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Table 3 The equations and criteria for the algorithm

From: Pharmacovigilance study of BCR-ABL1 tyrosine kinase inhibitors: a safety analysis of the FDA adverse event reporting system

Algorithms

Equation

Criteria

ROR

ROR= (a×d) / (b×c)

lower limit of the 95% CI > 1 and a ≥ 3

95%CI = eln(ROR)±1.96 × (1/a+1/b+1/c+1/d)∧0.5

PRR

PRR= [a×(c + d)] / [c×(a + b)]

PRR ≥ 2, χ2 ≥ 4, and a ≥ 3

χ2= [(a×d − b×c)2]×(a + b + c + d) /[(a + b)×(c + d)×(a + c)×(b + d)]

  1. ROR, reporting odds ratio; PRR, proportional reporting ratio; CI, confidence interval; χ2, chi-squared
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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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