Lessons from tissue-specific KO of CNP/GC-B system - everlasting challenge to clinical application
BMC Pharmacology and Toxicology volume 14, Article number: O4 (2013)
Since the identification of the first natriuretic peptide, ANP, from the atrium of the heart, thirty years have passed and clinical applications have been achieved in ANP⋅BNP/GC-A system. In contrast with the distribution of the ANP⋅BNP/GC-A system as the endocrine system, the CNP/GC-B system is distributed as the paracrine/autocrine system.
In order to assess physiological rolls of the CNP/GC-B system, we have developed tissue –specific knockout mice using the Cre-Lox-P system. Here, we present results of both CNP knockout mice and GC-B knockout mice in the brain, bone and cardiovascular system and discuss the possible physiological and pathophysiological implications of the CNP/GC-B system.
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Nakao, K., Kuwahara, K., Yasoda, H. et al. Lessons from tissue-specific KO of CNP/GC-B system - everlasting challenge to clinical application. BMC Pharmacol Toxicol 14 (Suppl 1), O4 (2013). https://doi.org/10.1186/2050-6511-14-S1-O4
- Clinical Application
- Cardiovascular System
- Knockout Mouse
- Natriuretic Peptide