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  1. This bioequivalence study was conducted to evaluate two oral formulations of cotrimoxazole tablets in healthy Chinese subjects. All 26 subjects recruited to this study were randomly and evenly classified into ...

    Authors: Xu Zuo, Xin Zhao, Jinjin Shi and Tiandong Zhang
    Citation: BMC Pharmacology and Toxicology 2024 25:23
  2. Radiation triggers salivary gland damage and excess iron accumulates in tissues induces cell injury. Flavonoids are found in some fruits and are utilized as potent antioxidants and radioprotective agents. This...

    Authors: Salwa Farid Ahmed, Eman M. F. El-Maghraby, Maha M. Rashad and Dina W. Bashir
    Citation: BMC Pharmacology and Toxicology 2024 25:22
  3. This study aimed to design and evaluate the transdermal permeation of Huperzine A ethosomes gel in vitro. Huperzine A ethosomes were prepared using the injection method, and their physical and chemical propert...

    Authors: Jiyu Wu, Renai Xu, Xiaowei Xu, Shiyuan Ye and Aifang Huang
    Citation: BMC Pharmacology and Toxicology 2024 25:21
  4. With the increased use of BCR-ABL1 tyrosine kinase inhibitors (TKIs) in cancer patients, adverse events (AEs) have garnered considerable interest. We conducted this pharmacovigilance study to evaluate the AEs ...

    Authors: Dehua Zhao, Xiaoqing Long and Jisheng Wang
    Citation: BMC Pharmacology and Toxicology 2024 25:20
  5. Previous studies investigating the effect of oral supplementation of paricalcitol on reactive protein levels in chronic kidney disease (CKD) patients reported inconsistent findings. In this systematic review a...

    Authors: Seyyed Mostafa Arabi, Mostafa Shahraki-Jazinaki, Mahla Chambari, Leila Sadat Bahrami, Sara Sabeti, Mohammaed Ibrahim Mohaildeen Gubari, Basil D. Roufogalis and Amirhossein Sahebkar
    Citation: BMC Pharmacology and Toxicology 2024 25:19
  6. Pulmonary fibrosis is a chronic progressive disease with complex pathogenesis, short median survival time, and high mortality. There are few effective drugs approved for pulmonary fibrosis treatment. This stud...

    Authors: Yanjun Zeng, Rui Hu, Wei Ma, Ying Ding, Yi Zhou, Xin Peng, Lixin Feng, Qingmei Cheng and Ziqiang Luo
    Citation: BMC Pharmacology and Toxicology 2024 25:18
  7. Safinamide (SAF), an α-aminoamide derivative and a selective, reversible monoamine oxidase (MAO)-B inhibitor, has both dopaminergic and nondopaminergic (glutamatergic) properties. Several studies have explored...

    Authors: Te-Yu Hung, Sheng-Nan Wu and Chin-Wei Huang
    Citation: BMC Pharmacology and Toxicology 2024 25:17
  8. Critically ill COVID-19 and non-COVID-19 patients receive thromboprophylaxis with the LMWH nadroparin. Whether a standard dosage is adequate in attaining the target anti-FXa levels (0.20–0.50 IU/ml) in these g...

    Authors: Monique M.R. de Maat, Henk J. van Leeuwen, Lian Roovers, Sabine J.G.M. Ahlers, Jolanda Lambers and Marcel M.C. Hovens
    Citation: BMC Pharmacology and Toxicology 2024 25:16
  9. Zinc Gluconate (ZG) is a safe and effective supplement for zinc. However, there is limited research on the optimal dosage for intravenous injection and the safety evaluation of animal models for ZG. This study...

    Authors: Yong-cai Wang, Xia Yang, Juan Xiao, Su-mei Wei, Ying Su, Xiu-qi Chen, Ting Huang and Qing-wen Shan
    Citation: BMC Pharmacology and Toxicology 2024 25:15
  10. Uranium exposure may cause serious pathological injury to the body, which is attributed to oxidative stress and inflammation. However, the pathogenesis of uranium toxicity has not been clarified. Here, we eval...

