Table 2 Effect of Co-Q10 on biochemical parameters in ISO induced aged rats
Parameters | Group | ||
|---|---|---|---|
Control | ISO | ISO + CoQ10 | |
Plasma | |||
 AST (U/L) | 29.29 ± 4.39a | 51.68 ± 4.72b | 33.02 ± 3.46a |
 ALT (U/L) | 33.02 ± 4.67a | 78.96 ± 18.79b | 44.50 ± 6.06a |
 ALP (U/L) | 57.60 ± 4.88a | 82.15 ± 5.85b | 60.67 ± 3.11a |
 MDA (nmol/mL) | 78.51 ± 6.12a | 174.54 ± 6.11b | 101.72 ± 10.89a |
 NO (nmol/mL) | 3.82 ± 0.25a | 11.12 ± 1.69b | 6.82 ± 0.55a |
 APOP (nmol/mL equivalent to Chloramine-T) | 229.13 ± 10.64a | 382.30 ± 31.75b | 200.16 ± 19.43a |
 Catalase (U/min) | 22.50 ± 4.23a | 10.00 ± 1.83b | 15.00 ± 2.58a |
 GSH (ng/mg protein) | 11.59 ± 0.46 ns | 7.16 ± 0.53 ns | 13.65 ± 0.53 ns |
 CK-MB (U/L) | 136.11 ± 19.44a | 299.44 ± 31.55b | 151.67 ± 34.48a |
 Uric Acid (μmol/L) | 5.02 ± 0.52a | 10.65 ± 0.75b | 7.82 ± 0.56b |
 Creatinin (μmol/L) | 1.36 ± 0.10a | 2.34 ± 0.19b | 1.52 ± 0.03b |
Heart | |||
 MDA (nmol/gm tissue) | 52.62 ± 3.96a | 102.62 ± 4.40b | 80.56 ± 6.10a |
 NO (nmol/gm tissue) | 13.26 ± 0.64 ns | 15.49 ± 1.06 ns | 8.38 ± 0.28 ns |
 APOP (nmol/gm tissue equivalent to Chloramine-T) | 624.13 ± 29.80a | 924.92 ± 107.66b | 569.37 ± 38.78a |
 Catalase (U/min) | 145.83 ± 18.68a | 83.33 ± 8.82b | 94.17 ± 6.38a |
 GSH (ng/mg protein) | 12.47 ± 0.44 ns | 9.38 ± 0.81 ns | 16.77 ± 1.04 ns |
Kidney | |||
 MDA (nmol/gm tissue) | 40.31 ± 0.79a | 85.82 ± 2.55b | 66.85 ± 2.01b |
 NO (nmol/gm tissue) | 21.54 ± 1.43a | 33.82 ± 2.38b | 18.77 ± 2.30a |
 APOP (nmol/gm tissue equivalent to Chloramine-T) | 711.43 ± 20.75a | 1143.97 ± 96.08b | 911.43 ± 68.81b |
 Catalase (U/min) | 36.67 ± 5.11a | 16.67 ± 2.47b | 29.17 ± 2.71a |
 GSH (ng/mg protein) | 17.94 ± 0.42 ns | 12.84 ± 0.57 ns | 15.05 ± 2.42 ns |
Urine | |||
|  | Control | ISO | ISO + COQ10 |
Uric Acid (μmol/L) | 6.02 ± 0.06a | 9.42 ± 0.26b | 7.13 ± 0.25a |
Creatinin (μmol/L) | 8.16 ± 0.75a | 17.75 ± 2.32b | 7.03 ± 1.18a |