Risk of CKD among patients with DM taking diuretics or SGLT2i: a retrospective cohort study in Taiwan

Table 4 IR and aHR of CKD/ESRD associated with SGLT2i and diuretics use in patients with DM

SGLT2i or diuretics	Event	PY	IR	aHR (95% CI)
Neither	40	4,020	9.95	1 (Reference)
Diuretics only	99	3,272	30.26	2.46 (1.68, 3.61)***	1 (Reference)
Both	48	3,387	14.17	1.1 (0.71, 1.7)	0.45 (0.32, 0.63)***	1 (Reference)
SGLT2i only	27	4,154	6.5	0.64 (0.39, 1.04)	0.26 (0.17, 0.40)***	0.58 (0.36, 0.94)*

aHR, adjusted hazard ratio; CI, confidence interval; CKD, chronic kidney disease; DM, diabetes mellitus; ESRD, end-stage renal disease; event, number of patients with CKD; IR, incidence rate (per 1000 person-year); PY, person-years; SGLT2i, sodium-glucose cotransporter-2 inhibitors; *p < 0.05, **p < 0.01, ***p < 0.001

ISSN: 2050-6511