    Authors: Yuwei Yang, Chunmei Dai, Xi Chen, Bin Zhang, Xiaohan Li, Wenyu Yang, Jun Wang and Jiafu Feng
    Citation: BMC Pharmacology and Toxicology 2024 25:14
  11. Methotrexate (MTX) is the cornerstone of rheumatoid arthritis (RA) treatment and is highly effective with low-dose intermittent administration. MTX is occasionally used in combination with non-steroidal anti-i...

    Authors: Takeshi Honma, Kenji Onda and Koichi Masuyama
    Citation: BMC Pharmacology and Toxicology 2024 25:13
  12. Postoperative nausea and vomiting (PONV) after total joint arthroplasty is common and associated with delayed recovery. This study was performed to evaluate the efficacy of three different prophylactic regimen...

    Authors: Jinwei Xie, Yingcun Cai and Fuxing Pei
    Citation: BMC Pharmacology and Toxicology 2024 25:12
  13. Convenience stores in Guatemala provide essential consumer goods in communities, but many dispense antibiotics illegally. Federal legislation, passed in August of 2019, requires prescriptions for antibiotic pu...

    Authors: N. Rojop, P. Moreno, L. Grajeda, J. Romero, L. Reynoso, E. Muñoz, G. H. Palmer, C. Cordón-Rosales, D. R. Call and B. M. Ramay
    Citation: BMC Pharmacology and Toxicology 2024 25:11
  14. Cantharidin (CTD), the main toxic component of Mylabris, has been extensively used for tumor treatment in recent years. CTD-induced liver toxicity has attracted significant interest in clinic.

    Authors: Shan Li, Xiaotong Duan, Yixin Zhang, Cancan Zhao, Ming Yu, Xiaofei Li, Xiaomei Li and Jianyong Zhang
    Citation: BMC Pharmacology and Toxicology 2024 25:10
  15. The Gram-negative bacterium Helicobacter pylori, H. pylori, is associated with significant digestive disorders. However, the effectiveness of bacterial eradication is declining due to drug resistance. A potent an...

    Authors: Kiarash Ghazvini, Hossein Kamali, Hadi Farsiani, Masoud Yousefi and Masoud Keikha
    Citation: BMC Pharmacology and Toxicology 2024 25:9
  16. We aimed to examine the efficiency of fixed daily dose enoxaparin (40 mg) thromboprophylaxis strategy for patients undergoing inpatient rehabilitation.

    Authors: Amir Haim, Orli Avnery, Deborah Rubin-Asher, Hagay Amir, Kaifa Hashem, Harel Ben Zvi and Motti Ratmansky
    Citation: BMC Pharmacology and Toxicology 2024 25:8
  17. To comprehend the influences of fenofibrate on hepatic lipid accumulation and mitochondrial function-related signaling pathways in mice with non-alcoholic fatty liver disease (NAFLD) secondary to high-fat diet...

    Authors: Xuemei Wang, Jieying Wang, Cao Ying, Yuan Xing, Xuan Su and Ke Men
    Citation: BMC Pharmacology and Toxicology 2024 25:7
  18. Definity is an ultrasound contrast agent consisting of phospholipids-encapsulated perfluoropropane (PFP), also known as perflutren, microspheres, which is initially designed to enhance echocardiographic ultras...

    Authors: Pengfei Li, Ping Du, Jun Peng, Zhixia Zhao, Huiling Li, Weiyue Yu, Shumin Wang and Lihong Liu
    Citation: BMC Pharmacology and Toxicology 2024 25:6
  19. Previous pharmacovigilance studies and a retroactive review of cancer clinical trial studies identified that women were more likely to experience drug adverse events (i.e., any unintended effects of medication...

    Authors: Jennifer L. Fisher, Amanda D. Clark, Emma F. Jones and Brittany N. Lasseigne
    Citation: BMC Pharmacology and Toxicology 2024 25:5
  20. This study aimed to develop a physiologically-based pharmacokinetic (PBPK) model to predict changes in the pharmacokinetics (PK) and pharmacodynamics (PD, PDE4 inhibition) of roflumilast (ROF) and ROF N-oxide ...

