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Figure 6 | BMC Pharmacology and Toxicology

Figure 6

From: Effects of cytarabine on activation of human T cells – cytarabine has concentration-dependent effects that are modulated both by valproic acid and all-trans retinoic acid

Figure 6

The release of FasL, TRAIL, HSP70 and HSP90 by anti-CD3 plus anti-CD28 activated normal T cells – effects of cytarabine, ATRA and valproic acid tested alone or in combination. The supernatant concentrations of FasL, TRAIL, HSP90 and HSP70 were determined after 4 days of PBMC culture with anti-CD3 plus anti-CD28. Cultures were prepared in medium alone or together with the single drugs or drug combinations indicated in the figures. (A) The upper figure presents the FasL (left panel) and TRAIL (right panel) levels, the lower figure (B) presents the levels of HSP90 (left panel) and HSP70 (right panel). All results are presented as the mean with SD. Repeated measures ANOVA with Dunnett’s Multiple Comparison Test against control samples were used for statistical analyses (*p <0.05; **p <0.01; ***p <0.001).

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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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