

1,280

44.01

-0.03 (-0.46–0.4)

N

0

N

0.47

N

1.03

N

Ketorolac

39

219

2.01

3.98 (3.52–4.43)

P

0.17

P

15.15

P

1.84

N

Meloxicam

27

4,569

42.49

-0.64 (-1.19– -0.1)

N

0

N

0.5

N

0.58

N

Indometacin

20

869

16.19

0.3 (-0.34–0.93)

N

0

N

0.68

N

1.19

N

Rofecoxib

14

1,265

15.13

-0.11 (-0.86–0.65)

N

0

N

0.61

N

1.09

N

Ketoprofen

8

829

22.59

-1.44 (-2.44– -0.44)

N

-0.02

N

0.18

N

0.61

N

Sulindac

7

439

6.64

0.07 (-1–1.14)

N

0

N

0.62

N

1.17

N

Etodolac

4

906

8.29

-0.97 (-2.38–0.45)

N

0

N

0.38

N

0.43

N

Piroxicam

4

431

4.25

-0.08 (-1.49–1.34)

N

0

N

0.7

N

0.91

N

Mefenamic acid

4

129

1.9

0.91 (-0.51–2.32)

N

0.02

P

1.25

P

1.39

N

Flurbiprofen

3

181

8.02

-1.28 (-2.92–0.35)

N

-0.03

N

0.17

N

0.63

N

Lornoxicam

3

93

1.66

0.69 (-0.94–2.33)

N

0.01

P

1

N

1.34

N

Oxaprozin

1

159

1.18

-0.16 (-2.99–2.66)

N

0

N

–

N

0.62

N

Aceclofenac

1

134

6.48

-2.22 (-5.05–0.61)

N

-0.04

N

0.07

N

0.33

N

Zaltoprofen

1

55

3.27

-1.33 (-4.16–1.5)

N

-0.04

N

0.14

N

0.55

N

Tenoxicam

1

40

0.3

0.91 (-1.92–3.74)

N

0.02

P

–

N

2.03

N