    Authors: Guangwei Jia, Congcong Ren, Hongyan Wang and Caixia Fan
    Citation: BMC Pharmacology and Toxicology 2024 25:4
  21. Multiple pesticides are often used in combination for plant protection and public health. Therefore, it is important to analyze the physiological changes induced by multiple pesticides exposure. The objective ...

    Authors: Yu-Jie Liang, Ding-Xin Long, Shanshan Wang, Hui-Ping Wang and Yi-Jun Wu
    Citation: BMC Pharmacology and Toxicology 2024 25:3
  22. Drug-drug interactions (DDIs) influence the effectiveness of medication and thus determine the treatment outcomes of diseases managed with pharmacotherapy. This study aimed to determine the prevalence, severit...

    Authors: Allan Phillip Lule, Ogwal Basil Delic, Keneth Katunguka, Francis Muwonge and Tadele Mekuriya Yadesa
    Citation: BMC Pharmacology and Toxicology 2024 25:2
  23. A connection between diabetes and an increased risk of epilepsy has been suggested by observational studies. Animal studies have also shown that antihyperglycemic drugs can improve seizures. However, it is unc...

    Authors: Kaiping Zhou, Huan Yang, Zhihao Xie, Weiping Wang and Zhenzhen Qu
    Citation: BMC Pharmacology and Toxicology 2024 25:1
  24. Previously, observational studies showed that amlodipine can mitigate calcineurin inhibitor- and contrast-induced acute kidney injury (AKI). Herein, we aimed to measure the effect of amlodipine on renal ischem...

    Authors: Hadi Shirzad, Seyed Amin Mousavinezhad, Mohammad Panji and Moin Ala
    Citation: BMC Pharmacology and Toxicology 2023 24:82
  25. Quercetin (QC) possesses a variety of health-promoting effects in pure and in conjugation with nanoparticles. Since the mRNA-SIRT1/p66Shc pathway and microRNAs (miRNAs) are implicated in the oxidative process,...

    Authors: Mahnaz Karami Chamgordani, Akram Bardestani, Shiva Ebrahimpour and Abolghasem Esmaeili
    Citation: BMC Pharmacology and Toxicology 2023 24:81
  26. Feminizing gender-affirming hormone therapy (GAHT) for transgender individuals traditionally includes estradiol and androgen deprivation. Research has demonstrated that breast size as a result of GAHT in trans...

    Authors: Benthe A.M. Dijkman, Danithsia Helder, Lidewij S. Boogers, Noor C. Gieles, Jason O. van Heesewijk, Sjoerd te Slaa, Niels P.T.J. Liberton, Chantal M. Wiepjes, Christel J.M. de Blok, Martin den Heijer and Koen M.A. Dreijerink
    Citation: BMC Pharmacology and Toxicology 2023 24:80
  27. The prevalence of hyperuricemia has increased steadily with the continuous improvement of living standards. Some studies have reported the clinical effectiveness and safety of different doses of febuxostat in ...

    Authors: Hong Xie, Nan Hu, Ting Pan, Jun-Cai Wu, Miao Yu and Deng-Chao Wang
    Citation: BMC Pharmacology and Toxicology 2023 24:79
  28. Microcystins (MCs), potent hepatotoxins pose a significant health risk to humans, particularly children, who are more vulnerable due to higher water intake and increased exposure during recreational activities.

    Authors: Madhura More, Somdatta Chatterjee, Punnag Saha, Dipro Bose, Ayushi Trivedi, Subhajit Roy and Saurabh Chatterjee
    Citation: BMC Pharmacology and Toxicology 2023 24:78
  29. Venous thromboembolic disease (VTE) is characterized by obstruction of venous blood flow by a thrombus. Survival data, frequency of disease recurrence, and bleeding rate in patients on anticoagulant therapy wi...

