Volume 14 Supplement 1

6th International Conference on cGMP: Generators, Effectors and Therapeutic Implications

Meeting abstracts

Edited by John C Burnett Jr, Franz Hofmann, Kazuwa Nakao, Harald HHW Schmidt and Johannes-Peter Stasch

Publication of this supplement has been fully funded by Bayer Pharma AG. Johannes-Peter Stasch is an employee of Bayer Pharma AG, Wuppertal, Germany. He holds many patents on sGC stimulators and sGC activators. John C Burnett Jr is the chairman of the advisory board for Nile Therapeutics and is a Co-Founder and the Chief Scientific Officer for Zumbro Discovery. Mayo Clinic has licensed CD-NP to Nile Therapeutics and MANP to Zumbro Discovery. The other Supplement Editors declare that they have no competing interests.

6th International Conference on cGMP: Generators, Effectors and Therapeutic Implications. Go to conference site.

Erfurt, Germany28-30 June 2013

Page 1 of 3

Chronic natriuretic peptide protein therapeutics

Authors: Horng H Chen, Alessandro Cataliotti and John C Burnett Jr

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O1

Content type: Oral presentation Published on: 29 August 2013
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Increased nitrosative/oxidative stress lowers myocardial protein kinase G activity in heart failure with preserved ejection fraction

Authors: Loek van Heerebeek, Nazha Hamdani, Inês Falcão-Pires, Adelino F Leite-Moreira, Mark PV Begieneman, Jean GF Bronzwaer, Jolanda van der Velden, Ger JM Stienen, Gerrit J Laarman, Aernout Somsen, Freek WA Verheugt, Hans WM Niessen and Walter J Paulus

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O2

Content type: Oral presentation Published on: 29 August 2013
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Abstract not submitted for publication

Authors:

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O3

Content type: Oral presentation Published on: 29 August 2013
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Lessons from tissue-specific KO of CNP/GC-B system - everlasting challenge to clinical application

Authors: Kazuwa Nakao, Koitiro Kuwahara, Hiroaki Yasoda, Goro Katuura, Kazuhiro Nakao, Kazumasa Nakao and Yui Yamasita

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O4

Content type: Oral presentation Published on: 29 August 2013
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What have genome-wide association studies taught us about cGMP and blood pressure regulation?

Authors: Christopher Newton-Cheh

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O5

Content type: Oral presentation Published on: 29 August 2013
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Genetic variants in guanylyl cyclase and phoshodiesterase affecting coronary disease risk

Authors: Heribert Schunkert

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O6

Content type: Oral presentation Published on: 29 August 2013
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Genetic variants of ANP and cardiometabolic protection: from populations to novel therapeutics

Authors: Valentina Cannone, Paul M McKie, Angelo Baldassare Cefalu, Davide Noto, Giovanni Cavera, Michele Pagano, Michelangelo Sapienza, Timothy M Olson, Denise M Heublein, Christopher G Scott, Kent R Bailey, Maurizio Averna and John C Burnett Jr

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O7

Content type: Oral presentation Published on: 29 August 2013
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Genetic modifiers of hypertension in sGC-deficient mice

Authors: Emmanuel Buys

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O8

Content type: Oral presentation Published on: 29 August 2013
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Pulmonary vascular adaptation to high-altitude living

Authors: Martin Wilkins

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O9

Content type: Oral presentation Published on: 29 August 2013
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MicroRNA miR-425 is a negative regulator of atrial natriuretic peptide

Authors: Pankaj Arora, Connie Wu, Donald B Bloch, Brandi N Davis-Dusenbury, Ester Spagnolli, Akiko Hata, Sara Vandenwijngaert, Melissa Swinnen, Stefan Janssens, Emmanuel S Buys, Kenneth D Bloch, Christopher Newton-Cheh and Thomas J Wang

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O10

Content type: Oral presentation Published on: 29 August 2013
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cGMP kinase: past, presence and future

Authors: Franz Hofmann, Florian Loga, Katrin Domes, Enrico Patrucco and Jörg W Wegener

