Skip to main content

Articles

Page 1 of 20

  1. Preconditioning of the heart ameliorates doxorubicin (Dox)-induced cardiotoxicity. We tested whether pretreating cardiomyocytes by mitochondrial-targeted antioxidants, mitoquinone (MitoQ) or SKQ1, would provid...

    Authors: Brian Sacks, Halil Onal, Rose Martorana, Amogh Sehgal, Amanda Harvey, Catherine Wastella, Hafsa Ahmad, Erin Ross, Adona Pjetergjoka, Sachin Prasad, Robert Barsotti, Lindon H. Young and Qian Chen

    Citation: BMC Pharmacology and Toxicology 2021 22:49

    Content type: Research article

    Published on:

  2. Aidi Injection (ADI), a Chinese herbal preparation with anti-cancer activity, is used for the treatment of hepatocellular carcinoma (HCC). Several clinical studies have shown that co-administration of ADI with...

    Authors: Yuan Lu, Jie Pan, Xiaoqing Zhu, Shuai Zhang, Chunhua Liu, Jia Sun, Yueting Li, Siying Chen, Jing Huang, Chuang Cao, Yonglin Wang, Yongjun Li and Ting Liu

    Citation: BMC Pharmacology and Toxicology 2021 22:48

    Content type: Research article

    Published on:

  3. Acute kidney injury (AKI) is associated with significant increases in short- and long-term morbidity and mortality. Drug-induced AKI is a major concern in the present healthcare system. Our spontaneous reporti...

    Authors: Satoshi Nakao, Shiori Hasegawa, Ryogo Umetsu, Kazuyo Shimada, Ririka Mukai, Mizuki Tanaka, Kiyoka Matsumoto, Yu Yoshida, Misaki Inoue, Riko Satake, Yuri Nishibata, Jun Liao and Mitsuhiro Nakamura

    Citation: BMC Pharmacology and Toxicology 2021 22:47

    Content type: Research article

    Published on:

  4. Antiretroviral drugs (ARVs) have significantly reduced morbidity, mortality and improved the quality of life of people living with HIV infection. Poor quality ARVs may result in harmful consequences such as ad...

    Authors: Sophia Mziray, Betty A. Maganda, Kissa Mwamwitwa, Adam M. Fimbo, Seth Kisenge, Gerald Sambu, Yonah H. Mwalwisi, Adonis Bitegeko, Emmanuel Alphonce, Akida Khea, Danstan H. Shewiyo and Eliangiringa Kaale

    Citation: BMC Pharmacology and Toxicology 2021 22:46

    Content type: Research article

    Published on:

  5. Abnormally elevated xanthine oxidase (XO) activity has been verified to cause various pathological processes, such as gout, oxidative stress injury and metabolic syndrome. Thus, XO activators may exhibit above...

    Authors: Liang Yue, Nan Jiang, Anguo Wu, Wenqiao Qiu, Xin Shen, Dalian Qin, Hong Li, Jing Lin, Sicheng Liang and Jianming Wu

    Citation: BMC Pharmacology and Toxicology 2021 22:45

    Content type: Research

    Published on:

  6. Helicobacter pylori (H. pylori) is a common pathogen in development of peptic ulcers with pyroptosis. Rabeprazole, a critical component of standard triple therapy, has been widely used as the first-line regimen f...

    Authors: Jing Xie, Long Fan, Liya Xiong, Peiyu Chen, Hongli Wang, Huan Chen, Junhong Zhao, Zhaohui Xu, Lanlan Geng, Wanfu Xu and Sitang Gong

    Citation: BMC Pharmacology and Toxicology 2021 22:44

    Content type: Research

    Published on:

  7. Esculetin is a natural coumarin derivative from various plants with multiple pharmacological effects. Hence, the present study was undertaken to explore the cardio protective potential of esculetin against iso...

    Authors: Chitikela P. Pullaiah, Vinod K. Nelson, Sushma Rayapu, Narasimha Kumar G V and Thyagaraju Kedam

    Citation: BMC Pharmacology and Toxicology 2021 22:43

    Content type: Research

    Published on:

  8. Melittin is one of the most studied antimicrobial peptides, and several in vitro experiments have demonstrated its antibacterial efficacy. However, there is evidence showing melittin has non-promising effects suc...