    Authors: Estefan Ramos-Isaza, Eduardo Tuta-Quintero, Alirio Bastidas-Goyes, Diana Diaz-Quijano, Carolina Aponte-Murcia, Julian Espitia-Angel, Daniel Pinto-Beltran, Johan Rincón-Hernández, Juan Sánchez-Cuellar, Jesus Pérez-Bueno and Luis F. Giraldo-Cadavid
    Citation: BMC Pharmacology and Toxicology 2023 24:77
  30. Cyclophosphamide (CP) is an antineoplastic drug commonly used worldwide. Despite its spread, it causes fatal organ toxicity. Lung toxicity is a serious side effect of CP. Actually, in the past three years the ...

    Authors: Dalia H. El-Kashef and Mona Abdel Rahim
    Citation: BMC Pharmacology and Toxicology 2023 24:76
  31. Metformin is recommended as a first-line drug in the guidelines of the treatment for type 2 diabetes mellitus. However, high-quality evidence from clinical trials directly comparing the degree of hypoglycemic ...

    Authors: Ryosuke Ono, Chika Ogami, Chihiro Hasegawa, Hideto To, Yoshiaki Matsumoto and Yasuhiro Tsuji
    Citation: BMC Pharmacology and Toxicology 2023 24:75
  32. Integrase strand transfer inhibitor (INSTIs)-based combination antiretroviral treatment in people living with HIV (PLWH) has been reportedly correlated with several adverse effects, such as weight gain, fetal ...

    Authors: Shin-Huei Kuo, Wen-Li Hsu, Ching-Ying Wu, Yu-Chang Lai and Tun-Chieh Chen
    Citation: BMC Pharmacology and Toxicology 2023 24:74
  33. Our study aimed to assess the risk signals of antibiotic-associated diarrhea (AAD) caused by various antibiotics using real-world data and provide references for safe clinical applications.

    Authors: Haining Huang, Lanfang Li, Mingli Wu, Zhen Liu, Yanyan Zhao, Jing Peng, Xiaolei Ren and Shuai Chen
    Citation: BMC Pharmacology and Toxicology 2023 24:73
  34. Nebulizers are commonly used to treat respiratory diseases, which are a major cause of morbidity and mortality. While inhalation therapy with antibodies has been evaluated in preclinical studies and clinical t...

    Authors: Soon Woo Hong, Kyung Hwa Chang, Chang Jae Woo, Ho Chul Kim, Bong Seop Kwak, Bong Joo Park and Ki Chang Nam
    Citation: BMC Pharmacology and Toxicology 2023 24:70
  35. The prediction of intestinal absorption of various drugs based on computer simulations has been a reality. However, in vivo pharmacokinetic simulations and virtual bioequivalence evaluation based on GastroPlus...

    Authors: Lu Wang, Jinliang Chen, Wenjun Chen, Zourong Ruan, Honggang Lou, Dandan Yang and Bo Jiang
    Citation: BMC Pharmacology and Toxicology 2023 24:69
  36. Imidacloprid is a neonicotinoid insecticide belonging to the chloronicotinyl nitroguanidine chemical family. Toxicity of IMD for mammals in scientific studies has shown high mutagenic, immunotoxic, teratogenic...

    Authors: Amina Sardar, Mehwish David, Sarwat Jahan, Tayyaba Afsar, Aneela Ahmad, Asad Ullah, Ali Almajwal, Huma Shafique and Suhail Razak
    Citation: BMC Pharmacology and Toxicology 2023 24:68
  37. Atherosclerosis is a form of cardiovascular disease that affects the endothelium of the blood vessel. Series of events are involved in the pathophysiology of this disease which includes the breaking down of th...

    Authors: Temitope Akinwumi Ajani, Kenechukwu Obikeze, Zandisiwe E. Magwebu, Samuel Egieyeh and Chesa G. Chauke
    Citation: BMC Pharmacology and Toxicology 2023 24:67
  38. The study was designed to investigate effects of single intravenous injection of esketamine on the incidence of postpartum depression (PPD) after labor analgesia and explore the potential mechanisms.

