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Lessons from tissue-specific KO of CNP/GC-B system - everlasting challenge to clinical application

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Since the identification of the first natriuretic peptide, ANP, from the atrium of the heart, thirty years have passed and clinical applications have been achieved in ANPBNP/GC-A system. In contrast with the distribution of the ANPBNP/GC-A system as the endocrine system, the CNP/GC-B system is distributed as the paracrine/autocrine system.

In order to assess physiological rolls of the CNP/GC-B system, we have developed tissue –specific knockout mice using the Cre-Lox-P system. Here, we present results of both CNP knockout mice and GC-B knockout mice in the brain, bone and cardiovascular system and discuss the possible physiological and pathophysiological implications of the CNP/GC-B system.

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Correspondence to Kazuwa Nakao.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Nakao, K., Kuwahara, K., Yasoda, H. et al. Lessons from tissue-specific KO of CNP/GC-B system - everlasting challenge to clinical application. BMC Pharmacol Toxicol 14, O4 (2013). https://doi.org/10.1186/2050-6511-14-S1-O4

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Keywords

  • Peptide
  • Clinical Application
  • Cardiovascular System
  • Knockout Mouse
  • Natriuretic Peptide