    Authors: Parvin Askari, Mohammad Hasan Namaei, Kiarash Ghazvini and Mehran Hosseini

    Citation: BMC Pharmacology and Toxicology 2021 22:42

    Content type: Research

    Published on:

  9. Recently, the development of nanocarriers and the improvement of their biochemical properties have became of great importance. Single-walled carbon nanotubes (SWCNT) have many applications in drug delivery sys...

    Authors: Mohammad Dahri, Hossein Akbarialiabad, Ahmad Miri Jahromi and Reza Maleki

    Citation: BMC Pharmacology and Toxicology 2021 22:41

    Content type: Research article

    Published on:

  10. Ethnic differences in testicular cancer rates (TCRs) are recognized internationally. Cannabis is a known risk factor for testicular cancer (TC) in multiple studies with dose-response effects demonstrated, howe...

    Authors: Albert Stuart Reece and Gary Kenneth Hulse

    Citation: BMC Pharmacology and Toxicology 2021 22:40

    Content type: Research

    Published on:

  11. The present study investigated the ameliorative effect of melittin, a major polypeptide in the venom of honeybee (Apis mellifera), on isoniazid-(INH) and rifampicin-(RIF) induced hepatotoxicity in male albino rat...

    Authors: Khalid Mohammed Naji, Bushra Yahya Al-Khatib, Nora Saif Al-Haj and Myrene R. D’souza

    Citation: BMC Pharmacology and Toxicology 2021 22:39

    Content type: Research article

    Published on:

  12. Subtilisin QK is a serine protease in the subtilisin family, and is fermented by Bacillus subtilis QK02. The fibrinolytic activity of subtilisin QK was measured by detecting low molecular weight degradation produ...

    Authors: Shuai Xiao, Dingbang Hu, Ya Gao, Yang Ai, Sang Luo, Song Chen, Ben Wang, Li Zhou, Yanshan Dong and Yefu Wang

    Citation: BMC Pharmacology and Toxicology 2021 22:38

    Content type: Research

    Published on:

  13. Authors: Nahum Méndez-Sánchez, Miguel Dibildox-Martinez, Jahir Sosa-Noguera, Ramón Sánchez-Medal and Francisco J. Flores-Murrieta

    Citation: BMC Pharmacology and Toxicology 2021 22:37

    Content type: Correction

    Published on:

    The original article was published in BMC Pharmacology and Toxicology 2019 20:5

  14. Drug-induced toxicity is one of the problems that have negatively impacted on the well-being of populations throughout the world, including Malawi. It results in unnecessary hospitalizations, retarding the dev...

    Authors: Ibrahim Chikowe, Alfred Chipanda Phiri, Kirios Patrick Mbewe and Dunstan Matekenya

    Citation: BMC Pharmacology and Toxicology 2021 22:36

    Content type: Research

    Published on:

  15. Chronic post-surgical pain (CPSP) has a negative impact on the recovery, quality of life, and physical functioning of elderly patients. This study aimed to test the superiority of parecoxib vs. placebo in prev...

    Authors: Xiaodong Ge, Yan Pan, Danfeng Jin, Ying Wang and Shengjin Ge

    Citation: BMC Pharmacology and Toxicology 2021 22:35

    Content type: Research article

    Published on:

  16. Patients with type 2 diabetes mellitus (T2DM) are characterized by an elevated glycemic index and are at a higher risk for complications such as cardiovascular disease, nephropathy, retinopathy and peripheral ...

    Authors: Robert Dobbins, Elizabeth K. Hussey, Robin O’Connor-Semmes, Susan Andrews, Wenli Tao, William O. Wilkison, Bentley Cheatham, Katare Sagar and Barkate Hanmant

    Citation: BMC Pharmacology and Toxicology 2021 22:34

    Content type: Research article

    Published on:

  17. The objective of the present study was to determine the effect of allisartan, a new angiotensin II type 1 receptor antagonist on vascular remodeling through voltage gated potassium channels (Kv7) in hypertensi...

    Authors: Xiaoqin Zhang, Ziying Zhao, Chunfang Xu, Fengping Zhao and Zhiqiang Yan

    Citation: BMC Pharmacology and Toxicology 2021 22:33

    Content type: Research

    Published on:

  18. Acinetobacter baumannii is an opportunistic pathogen that can cause several kinds of nosocomial infections. Increasing antibiotic resistance as well as identifying genetic diversity and factors associated with pa...

