Fig. 1

Effects of dapagliflozin on body weight and glycolipid metabolism in mice. (A) Schematic study plan. 4–5 weeks old, male C57BL/6 mice with similar body weights were fed with normal chow diet (CD) or high fat diet (HFD). After 6weeks, mice in HFD + Dapa group were intragastrically administered with 1 mg /kg /day dapagliflozin (Dapa) for 9 weeks, mice in other groups were treated with 0.5% sodium carboxyl methyl cellulose solution as controls. (B) Body weight change. (C) The effect of 9 weeks of intragastric administration of Dapa on food intake. (D) Liver weight. (E) Levels of fasting blood glucose (FBG). (F–H) Levels of insulin, FFA and TG in serum. (n = 5). Values are mean ± SEM. *, P < 0.05