    Authors: Bin Ling, Yun Zhu, Zelin Yan, Hao Chen, Hua Xu, Qi Wang, Wanyou Yu and Wei Wang
    Citation: BMC Pharmacology and Toxicology 2023 24:66
  39. Dyslipidemia, characterized by elevated levels of triglycerides (TG), low-density lipoprotein (LDL), total cholesterol (TC), and reduced levels of high-density lipoprotein (HDL), is a major risk factor for car...

    Authors: Mohsen Yousefi, Sahand Tehrani Fateh, Mahlagha Nikbaf-Shandiz, Fatemeh Gholami, Samira Rastgoo, Reza Bagher, Alireza Khadem, Farideh Shiraseb and Omid Asbaghi
    Citation: BMC Pharmacology and Toxicology 2023 24:65
  40. Adverse drug reactions (ADRs) caused by opioid drugs show individual differences. Our objective was to explore the association between gene polymorphism and ADRs induced by opioid drugs.

    Authors: Jing Yang, Ying-zi Sun, Qun-fang Li, Zheng Fu, Yu-yao Guan, Chao Song and Lei Zheng
    Citation: BMC Pharmacology and Toxicology 2023 24:64
  41. Pertuzumab is widely used for the treatment of HER2 + breast cancer. But its safety in the real world should be continuously monitored. So, we evaluated the safety of pertuzumab by pharmacovigilance analyze ba...

    Authors: Shu-peng Zou, Hai-yun Yang, Meng-ling Ouyang, Qian Cheng, Xuan Shi and Ming-hui Sun
    Citation: BMC Pharmacology and Toxicology 2023 24:62
  42. The potentially adverse effects of cannabis (marijuana), a common leisure compound, on male reproductive performance are a reason for concern. δ-9-tetrahydrocannabinol (THC), the primary active component of ma...

    Authors: Shadi Mohammadpour-Asl, Shiva Roshan-Milani, Amin Abdollahzade Fard and Ali Golchin
    Citation: BMC Pharmacology and Toxicology 2023 24:61
  43. Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by the degeneration of nigrostriatal dopaminergic neurons and movement impairment. Based on theories, neuroinflammatory proces...

    Authors: Zahra Salari, Ghorbangol Ashabi, Ali Fartoosi, Ahmad Fartoosi, Marjan Shariatpanahi, Mehdi Aghsami, Hamed Montazeri and Afshin Kheradmand
    Citation: BMC Pharmacology and Toxicology 2023 24:60
  44. Aluminum phosphide toxicity is a serious problem in many countries. Unfortunately, there is no specific antidote. N-acetylcysteine has been used in some studies as adjuvant therapy depending on to its antioxid...

    Authors: Heba Othman Shaker, Omar El Sayed Rageh, Maged Alnajar, Nesreen Fares Alshamaly, Walaa Abdelfattah Abdelmaged and Mohamed Abd-ElGawad
    Citation: BMC Pharmacology and Toxicology 2023 24:59
  45. The illicit use and abuse of gamma-hydroxybutyric acid (GHB) occurs due to its sedative/hypnotic and euphoric effects. Currently, there are no clinically available therapies to treat GHB overdose, and care foc...

    Authors: Hao Wei, Jieyun Cao, Tyler Fallert, Su Yeo and Melanie A. Felmlee
    Citation: BMC Pharmacology and Toxicology 2023 24:58
  46. Authors: Jui-Ting Chang, Yao-Jen Liang, Chia-Yu Hsu, Chao-Yi Chen, Po-Jung Chen, Yi-Feng Yang, Yen-Lin Chen, Dee Pei, Jin-Biou Chang and Jyh-Gang Leu
    Citation: BMC Pharmacology and Toxicology 2023 24:57

    The original article was published in BMC Pharmacology and Toxicology 2017 18:67

  47. Complications and fata toxicity induced by chemotherapy are the main challenge for clinical management of osteosarcoma. The identification of agents that can augment the efficacy of chemotherapy at lower doses...

    Authors: Zhaoming Han, Juguang Yang, Ping Wang, Feng Bian and Jiguang Jia
    Citation: BMC Pharmacology and Toxicology 2023 24:56
Reviewer acknowledgments

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