    Authors: Maryam Hazhirkamal, Omid Zarei, Mahsa Movahedi, Pezhman Karami, Leili Shokoohizadeh and Mohammad Taheri

    Citation: BMC Pharmacology and Toxicology 2021 22:32

    Content type: Research

    Published on:

  19. The aim of this study is to examine the association of hypophosphatemia and hyperphosphatemia on the first day of ICU admission with mortality in septic critically ill patients.

    Authors: Shmeylan A. Al Harbi, Hasan M. Al-Dorzi, Albatool M. Al Meshari, Hani Tamim, Sheryl Ann I. Abdukahil, Musharaf Sadat and Yaseen Arabi

    Citation: BMC Pharmacology and Toxicology 2021 22:30

    Content type: Research article

    Published on:

  20. Drug potency is a pharmacological parameter defining dose or concentration of drug required to obtain 50% of the drug’s maximal effect. Pharmacokinetic-pharmacodynamic modelling and simulation allows estimatio...

    Authors: Bernard Ngara, Simbarashe Zvada, Tariro Dianah Chawana, Charles Fungai Brian Nhachi and Simbarashe Rusakaniko

    Citation: BMC Pharmacology and Toxicology 2021 22:29

    Content type: Research article

    Published on:

  21. Doxorubicin (DOX) is widely used as an effective chemotherapeutic agent for cancers; however, DOX induces cardiac toxicity, called DOX-induced cardiomyopathy. Although DOX-induced cardiomyopathy is known to be...

    Authors: Takaaki Furihata, Satoshi Maekawa, Shingo Takada, Naoya Kakutani, Hideo Nambu, Ryosuke Shirakawa, Takashi Yokota and Shintaro Kinugawa

    Citation: BMC Pharmacology and Toxicology 2021 22:27

    Content type: Research

    Published on:

  22. We aim to develop a population pharmacokinetics (PopPK) model of vancomycin for the treatment of septicemia in infants younger than one year. Factors influence of the PK was investigated to optimize vancomycin...

    Authors: Zhiling Li, Hongjing Li, Chenyu Wang, Zheng Jiao, Feng Xu and Huajun Sun

    Citation: BMC Pharmacology and Toxicology 2021 22:26

    Content type: Research article

    Published on:

  23. There are no reports on the incidence of chronic mercury poisoning in a large population in China. This study investigated the epidemiology, clinical manifestations, treatment, and follow-up of Chinese patient...

    Authors: Sun Yawei, Long Jianhai, Zhao Junxiu, Peng Xiaobo and Qiu Zewu

    Citation: BMC Pharmacology and Toxicology 2021 22:25

    Content type: Research article

    Published on:

  24. Surgical procedures cause perioperative immunosuppression and neuroendocrine stress, exerted by activation of the autonomic nervous system and the hypothalamic-pituitary-adrenal axis. The acetylcholinesterase ...

    Authors: Mennatallah A Gowayed, Amany Abdel-Bary and Rasha A El-Tahan

    Citation: BMC Pharmacology and Toxicology 2021 22:24

    Content type: Research article

    Published on:

  25. Taurochenodeoxycholic acid (TCDCA) is one of the major active components in bile acid. It was proven to have inhibitory activities on inflammation and also participate in host immuno-regulation. TCDCA exerts a...

    Authors: Lige Bao, Dacheng Hao, Xu Wang, Xiuling He, Wei Mao and Peifeng Li

    Citation: BMC Pharmacology and Toxicology 2021 22:23

    Content type: Research article

    Published on:

  26. Low dose of NP exposure can alter adipose tissue formation, and the intake of high-fat diet (HFD) can also lead to the fatty liver disease. We investigated the combined effect of NP and HFD on the first offspr...

    Authors: Hongyu Zhang, Chengguang Song, Rong Yan, Hongbo Cai, Yi Zhou and Xiaoyu Ke

    Citation: BMC Pharmacology and Toxicology 2021 22:22

    Content type: Research

    Published on:

  27. Bifenthrin is a pyrethroid. Chronic exposure of humans to the pesticide occurs. Reports about immunotoxicity and proinflammatory effect of pyrethroids were published. The aim of the article was to check if sub...

    Authors: Oktawia Pylak-Piwko and Barbara Nieradko-Iwanicka

    Citation: BMC Pharmacology and Toxicology 2021 22:21

    Content type: Research article

    Published on:

  28. A Proton Pump Inhibitor (PPI) de-escalation initiative was piloted at a Family Medicine Federally Qualified Health Center (FQHC) after a needs assessment showed that PPIs were prescribed inappropriately. The o...

