Background
cGMP is synthesized via nitric oxide- or natriuretic peptide-stimulated guanylyl cyclases and exhibits pleiotropic regulatory functions also in the kidney. Both isoforms of cGKI (α, β) have been detected in arterioles, mesangium and within the cortical interstitium. In contrast to cGKIα, the β-isoform was not detected in the juxtaglomerular apparatus and in medullary fibroblasts.
The aim of this study was to examine the function of cGKI in the renal interstitium, emphasizing a functional differentiation of both isoforms. Interstitium fibroblasts play a prominent role in interstitial fibrosis. Accordingly, cGKI may also be involved in this pathophysiological process.