Figure 1From: Coumestrol from the national cancer Institute’s natural product library is a novel inhibitor of protein kinase CK2 Inhibition effects of representative natural compounds on CK2 kinase activity. A. Natural compounds from NCI plates were screened for their CK2 inhibition activities at 10 μM using a kinase assay. Relative kinase activity of CK2 is shown on the Y axis as a relative number to the control that did not have inhibitor treatment. Compounds 1-F4 (coumestrol), 1-D6 (curcumin) and 1-F3 (aristolochic acid I) showed more than 50% inhibition on kinase activity at 10 μM. Data represents the average of duplicates and bars indicate standard deviation. 1-X represents compounds from NCI plate 13091250 and 2-X represents compounds from NCI plate 13091251. B. Chemical structures of coumestrol, curcumin and aristolochic acid I. C. IC50 of coumestrol.Back to article page