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O11

Content type: Oral presentation Published on: 29 August 2013
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Conformational changes involved in sGC activation

Authors: Michael A Marletta, Eric Underbakke, Melody G Campbell, Bridget Carragher and Clinton S Potter

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O12

Content type: Oral presentation Published on: 29 August 2013
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A twenty year journey to understand how ATP activates guanylyl cyclase A and B

Authors: Lincoln R Potter

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O13

Content type: Oral presentation Published on: 29 August 2013
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Soluble guanylate cyclase crystal clear: 1^stcrystal structure of the wild-type human heterodimeric sGC catalytic domains and implications for activity

Authors: Franziska Seeger and Elsa D Garcin

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O14

Content type: Oral presentation Published on: 29 August 2013
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Crystal structures of human soluble guanylate cyclase catalytic domains: promiscuity of the dimer interface and a potential allosteric site

Authors: Opher Gileadi, Charles Allerston and Frank von Delft

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O15

Content type: Oral presentation Published on: 29 August 2013
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Structures of human PKG reveal cGMP-selectived activation mechanisms

Authors: Gilbert Y Huang, Jeong J Kim, Albert S Reger, Robin Lorenz, Eui-Whan Moon, Chi Zhao, Darren E Casteel, Daniela Bertinetti, Bryan VanSchouwen, Rajeevan Selvaratnam, James W Pflugrath, Banumathi Sankaran, Giuseppe Melacini, Friedrich W Herberg and Choel Kim

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O16

Content type: Oral presentation Published on: 29 August 2013
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Targeting native and apo-sGC

Authors: Mary Struthers, Subharekha Raghavan, Ronald Kim, Christopher Sinz, Sophie Roy and Michael Mendelsohn

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O17

Content type: Oral presentation Published on: 29 August 2013
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Mechanisms driving heme insertion into apo-sGC during its maturation in cells

Authors: Dennis Stuehr, Arnab Ghosh, Anindya Sarkar and Yue Dai

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O18

Content type: Oral presentation Published on: 29 August 2013
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Redox signalling by protein kinase G Iα in cardiovascular physiology and pathology

Authors: Philip Eaton

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O19

Content type: Oral presentation Published on: 29 August 2013
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New mechanisms of normoxic and hypoxic cGMP signalling mediated by the nitrite anion

Authors: Hunter Champion

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O20

Content type: Oral presentation Published on: 29 August 2013
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Thiol-redox proteins interact with soluble guanylyl cyclase and modulate its activity

Authors: Erin J Heckler, Mohit Jain, Pierre-Antoine Crassous, Angelo R Rossi, Hong Li and Annie Beuve

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O21

Content type: Oral presentation Published on: 29 August 2013
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Chronic beta-adrenergic blockade prevents volume overload-induced re-localization and oxidation of soluble guanylyl cyclase

Authors: Yuchuan Liu, Louis Dell’Italia, Victor Rizzo and Emily J Tsai

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O22

Content type: Oral presentation Published on: 29 August 2013
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Elementary Ca²⁺signals through endothelial TRPV4 channels regulate vascular function

Authors: Mark T Nelson, Adrian D Bonev, Thomas Dalsgaard, Luis F Santana, John Scott, Michael I Kotlikoff and Swapnil K Sonkusare

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O23

Content type: Oral presentation Published on: 29 August 2013
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Natriuretic peptides and fat metabolism

Authors: Sheila Collins

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O24

Content type: Oral presentation Published on: 29 August 2013
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Role of cGMP in fat and metabolism

Authors: Alexander Pfeifer, Ana Kilić and Linda Hoffmann

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O25

Content type: Oral presentation Published on: 29 August 2013
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Non-genomic thyroid hormone signaling through NO/cGMP/PKGII

Authors: Hema Kalyanaraman, Raphaela Schwappacher, Jisha Joshua, Shunhui Zhuang, Brian Scott, Wolfgang Dillmann, John Frangos and Renate B Pilz

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O26

Content type: Oral presentation Published on: 29 August 2013
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cGMP-Prkg1 signaling PDE5 inhibition shelter cochlear hair cells and hearing function

