Table 4 Characteristics of AE reports for different BCR-ABL1 TKIs
Characteristics | Imatinib | Nilotinib | Dasatinib | Bosutinib | Ponatinib | All BCR-ABL1 TKIs |
|---|---|---|---|---|---|---|
Number of events | 39,746 | 17,351 | 19,633 | 3978 | 5281 | 85,989 |
Age (year), n (%) | ||||||
< 18 | 659 (1.66) | 75 (0.43) | 270 (1.38) | 5 (0.13) | 39 (0.74) | 1048 (1.22) |
18–44 | 3293 (8.29) | 1635 (9.42) | 2059 (10.49) | 391 (9.83) | 565 (10.70) | 7943 (9.24) |
45–64 | 6504 (16.36) | 3064 (17.66) | 4537 (23.11) | 1169 (29.39) | 916 (17.35) | 16,190 (18.83) |
65–74 | 3558 (8.95) | 1614 (9.30) | 2196 (11.19) | 809 (20.34) | 498 (9.43) | 8675 (10.09) |
≥ 75 | 2961 (7.45) | 1129 (6.51) | 1509 (7.69) | 714 (17.95) | 354 (6.70) | 6667 (7.75) |
Unknown | 22,771 (57.29) | 9834 (56.68) | 9062 (46.16) | 890 (22.37) | 2909 (55.08) | 45,466 (52.87) |
Median (IQR) | 60 (46, 71) | 59 (46, 70) | 59 (47, 69) | 64 (53, 74) | 44 (58, 69) | 60 (46, 70) |
Gender, n (%) | ||||||
Female | 16,898 (42.51) | 7326 (42.22) | 9226 (46.99) | 1803 (45.32) | 2037 (38.57) | 37,290 (43.37) |
Male | 19,419 (48.86) | 8310 (47.89) | 8745 (44.54) | 1770 (44.49) | 2523 (47.78) | 40,767 (47.41) |
Unknown | 3429 (8.63) | 1715 (9.88) | 1662 (8.47) | 405 (10.18) | 721 (13.65) | 7932 (9.22) |
Reported region, n (%) | ||||||
North America | 13,109 (32.98) | 7120 (41.04) | 16,995 (86.56) | 3311 (83.23) | 3673 (69.55) | 44,208 (51.41) |
Asia | 8279 (20.83) | 2992 (17.24) | 961 (4.89) | 296 (7.44) | 702 (13.29) | 13,230 (15.39) |
Europe | 4476 (11.26) | 2395 (13.80) | 1230 (6.26) | 315 (7.92) | 677 (12.82) | 9093 (10.57) |
South America | 852 (2.14) | 538 (3.10) | 220 (1.12) | 41 (1.03) | 147 (2.78) | 1798 (2.09) |
Africa | 878 (2.21) | 153 (0.88) | 67 (0.34) | 14 (0.35) | 30 (0.57) | 1142 (1.33) |
Oceania | 630 (1.59) | 241 (1.39) | 112 (0.57) | 1 (0.03) | 42 (0.80) | 1026 (1.19) |
Unknown | 11,522 (28.99) | 3912 (22.55) | 48 (0.24) | 0 (0) | 10 (0.19) | 15,492 (18.02) |
Outcome of AEs, n (%) | ||||||
Other outcomes | 11,433 (28.77) | 5249 (30.25) | 4586 (23.36) | 805 (20.24) | 1326 (25.11) | 23,399 (27.21) |
Death | 15,660 (39.40) | 3634 (20.94) | 1884 (9.60) | 375 (9.43) | 1694 (32.08) | 23,247 (27.03) |
Hospitalization (initial or prolonged) | 4796 (12.07) | 2832 (16.32) | 3546 (18.06) | 626 (15.74) | 1655 (31.34) | 13,455 (15.65) |
Life-threatening | 569 (1.43) | 370 (2.13) | 339 (1.73) | 34 (0.85) | 75 (1.42) | 1387 (1.61) |
Disability | 287 (0.72) | 145 (0.84) | 64 (0.33) | 9 (0.23) | 18 (0.34) | 523 (0.61) |
Unknown | 7001 (17.61) | 5121 (29.51) | 9214 (46.93) | 2129 (53.52) | 513 (9.71) | 23,978 (27.88) |