Tsochatzis EA, Bosch J, Burroughs AK. Liver cirrhosis. Lancet. 2014;383:1749–61.
Article
Google Scholar
Arzumanyan A, Reis HM, Feitelson MA. Pathogenic mechanisms in HBV- and HCV-associated hepatocellular carcinoma. Nat Rev Cancer. 2013;13:123–35.
Article
CAS
Google Scholar
Moradpour D, Blum HE. Pathogenesis of hepatocellular carcinoma. Eur J Gastroenterol Hepatol. 2005;17:477–83.
Article
Google Scholar
Shokoohinia Y, Rashidi M, Hosseinzadeh L, Jelodarian Z. Quercetin-3-O-beta-D-glucopyranoside, a dietary flavonoid, protects PC12 cells from H(2)O(2)-induced cytotoxicity through inhibition of reactive oxygen species. Food Chem. 2015;167:162–7.
Article
CAS
Google Scholar
Sonoki H, Sato T, Endo S, Matsunaga T, Yamaguchi M, Yamazaki Y, Sugatani J, Ikari A. Quercetin decreases Claudin-2 expression mediated by up-regulation of microRNA miR-16 in lung adenocarcinoma A549 cells. Nutrients. 2015;7:4578–92.
Article
CAS
Google Scholar
Pinelo M, Manzocco L, Nunez MJ, Nicoli MC. Interaction among phenols in food fortification: negative synergism on antioxidant capacity. J Agric Food Chem. 2004;52:1177–80.
Article
CAS
Google Scholar
Hatahet T, Morille M, Shamseddin A, Aubert-Pouessel A, Devoisselle JM, Begu S. Dermal quercetin lipid nanocapsules: influence of the formulation on antioxidant activity and cellular protection against hydrogen peroxide. Int J Pharm. 2017;518:167–76.
Article
CAS
Google Scholar
Kemelo MK, Pierzynova A, Kutinova Canova N, Kucera T, Farghali H. The involvement of sirtuin 1 and heme oxygenase 1 in the hepatoprotective effects of quercetin against carbon tetrachloride-induced sub-chronic liver toxicity in rats. Chem Biol Interact. 2017;269:1–8.
Article
CAS
Google Scholar
Ghosh A, Mandal AK, Sarkar S, Das N. Hepatoprotective and neuroprotective activity of liposomal quercetin in combating chronic arsenic induced oxidative damage in liver and brain of rats. Drug Deliv. 2011;18:451–9.
Article
CAS
Google Scholar
Ji LL, Sheng YC, Zheng ZY, Shi L, Wang ZT. The involvement of p62-Keap1-Nrf2 antioxidative signaling pathway and JNK in the protection of natural flavonoid quercetin against hepatotoxicity. Free Radic Biol Med. 2015;85:12–23.
Article
CAS
Google Scholar
Afifi NA, Ibrahim MA, Galal MK. Hepatoprotective influence of quercetin and ellagic acid on thioacetamide-induced hepatotoxicity in rats. Can J Physiol Pharmacol. 2018;96:624–9.
Article
CAS
Google Scholar
Zhuo H, Zheng B, Liu J, Huang Y, Wang H, Zheng D, Mao N, Meng J, Zhou S, Zhong L, Zhao Y. Efficient targeted tumor imaging and secreted endostatin gene delivery by anti-CD105 immunoliposomes. J Exp Clin Cancer Res. 2018;37:42.
Article
Google Scholar
Wang G, Wang JJ, Yang GY, Du SM, Zeng N, Li DS, Li RM, Chen JY, Feng JB, Yuan SH, Ye F. Effects of quercetin nanoliposomes on C6 glioma cells through induction of type III programmed cell death. Int J Nanomedicine. 2012;7:271–80.
Article
CAS
Google Scholar
Mukhopadhyay P, Maity S, Mandal S, Chakraborti AS, Prajapati AK, Kundu PP. Preparation, characterization and in vivo evaluation of pH sensitive, safe quercetin-succinylated chitosan-alginate core-shell-corona nanoparticle for diabetes treatment. Carbohydr Polym. 2018;182:42–51.
Article
CAS
Google Scholar
Zhang YD, Wang JW, Liu XY, Zhao ZY, Zhang LH, Long B. Study on distribution of liposome nanoparticles loaded quercetin in rats. Chin Med Eng. 2007;15:305–8.
CAS
Google Scholar
Zhang HY, Han DW, Zhao ZF, Liu MS, Wu YJ, Chen XM, Ji C. Multiple pathogenic factor-induced complications of cirrhosis in rats: a new model of hepatopulmonary syndrome with intestinal endotoxemia. World J Gastroenterol. 2007;13:3500–7.
Article
CAS
Google Scholar
Billerbeck E, Wolfisberg R, Fahnoe U, Xiao JW, Quirk C, Luna JM, Cullen JM, Hartlage AS, Chiriboga L, Ghoshal K, Lipkin WI, Bukh J, Scheel TKH, Kapoor A, Rice CM. Mouse models of acute and chronic hepacivirus infection. Science. 2017;357:204–8.
