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Volume 20 Supplement 1

Proceedings of Toxi-Latin 2018

Research

Publication of this supplement has not been supported by sponsorship. Information about the source of funding for publication charges can be found in the individual articles. The articles have undergone the journal's standard peer review process for supplements. Reviews of papers authored by NB and SCG were handled by DSA. No other competing interests were declared.

Porto Alegre, Brazil3-6 June 2018

Edited by Natália Brucker, Daiana Silva de Ávila and Solange Cristina Garcia


  1. Melatonin has been described in the literature as a potent antioxidant. However, melatonin presents variable, low bioavailability and a short half-life. The use of polymeric nanoparticulated systems has been p...

    Authors: Mariele F. Charão, Gabriela Goethel, Natália Brucker, Karina Paese, Vera L. Eifler-Lima, Adriana R. Pohlmann, Silvia S. Guterres and Solange C. Garcia

    Citation: BMC Pharmacology and Toxicology 2019 20(Suppl 1):80

    Content type: Research

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  2. Ultraviolet (UV) radiation is the main exogenous inductor of skin damage and so photoprotection is important to control skin disorders. The Antarctic moss Sanionia uncinata is an important source of antioxidants ...

    Authors: Andréia da Silva Fernandes, Lara Barroso Brito, Gisele Augusto Rodrigues Oliveira, Elisa Raquel Anastácio Ferraz, Heitor Evangelista, José Luiz Mazzei and Israel Felzenszwalb

    Citation: BMC Pharmacology and Toxicology 2019 20(Suppl 1):77

    Content type: Research

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  3. The presence of impurities in some drugs may compromise the safety and efficacy of the patient’s treatment. Therefore, establishing of the biological safety of the impurities is essential. Diabetic patients ar...

    Authors: Camila F. A. Giordani, Sarah Campanharo, Nathalie R. Wingert, Lívia M. Bueno, Joanna W. Manoel, Barbara Costa, Shanda Cattani, Marcelo Dutra Arbo, Solange Cristina Garcia, Cássia Virginia Garcia, Nádia Maria Volpato, Elfrides Eva Scherman Schapoval and Martin Steppe

    Citation: BMC Pharmacology and Toxicology 2019 20(Suppl 1):82

    Content type: Research

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  4. Nickel and nickel-containing compounds (NCC) are known human carcinogens. However, the precise molecular mechanisms of nickel-induced malignant transformation remain unknown. Proposed mechanisms suggest that n...

    Authors: Luisa Jiménez-Vidal, Pedro Espitia-Pérez, José Torres-Ávila, Dina Ricardo-Caldera, Shirley Salcedo-Arteaga, Claudia Galeano-Páez, Karina Pastor-Sierra and Lyda Espitia-Pérez

    Citation: BMC Pharmacology and Toxicology 2019 20(Suppl 1):78

    Content type: Research

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  5. Gasoline is a complex mixture of saturated and unsaturated hydrocarbons, in which aromatic compounds, such as BTX (benzene, toluene, and xylene) feature as the main constituents. Simultaneous exposure to these...

    Authors: Angela Maria Moro, Elisa Sauer, Natália Brucker, Mariele Feiffer Charão, Bruna Gauer, Sabrina Nunes do Nascimento, Gabriela Goethel, Marta Maria Medeiros Frescura Duarte and Solange Cristina Garcia

    Citation: BMC Pharmacology and Toxicology 2019 20(Suppl 1):75

    Content type: Research

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  6. Exposure to vinylcyclohexene (VCH) and methylmercury (MeHg+) can induce oxidative stress and gene modulation. Several studies have been evaluating the effects of VCH and MeHg+, but little is known about interacti...

    Authors: Bruna Candia Piccoli, Ana Lúcia Anversa Segatto, Cláudia Sirlene Oliveira, Fernanda D’Avila da Silva, Michael Aschner and João Batista Teixeira da Rocha

    Citation: BMC Pharmacology and Toxicology 2019 20(Suppl 1):83

    Content type: Research

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  7. Chagas disease (CD) is a tropical parasitic disease. Although the number of people infected is very high, the only drugs available to treat CD, nifurtimox (Nfx) and benznidazole, are highly toxic, particularly...

    Authors: Fabiana Gomes Nascimento Soares, Gabriela Göethel, Luciano Porto Kagami, Gustavo Machado das Neves, Elisa Sauer, Estefania Birriel, Javier Varela, Itamar Luís Gonçalves, Gilsane Von Poser, Mercedes González, Daniel Fábio Kawano, Fávero Reisdorfer Paula, Eduardo Borges de Melo, Solange Cristina Garcia, Hugo Cerecetto and Vera Lucia Eifler-Lima

    Citation: BMC Pharmacology and Toxicology 2019 20(Suppl 1):76

    Content type: Research

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  8. Tamoxifen is considered a prodrug of its active metabolite endoxifen, which is dependent on the CYP2D6 and CYP3A enzymes. Tamoxifen pharmacokinetic variability influences endoxifen exposure and, consequently, ...

    Authors: João Paulo Bianchi Ximenez, Jurandyr Moreira de Andrade, Maria Paula Marques, Eduardo Barbosa Coelho, Guilherme Suarez-Kurtz and Vera Lucia Lanchote

    Citation: BMC Pharmacology and Toxicology 2019 20(Suppl 1):81

    Content type: Research

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  9. The γ-hexalactone is a flavoring agent for alcoholic beverages, teas, breads, dairy products, coffees, buttery products among others. It presents low molecular weight and exhibits sweet fruity aroma with nuanc...

    Authors: Luísa Zuravski, Taiane A. Escobar, Elizandra G. Schmitt, Queila D. F. Amaral, Fávero R. Paula, Thiago Duarte, Marta M. M. F. Duarte, Michel M. Machado, Luís F. S. Oliveira and Vanusa Manfredini

    Citation: BMC Pharmacology and Toxicology 2019 20(Suppl 1):79

    Content type: Research

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