Fig. 2

PK fold change (Cmax) vs. PD fold change (QTc). Fold change = C_maxCombination/C_maxDrug and ΔQTcCombination/ΔQTcDrug; Negative values of QTc fold change represent QTc interval change for negative ΔQTc values as compared to baseline (QTc shortening for single drug, as well as for the combination)