    Authors: Joelle Ayoub, Jessina C. McGregor, Rebecca M. Castner and Harleen Singh

    Citation: BMC Pharmacology and Toxicology 2021 22:20

    Content type: Research article

    Published on:

  29. Arsenic poisoning affects millions of people. The inorganic forms of arsenic are more toxic. Treatment for arsenic poisoning relies on chelation of extracellularly circulating arsenic molecules by 2,3-dimecapt...

    Authors: Victoria K. Mwaeni, James N. Nyariki, Ngalla Jillani, George Omwenga, Mathew Ngugi and Alfred Orina Isaac

    Citation: BMC Pharmacology and Toxicology 2021 22:19

    Content type: Research article

    Published on:

  30. Vitamin D deficiency is prevalent in patients with non-alcoholic fatty liver disease (NAFLD), but there are debates on the usefulness of vitamin D treatment. The interindividual variations in response may be d...

    Authors: Hamid Yaghooti, Fatemeh Ghanavati, Seyed Saeed Seyedian, Bahman Cheraghian and Narges Mohammadtaghvaei

    Citation: BMC Pharmacology and Toxicology 2021 22:18

    Content type: Research article

    Published on:

  31. Musculoskeletal side effects related to isotretinoin are frequently reported. This study aimed to investigate the effect of oral isotretinoin treatment on muscle strength. Our second aim was to evaluate whethe...

    Authors: Cevriye Mülkoğlu and Nermin Karaosmanoğlu

    Citation: BMC Pharmacology and Toxicology 2021 22:17

    Content type: Research article

    Published on:

  32. Bupivacaine blocks many ion channels in the heart muscle, causing severe cardiotoxicity. Small-conductance calcium-activated potassium type 2 channels (SK2 channels) are widely distributed in the heart cells a...

    Authors: Hongfei Chen, Zhousheng Jin, Fangfang Xia and Zhijian Fu

    Citation: BMC Pharmacology and Toxicology 2021 22:15

    Content type: Research article

    Published on:

  33. The impact of prior exposure to systemic corticosteroids on COVID-19 severity in patients hospitalized for a SARS-CoV-2 pneumonia is not known. The present study was designed to answer to this question.

    Authors: Margaux Lafaurie, Guillaume Martin-Blondel, Pierre Delobel, Nassim Kamar, Sandrine Charpentier, Agnès Sommet and Guillaume Moulis

    Citation: BMC Pharmacology and Toxicology 2021 22:14

    Content type: Research article

    Published on:

  34. Linezolid is administered as a fixed dose to all patients despite evidence of overexposure and thrombocytopenia in renal impairment. The aims of this study were to evaluate the risk of thrombocytopenia and the...

    Authors: Hitoshi Kawasuji, Yasuhiro Tsuji, Chika Ogami, Kou Kimoto, Akitoshi Ueno, Yuki Miyajima, Koyomi Kawago, Ippei Sakamaki and Yoshihiro Yamamoto

    Citation: BMC Pharmacology and Toxicology 2021 22:13

    Content type: Research article

    Published on:

  35. Poor quality medicines have serious implications for public health. The aim of this study was to explore the quality of the antidiabetic pioglitazone, using samples collected in China and Myanmar, and samples ...

    Authors: Mohammad Sofiqur Rahman, Naoko Yoshida, Hirohito Tsuboi, Erina Maeda, Andrea Vanessa Velasco Ibarra, Theingi Zin, Yoshio Akimoto, Tsuyoshi Tanimoto and Kazuko Kimura

    Citation: BMC Pharmacology and Toxicology 2021 22:12

    Content type: Research article

    Published on:

  36. High-intensity statin therapy is typically used in patients with acute myocardial infarction (AMI) for secondary prevention. However, there have been consistent concerns regarding its association with diabetes...

    Authors: Jah Yeon Choi, Cheol Ung Choi, Byoung Geol Choi, Yoonjee Park, Dong Oh Kang, Won Young Jang, Woohyeun Kim, Jin Oh Na, Jin Won Kim, Eung Ju Kim, Seung-Woon Rha, Chang Gyu Park, Hong Seog Seo, Myung Ho Jeong, Sung-Chull Chae, In-Whan Seong…

    Citation: BMC Pharmacology and Toxicology 2021 22:11

    Content type: Research article

    Published on:

  37. Aryl-propionic acid derivatives with ibuprofen as representative drug are very important for therapy, being recommended especially for anti-inflammatory and analgesic effects. On other hand 1,3-thiazolidine-4-...