Authors: Marlies Knipper, Mirko Jaumann, Francois Paquet-Durand, Peter Ruth, Peter Sandner, Robert Feil, Jutta Engel and Lukas Rüttiger

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O27

Content type: Oral presentation Published on: 29 August 2013
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GUCY2C at the intersection of obesity and colorectal cancer

Authors: Scott A Waldman, Jieru E Lin, Francheska Colon-Gonzalez, Adam Snook, Michael Valentino, Gilbert Kim, Erik Blomain and Theresa Hyslop

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O28

Content type: Oral presentation Published on: 29 August 2013
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Cell type-specific knock out models to unravel NO/cGMP signaling in smooth muscle

Authors: Noomen Bettaga, Dieter Groneberg, Ronald Jäger, Barbara Lies and Andreas Friebe

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O29

Content type: Oral presentation Published on: 29 August 2013
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Interstitial cells of Cajal link excitatory and nitrergic inhibitory neurotransmission with slow-wave activity in the intestine

Authors: Sabine Klein, Barbara Seidler, Anna Kettenberger, Andrei Sibaev, Michael Rohn, Robert Feil, Hans-Dieter Allescher, Jean-Marie Vanderwinden, Franz Hofmann, Michael Schemann, Roland Rad, Martin A Storr, Roland M Schmid, Günter Schneider and Dieter Saur

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O30

Content type: Oral presentation Published on: 29 August 2013
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cGMP-dependent kinase 2, Na⁺/H⁺ regulatory factor 2, and Na⁺/H⁺ exchanger isoform 3 assemble within lipid rafts in murine small intestinal brush border membrane

Authors: Min Luo, Ayesha Sultan, Qin Yu, Brigitte Riederer, Weiliang Xia, Min Luo, Mingmin Chen, Simone Lissner, Engelbert Gessner, Enrico Patrucco, Franz Hofmann, Mark Donowitz, Chris C Yun, Hugo de Jonge, Georg Lamprecht and Ursula Seidler

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O31

Content type: Oral presentation Published on: 29 August 2013
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NO-H₂S interactions involve cGMP

Authors: Andreas Papapetropoulos

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O32

Content type: Oral presentation Published on: 29 August 2013
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67-kDa laminin receptor and cGMP induced cancer-selective apoptosis

Authors: Motofumi Kumazoe and Hirofumi Tachibana

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O33

Content type: Oral presentation Published on: 29 August 2013
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A novel physiological significance of natriuretic peptides in cancer metastasis

Authors: Kenji Kangawa, Takashi Nojiri, Hiroshi Hosoda, Takeshi Tokudome and Meinoshin Okumura

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O34

Content type: Oral presentation Published on: 29 August 2013
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Dual actions of ANP on endothelial permeability

Authors: Wen Chen, Heike Oberwinkler, Franziska Werner, Birgit Gaßner, Hitoshi Nakagawa, Robert Feil, Franz Hofmann, Jens Schlossmann, Alexander Dietrich, Thomas Gudermann, Motohiro Nishida, Sabrina Del Galdo, Thomas Wieland and Michaela Kuhn

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O35

Content type: Oral presentation Published on: 29 August 2013
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Pseudomonas aeruginosaExoY, a cyclic GMP- and cyclic UMP-generating nucleotidyl cyclase

Authors: Roland Seifert, Christina Hartwig, Sabine Wolter, Daniel Reinecke, Heike Burhenne, Volkhard Kaever, Antje Munder, Burkhard Tümmler, Frank Schwede, Manuel Grundmann, Evi Kostenis, Dara W Frank and Ulrike Beckert

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O36

Content type: Oral presentation Published on: 29 August 2013
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Nitric oxide regulated cyclic di-GMP signaling

Authors: Elizabeth M Boon, Zhou Dai, Niu Liu, Bernadette Henares, Dhruv Arora and Tanaya Lahiri

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O37

Content type: Oral presentation Published on: 29 August 2013
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Differential effects of PDE5 inhibitors on cardiac dysfunction in the MDX ouse model of Duchenne muscular dystrophy

