Pharmacokinetics and bioequivalence evaluation of two oral formulations of cotrimoxazole tablets in healthy Chinese volunteers under fasting conditions

Table 3 Bioequivalence analysis Under the Fasting Study

Group	Parameter (units)	GM		GMR	CV%	90% CI
Group	Parameter (units)	Test	Reference	(Test/Reference) %	CV%	90% CI
Sulfamethoxazole N = 26	C_max (ng/mL)	28997.53	26636.93	108.86	9.6	104.03%~113.92%
	AUC_0 − t (ng·h/mL)	327608.67	320972.67	102.07	3.34	100.46%~103.70%
	AUC_0−∞ (ng·h/mL)	336265.40	329377.49	102.09	3.51	100.41%~103.81%
Trimethoprim N = 26	C_max (ng/mL)	870.61	848.09	102.66	8.65	98.54%~106.95%
	AUC_0 − t (ng·h/mL)	8141.70	7873.25	103.41	8.53	99.31%~107.68%
	AUC_0−∞ (ng·h/mL)	8309.77	8033.24	103.44	8.21	99.49%~107.55%

C_max, maximum plasma drug concentration; AUC_0 − t, area under the plasma concentration-time curve from time 0 to the last measurable concentration; AUC_0−∞, area under the plasma concentration-time curve from time 0 to infinity; CV%, intrasubject coefficient of variation; GM, geometric mean; GMR, geometric mean ratio; N(T), number of healthy subjects in test drug treated group; N(R), number of healthy subjects in reference drug treated group

ISSN: 2050-6511