Table 1 Activity of N-(2-mercaptopropionyl) glycine (MPG), vitamin C (Vit-C), grape seed proanthocyanidin (GP), B. monnieri n-butanolic fraction (BM-ButFr) and their combination against cisplatin induced vomiting during a 24 h observation period

Cisplatin

7.0 mg/kg i.v.

8/8

50 ± 3.2

70.0 ± 2.30

561 ± 56.4

16 ± 1.8

Metoclopramide

30 mg/kg i.m.

8/8

8 ± 0.8^***

417 ± 7.00^***

134 ± 12.5^***

4 ± 0.6^***

MPG

10 mg/kg i.m.

8/6

12 ± 5.8^***

410 ± 162^*

135 + 55.6^***

4 ± 1.9^**

20 mg/kg i.m.

8/7

21 ± 4.9^**

91.0 ± 11.5

226 + 80.9^*

7 ± 1.2^*

30 mg/kg i.m.

8/7

23 ± 5.6^**

89.0 ± 21.1

329 + 79.2

7 ± 3.2^*

Vit-C

100 mg/kg i.m.

8/8

30 ± 3.2^**

146 ± 16.7

384 ± 23.5^*

7 ± 1.3^***

200 mg/kg i.m.

8/8

24 ± 4.6^***

316 ± 96.2^*

332 ± 52.4^**

5 ± 1.1^***

300 mg/kg i.m.

8/8

24 ± 3.0^***

359 ± 73.2^*

256 ± 21.0^***

3 ± 0.5^***

GP

50 mg/kg i.m.

8/8

14 ± 3.5^***

348 ± 42.5^***

236 ± 78.9^**

6 ± 0.8^***

100 mg/kg i.m.

8/8

12 ± 2.2^***

370 ± 31.6^***

184 ± 37.0^***

6 ± 1.0^***

150 mg/kg i.m.

8/8

9.0 ± 0.9^***

369 ± 27.8^***

139 ± 27.2^***

5 ± 0.5^***

BM-ButFr

5 mg/kg i.m.

8/8

17 ± 2.6^***

161 ± 25.0

331 ± 74.0

7 ± 0.5^**

10 mg/kg i.m.

8/8

15 ± 2.1^***

145 ± 36.0

378 ± 58.0

6 ± 1.4^***

20 mg/kg i.m.

8/8

13 ± 1.7^***

137 ± 25.0

253 ± 45.0^**

5 ± 1.7^***

 MPG + Vit-C

10 mg/kg + 200 mg/kg i.m.

7/7

12 ± 4.7^***

421 ± 134^*

201 ± 68.2^***

3 ± 1.1^***

 BM-ButFr + GP

10 mg/kg + 100 mg i.m.

8/8

17 ± 0.9^***

195 ± 24.1

196 ± 16.3^***

5 ± 0.2^***

 GP + Vit-C

100 mg/kg + 200 mg/kg i.m.

8/8

9.0 ± 3.3^***

309 ± 90.6

166 ± 61.3^***

3 ± 0.9^***