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Table 2 Effect of Co-Q10 on biochemical parameters in ISO induced aged rats

From: Coenzyme Q10 prevents oxidative stress and fibrosis in isoprenaline induced cardiac remodeling in aged rats

Parameters Group
Control ISO ISO + CoQ10
Plasma
 AST (U/L) 29.29 ± 4.39a 51.68 ± 4.72b 33.02 ± 3.46a
 ALT (U/L) 33.02 ± 4.67a 78.96 ± 18.79b 44.50 ± 6.06a
 ALP (U/L) 57.60 ± 4.88a 82.15 ± 5.85b 60.67 ± 3.11a
 MDA (nmol/mL) 78.51 ± 6.12a 174.54 ± 6.11b 101.72 ± 10.89a
 NO (nmol/mL) 3.82 ± 0.25a 11.12 ± 1.69b 6.82 ± 0.55a
 APOP (nmol/mL equivalent to Chloramine-T) 229.13 ± 10.64a 382.30 ± 31.75b 200.16 ± 19.43a
 Catalase (U/min) 22.50 ± 4.23a 10.00 ± 1.83b 15.00 ± 2.58a
 GSH (ng/mg protein) 11.59 ± 0.46 ns 7.16 ± 0.53 ns 13.65 ± 0.53 ns
 CK-MB (U/L) 136.11 ± 19.44a 299.44 ± 31.55b 151.67 ± 34.48a
 Uric Acid (μmol/L) 5.02 ± 0.52a 10.65 ± 0.75b 7.82 ± 0.56b
 Creatinin (μmol/L) 1.36 ± 0.10a 2.34 ± 0.19b 1.52 ± 0.03b
Heart
 MDA (nmol/gm tissue) 52.62 ± 3.96a 102.62 ± 4.40b 80.56 ± 6.10a
 NO (nmol/gm tissue) 13.26 ± 0.64 ns 15.49 ± 1.06 ns 8.38 ± 0.28 ns
 APOP (nmol/gm tissue equivalent to Chloramine-T) 624.13 ± 29.80a 924.92 ± 107.66b 569.37 ± 38.78a
 Catalase (U/min) 145.83 ± 18.68a 83.33 ± 8.82b 94.17 ± 6.38a
 GSH (ng/mg protein) 12.47 ± 0.44 ns 9.38 ± 0.81 ns 16.77 ± 1.04 ns
Kidney
 MDA (nmol/gm tissue) 40.31 ± 0.79a 85.82 ± 2.55b 66.85 ± 2.01b
 NO (nmol/gm tissue) 21.54 ± 1.43a 33.82 ± 2.38b 18.77 ± 2.30a
 APOP (nmol/gm tissue equivalent to Chloramine-T) 711.43 ± 20.75a 1143.97 ± 96.08b 911.43 ± 68.81b
 Catalase (U/min) 36.67 ± 5.11a 16.67 ± 2.47b 29.17 ± 2.71a
 GSH (ng/mg protein) 17.94 ± 0.42 ns 12.84 ± 0.57 ns 15.05 ± 2.42 ns
Urine
  Control ISO ISO + COQ10
Uric Acid (μmol/L) 6.02 ± 0.06a 9.42 ± 0.26b 7.13 ± 0.25a
Creatinin (μmol/L) 8.16 ± 0.75a 17.75 ± 2.32b 7.03 ± 1.18a
  1. Data are presented as mean ± SEM, n = 6. Statistical analysis was done as One way ANOVA with Newman Keuls test as post hoc test, which was conducted using Prism software (USA).). a vs b is significantly different at p < 0.05. a vs b, control vs ISO or ISO vs ISO + CoQ10. Others are not significant