Article
CAS
Google Scholar
Cubero FJ, Zoubek ME, Hu W, Peng J, Zhao G, Nevzorova YA, Al Masaoudi M, Bechmann LP, Boekschoten MV, Muller M, Preisinger C, Gassler N, Canbay AE, Luedde T, Davis RJ, Liedtke C, Trautwein C. Combined activities of JNK1 and JNK2 in hepatocytes protect against toxic liver injury. Gastroenterology. 2016;150:968–81.
Article
CAS
Google Scholar
Wang L, Zhang W, Ge CH, Yin RH, Xiao Y, Zhan YQ, Yu M, Li CY, Ge ZQ, Yang XM. Toll-like receptor 5 signaling restrains T-cell/natural killer T-cell activation and protects against concanavalin A-induced hepatic injury. Hepatology. 2017;65:2059–73.
Article
CAS
Google Scholar
M.W. Wang X, Fang C, Tian S, Zhu X, Yang L, Huang Z, Li H, Dusp14 protects against hepatic ischemia-reperfusion injury via Tak1 suppression. J Hepatol. 2017;S0168-8278(17):32275-4.
Nakao T, Ono Y, Dai H, Nakano R, Perez-Gutierrez A, Camirand G, Huang H, Geller DA, Thomson AW. DNAX activating protein of 12 kDa/triggering receptor expressed on myeloid cells 2 expression by mouse and human liver dendritic cells: functional implications and regulation of liver ischemia-reperfusion injury. Hepatology. 2019;70:696–710.
Article
CAS
Google Scholar
Qiao H, Zhou Y, Qin X, Cheng J, He Y, Jiang Y. NADPH oxidase signaling pathway mediates Mesenchymal stem cell-induced inhibition of hepatic stellate cell activation. Stem Cells Int. 2018;2018:1239143.
Article
Google Scholar
Jia FF, Tan ZR, McLeod HL, Chen Y, Ou-Yang DS, Zhou HH. Effects of quercetin on pharmacokinetics of cefprozil in Chinese-Han male volunteers. Xenobiotica. 2016;46:896–900.
Article
CAS
Google Scholar
Tzankova V, Aluani D, Kondeva-Burdina M, Yordanov Y, Odzhakov F, Apostolov A, Yoncheva K. Hepatoprotective and antioxidant activity of quercetin loaded chitosan/alginate particles in vitro and in vivo in a model of paracetamol-induced toxicity. Biomed Pharmacother. 2017;92:569–79.
Article
CAS
Google Scholar
Gupta V, Sharma R, Bansal P, Kaur G. Bioactivity-guided isolation of potent anxiolytic compounds from leaves of Citrus paradisi. Ayu. 2018;39:21–8.
Article
Google Scholar
Dra LA, Sellami S, Rais H, Aziz F, Aghraz A, Bekkouche K, Markouk M, Larhsini M. Antidiabetic potential of Caralluma europaea against alloxan-induced diabetes in mice. Saudi J Biol Sci. 2019;26:1171–8.
Article
CAS
Google Scholar
Chen FY, Cao LF, Wan HX, Zhang MY, Cai JY, Shen LJ, Zhong JH, Zhong H. Quercetin enhances adriamycin cytotoxicity through induction of apoptosis and regulation of mitogen-activated protein kinase/extracellular signal-regulated kinase/c-Jun N-terminal kinase signaling in multidrug-resistant leukemia K562 cells. Mol Med Rep. 2015;11:341–8.
Article
CAS
Google Scholar
Daglioglu C. Enhancing tumor cell response to multidrug resistance with pH-sensitive Quercetin and doxorubicin conjugated multifunctional nanoparticles. Colloids Surf B Biointerfaces. 2017;156:175–85.
Article
CAS
Google Scholar
Li X, Jin Q, Yao Q, Xu B, Li L, Zhang S, Tu C. The flavonoid Quercetin ameliorates liver inflammation and fibrosis by regulating hepatic macrophages activation and polarization in mice. Front Pharmacol. 2018;9:72.
Article
Google Scholar
Wu L, Zhang Q, Mo W, Feng J, Li S, Li J, Liu T, Xu S, Wang W, Lu X, Yu Q, Chen K, Xia Y, Lu J, Xu L, Zhou Y, Fan X, Guo C. Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF-beta1/Smads and PI3K/Akt pathways. Sci Rep. 2017;7:9289.
Article
Google Scholar
Varshosaz J, Jafarian A, Salehi G, Zolfaghari B. Comparing different sterol containing solid lipid nanoparticles for targeted delivery of quercetin in hepatocellular carcinoma. J Liposome Res. 2014;24:191–203.
Article
CAS
Google Scholar
Karimi-Khouzani O, Heidarian E, Amini SA. Anti-inflammatory and ameliorative effects of gallic acid on fluoxetine-induced oxidative stress and liver damage in rats. Pharmacol Rep. 2017;69:830–5.
Article
CAS
Google Scholar