    Authors: Ioana-Mirela Vasincu, Maria Apotrosoaei, Sandra Constantin, Maria Butnaru, Liliana Vereștiuc, Cătălina-Elena Lupușoru, Frederic Buron, Sylvain Routier, Dan Lupașcu, Roxana-Georgiana Taușer and Lenuța Profire

    Citation: BMC Pharmacology and Toxicology 2021 22:10

    Content type: Research article

    Published on:

  38. Emodin, a natural anthraquinone, has shown potential as an effective therapeutic agent in the treatment of many diseases including cancer. However, its clinical development is hindered by uncertainties surroun...

    Authors: Alexander T. Sougiannis, Reilly T. Enos, Brandon N. VanderVeen, Kandy T. Velazquez, Brittany Kelly, Sierra McDonald, William Cotham, Ioulia Chatzistamou, Mitzi Nagarkatti, Daping Fan and E. Angela Murphy

    Citation: BMC Pharmacology and Toxicology 2021 22:9

    Content type: Research article

    Published on:

  39. Hormonal receptor positive (HR+) breast cancer is the most commonly diagnosed molecular subtype of breast cancer; which showed good response to doxorubicin (DOX)-based chemotherapy. Eugenol (EUG) and astaxanth...

    Authors: Mariam A. Fouad, Mohamed M. Sayed-Ahmed, Etimad A. Huwait, Hafez F. Hafez and Abdel-Moneim M. Osman

    Citation: BMC Pharmacology and Toxicology 2021 22:8

    Content type: Research article

    Published on:

  40. Oxidative damage to retinal pigment epithelial (RPE) cells contributes to the development of age-related macular degeneration, which is among the leading causes of visual loss in elderly people. In the present...

    Authors: Myung Hee Kim, Do-Hun Kim, Su Geun Yang and Dae Yu Kim

    Citation: BMC Pharmacology and Toxicology 2021 22:7

    Content type: Research article

    Published on:

  41. Vigabatrin (VGB) is an approved non-traditional antiepileptic drug that has been revealed to have potential for treating brain tumors; however, its effect on ionic channels in glioma cells remains largely uncl...

    Authors: Te-Yu Hung, Huai-Ying Ingrid Huang, Sheng-Nan Wu and Chin-Wei Huang

    Citation: BMC Pharmacology and Toxicology 2021 22:6

    Content type: Research article

    Published on:

  42. Acetaminophen (APAP) induced hepatotoxicity is a clinically important problem. Up to now, interventive therapy with n-acetylcysteine (NAC) has been considered as a gold-standard treatment for APAP overdose. Ho...

    Authors: Samaneh Nakhaee, Mohammad Dastjerdi, Hesam Roumi, Omid Mehrpour and Khadijeh Farrokhfall

    Citation: BMC Pharmacology and Toxicology 2021 22:4

    Content type: Research article

    Published on:

  43. Considering the limited generalizability of previous anticholinergic burden scales, the Korean Anticholinergic Burden Scale (KABS) as a scale specific to the Korean population was developed. We aimed to valida...

    Authors: Sunghee Hwang, Jee Eun Chung, Kwanghee Jun, Young-Mi Ah, Kwang-Il Kim and Ju-Yeun Lee

    Citation: BMC Pharmacology and Toxicology 2021 22:2

    Content type: Research article

    Published on:

  44. The development of novel and effective drugs for targeted human hepatocellular carcinoma still remains a great challenge. The alkaloid nitidine chloride (NC), a component of a traditional Chinese medicine, has...

    Authors: Danni Li, Shaogang Liu, Jiahao Zhu, Liqun Shen, Qi ying Zhang and Hua Zhu

    Citation: BMC Pharmacology and Toxicology 2021 22:1

    Content type: Research article

    Published on:

  45. A novel, high bioavailability oral, enteric coated tablet formulation of S-adenosylmethionine (MSI-195) has been developed for life science application. The present research reports on a Phase 1 study to (i) d...

    Authors: Beth R. Cameron, Ludvina Ferreira and I. David MacDonald

    Citation: BMC Pharmacology and Toxicology 2020 21:88

    Content type: Research article

    Published on:

Reviewer acknowledgments

Annual Journal Metrics