Fig. 4

H&E- stained Submandibular gland sections of albino rats (X400). (A) group C (B) group H (C) group U showing normal acinar architecture (circle), intact intercalated duct (ICD), striated duct (SD), and granular convoluted tubule (GCT) (D-E) group RF showing (D) Acinar cells with cytoplasmic vacuolation (red arrows) and nuclear pyknosis (chevrons), completely degenerated acini with shedding of the nuclei into the lumina (red circles), interacinar hemorrhage (yellow arrows), completely degenerated (ICD) with shedding of their cells into the lumina, (SD) lost the normal arrangement of the ductal cells with some nuclei appeared flattened and with polymorphism, and degenerated (GCT) with sloughing of their epithelial lining into the lumina. (E) Several acini appeared without demarcation between their cells (red circle), interacinar spaces (yellow arrows), completely degenerated (ICD) with shedding of their cells into the lumina; lost the normal arrangement of the ductal cells in (SD) and (GCT) with sloughing of their epithelial lining into the lumina leaving empty spaces around them with some nuclei appearing pyknotic, flattened and polymorphic. (F-G) group RFH and (H-I) group RFU showing partial preservation of the normal architecture (F-H) Acinar cells with small areas of acinar cell vacuolation (yellow arrow), some nuclei appeared to be normal vesicular (red chevron) others still pyknotic (yellow chevron), a decreased incidence of interacinar hemorrhage (red arrow), some (ICD), (SD) appeared with nearly normal architecture, some intact epithelial cells with vesicular nuclei while others ICD (yellow circle) SD (red circle) still degenerated with cellular disruption. (G-I) Few Interacinar spaces (yellow arrow) and some GCTs returned nearly normal while others (yellow circle) still degenerated