Fig. 6
From: Effects of nicotine on microRNA-124 expression in bile duct ligation-induced liver fibrosis in rats
The nicotine or saline was treated in sham or bile duct ligated rats and then the expression level of chemokine ligand 2 (CCL-2) was evaluated using RT-qPCR assay. ** P < 0.01, in comparison with corresponding sham-operated group and & P < 0.05 in comparison with the bile duct ligated-saline group. Also, the effects of bile duct ligation, as well as administration with nicotine (10 mg/kg) on the mRNA expression of signal transducer and activator of transcription 3 (STAT-3), were evaluated using RT-qPCR assay. Data are shown as Mean ± SEM and analyzed by one-way ANOVA and Tukey’s post-test. *** P < 0.001 in comparison with corresponding sham-operated group and & P < 0.05 in comparison with the bile duct ligated-saline group (N = 6, duplicate determinations)