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Open Access

Lessons from tissue-specific KO of CNP/GC-B system - everlasting challenge to clinical application

  • Kazuwa Nakao1Email author,
  • Koitiro Kuwahara1,
  • Hiroaki Yasoda1,
  • Goro Katuura1,
  • Kazuhiro Nakao1,
  • Kazumasa Nakao1 and
  • Yui Yamasita1
BMC Pharmacology and Toxicology201314(Suppl 1):O4

Published: 29 August 2013


PeptideClinical ApplicationCardiovascular SystemKnockout MouseNatriuretic Peptide

Since the identification of the first natriuretic peptide, ANP, from the atrium of the heart, thirty years have passed and clinical applications have been achieved in ANPBNP/GC-A system. In contrast with the distribution of the ANPBNP/GC-A system as the endocrine system, the CNP/GC-B system is distributed as the paracrine/autocrine system.

In order to assess physiological rolls of the CNP/GC-B system, we have developed tissue –specific knockout mice using the Cre-Lox-P system. Here, we present results of both CNP knockout mice and GC-B knockout mice in the brain, bone and cardiovascular system and discuss the possible physiological and pathophysiological implications of the CNP/GC-B system.

Authors’ Affiliations

Medical Innovation Center and Dept. of Med. and Clin. Sci., Kyoto Univ. Graduate School of Med., Kyoto, Japan


© Nakao et al; licensee BioMed Central Ltd. 2013

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.