Authors: Sergei D Rybalkin, Masami Shimizu, Irina G Rybalkina, Enrico Patrucco, Kenneth Bible, Elina Minami, Jennifer O'Brien, Lawrence P Wennogle, Franz Hofmann, Joseph A Beavo and Stanley C Froehner

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O38

Content type: Oral presentation Published on: 29 August 2013
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Neutral endopeptidase inhibitors SOL-1 and candoxatril counteract kidney fibrosis by reducing myofibroblast formation in mouse UUO model

Authors: Marina Aleksinskaya, Jacques Duijs, Jennifer Veth, Bettina Husen, Dania Reiche, Daniel Jasserand, Jo De Mey, Ton Rabelink and Anton Jan van Zonneveld

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P1

Content type: Poster presentation Published on: 29 August 2013
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Hydroxyurea reduces leukocyte interactions with the vessel wall in a haemolytic mouse model via a possible NO/cGMP-mediated effect

Authors: Camila B Almeida, Claudio C Werneck, Cristina C Vicente, Fábio T Costa, Fernando F Costa and Nicola Conran

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P2

Content type: Poster presentation Published on: 29 August 2013
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Effect of nitrite treatment on endothelial nitric oxide synthase in human left ventricle biopsy

Authors: Jenna Bailey, Sayqa Arif, Jorge Mascaro, Robert S Bonser, Michael P Frenneaux and Melanie Madhani

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P3

Content type: Poster presentation Published on: 29 August 2013
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A possible crosstalk between cGMP pathway and Activin receptor-like kinase 7 (Alk7) in adipocytes

Authors: Aileen Balkow, Johanna Jagow, Ana Kilic and Alexander Pfeifer

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P4

Content type: Poster presentation Published on: 29 August 2013
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Pharmacokinetic interaction of ketoconazole, clarithromycin, and midazolam with riociguat

Authors: Corina Becker, Reiner Frey, Sigrun Unger, Dirk Thomas, Michael Reber, Gerrit Weimann, Hartmut Dietrich, Erich R Arens and Wolfgang Mueck

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P5

Content type: Poster presentation Published on: 29 August 2013
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Effects of omeprazole and AlOH/MgOH on riociguat absorption

Authors: Corina Becker, Reiner Frey, Sigrun Unger, Ulrike Artmeier-Brandt, Gerrit Weimann and Wolfgang Mueck

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P6

Content type: Poster presentation Published on: 29 August 2013
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Absorption behavior of riociguat: bioavailability, food effects, and dose-proportionality

Authors: Corina Becker, Reiner Frey, Christiane Hesse, Sigrun Unger, Michael Reber and Wolfgang Mueck

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P7

Content type: Poster presentation Published on: 29 August 2013
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Role of NO-sensitive guanylyl cyclase in angiogenesis and arteriogenesis

Authors: Noomen Bettaga, Andreas Friebe and Ronald Jäger

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P8

Content type: Poster presentation Published on: 29 August 2013
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NO-cGMP signalling and cancer therapy

Authors: Ka Bian, Alex Sotolongo, Huy Lam, Haijie Xiao, Dandan Zhang, Jun Liu and Ferid Murad

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P9

Content type: Poster presentation Published on: 29 August 2013
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Identification of protein kinase G I alpha interacting proteins as potential targets to prevent cardiac remodeling

Authors: Robert Blanton, Angela Lane, Mark Aronovitz, Guang-Rong Wang, Robrecht Thoonen, Roger Davis, Michael Mendelsohn, David Kass and Richard Karas

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P10

Content type: Poster presentation Published on: 29 August 2013
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G-protein signaling modulator 1 is a modifier of sGC-dependent vascular response

Authors: George Britton, Iraida Sharina and Emil Martin

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P11

Content type: Poster presentation Published on: 29 August 2013
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Identification and quantitation of 2´,3´-cGMP in murine tissues

Authors: Heike Burhenne, Sarah Tschirner, Roland Seifert and Volkhard Kaever

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P12

Content type: Poster presentation Published on: 29 August 2013
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6th International Conference on cGMP: Generators, Effectors and Therapeutic Implications

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