Béjot Y, Daubail B, Giroud M. Epidemiology of stroke and transient ischemic attacks: current knowledge and perspectives. Rev Neurol (Paris). 2016;172(1):59–68. https://doi.org/10.1016/j.neurol.2015.07.013.
Article
Google Scholar
Lee RHC, Lee MHH, Wu CYC, Couto E Silva A, Possoit HE, Hsieh TH, et al. Cerebral ischemia and neuroregeneration. Neural Regen Res. 2018;13(3):373–85. https://doi.org/10.4103/1673-5374.228711.
Article
PubMed
PubMed Central
Google Scholar
Siniscalchi A, Gallelli L, Malferrari G, Pirritano D, Serra R, Santangelo E, et al. Cerebral stroke injury: the role of cytokines and brain inflammation. J Basic Clin Physiol Pharmacol. 2014;25(2):131–7. https://doi.org/10.1515/jbcpp-2013-0121.
Article
CAS
PubMed
Google Scholar
Cheng C-Y, Lee Y-C. Anti-inflammatory effects of traditional Chinese medicines against ischemic injury in in vivo models of cerebral ischemia. Evid Based Complement Alternat Med. 2016;2016:5739434–16. https://doi.org/10.1155/2016/5739434.
Article
PubMed
PubMed Central
Google Scholar
Lambertsen KL, Biber K, Finsen B. Inflammatory cytokines in experimental and human stroke. J Cereb Blood Flow Metab. 2012;32(9):1677–98. https://doi.org/10.1038/jcbfm.2012.88.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wang Q, Qi J, Hu R, Chen Y, Kijlstra A, Yang P. Effect of berberine on proinflammatory cytokine production by ARPE-19 cells following stimulation with tumor necrosis factor-α. Invest Ophthalmol Vis Sci. 2012;53(4):2395–402. https://doi.org/10.1167/iovs.11-8982.
Article
PubMed
Google Scholar
Srivastava S, Srivastava M, Misra A, Pandey G, Rawat A. A review on biological and chemical diversity in Berberis (Berberidaceae). EXCLI J. 2015;14:247–67. https://doi.org/10.17179/excli2014-399.
Article
PubMed
PubMed Central
Google Scholar
Kim M, Kim TW, Kim CJ, Shin MS, Hong M, Park HS, et al. Berberine ameliorates brain inflammation in Poloxamer 407-induced Hyperlipidemic rats. Int Neurourol J. 2019;23(Suppl 2):S102–10. https://doi.org/10.5213/inj.1938216.108.
Article
PubMed
PubMed Central
Google Scholar
Zhang Q, et al. Treatment effects of ischemic stroke by Berberine, Baicalin, and Jasminoidin from Huang-Lian-Jie-Du-decoction (HLJDD) explored by an integrated metabolomics approach. Oxidative Med Cell Longev. 2017;2017:9848594.
Google Scholar
Yuan NN, Cai CZ, Wu MY, Su HX, Li M, Lu JH. Neuroprotective effects of berberine in animal models of Alzheimer’s disease: a systematic review of pre-clinical studies. BMC Complement Altern Med. 2019;19(1):109. https://doi.org/10.1186/s12906-019-2510-z.
Article
PubMed
PubMed Central
Google Scholar
Tong L, Xie C, Wei Y, Qu Y, Liang H, Zhang Y, et al. Antitumor effects of Berberine on gliomas via inactivation of Caspase-1-mediated IL-1β and IL-18 release. Front Oncol. 2019;9:364. https://doi.org/10.3389/fonc.2019.00364.
Article
PubMed
PubMed Central
Google Scholar
Tan J, Wang J, Yang C, Zhu C, Guo G, Tang J, et al. Antimicrobial characteristics of Berberine against prosthetic joint infection-related Staphylococcus aureus of different multi-locus sequence types. BMC Complement Altern Med. 2019;19(1):218. https://doi.org/10.1186/s12906-019-2558-9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Rajasekhar K, et al. Antioxidant Berberine-Derivative Inhibits Multifaceted Amyloid Toxicity. iScience. 2020;23(4):101005.
Article
CAS
Google Scholar
Botwina P, Owczarek K, Rajfur Z, Ochman M, Urlik M, Nowakowska M, et al. Berberine hampers influenza a replication through inhibition of MAPK/ERK pathway. Viruses. 2020;12(3):344. https://doi.org/10.3390/v12030344.
Article
CAS
PubMed Central
Google Scholar
Wang CY, Bai XY, Wang CH. Traditional Chinese medicine: a treasured natural resource of anticancer drug research and development. Am J Chin Med. 2014;42(3):543–59. https://doi.org/10.1142/S0192415X14500359.
Article
CAS
PubMed
Google Scholar
Chen W, Miao YQ, Fan DJ, Yang SS, Lin X, Meng LK, et al. Bioavailability study of Berberine and the enhancing effects of TPGS on intestinal absorption in rats. AAPS PharmSciTech. 2011;12(2):705–11. https://doi.org/10.1208/s12249-011-9632-z.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zuo F, Nakamura N, Akao T, Hattori M. Pharmacokinetics of berberine and its main metabolites in conventional and pseudo germ-free rats determined by liquid chromatography/ion trap mass spectrometry. Drug Metab Dispos. 2006;34(12):2064–72. https://doi.org/10.1124/dmd.106.011361.
Article
CAS
PubMed
Google Scholar
Feng R, Zhao ZX, Ma SR, Guo F, Wang Y, Jiang JD. Gut microbiota-regulated pharmacokinetics of Berberine and active metabolites in beagle dogs after Oral administration. Front Pharmacol. 2018;9:214. https://doi.org/10.3389/fphar.2018.00214.
Article
CAS
PubMed
PubMed Central
Google Scholar
Tsai P, Tsai TH. Simultaneous determination of berberine in rat blood, liver and bile using microdialysis coupled to high-performance liquid chromatography. J Chromatogr A. 2002;961(1):125–30. https://doi.org/10.1016/S0021-9673(02)00378-3.
Article
CAS
PubMed
Google Scholar
Wang Z, Guo X, Liu Z, Cui M, Song F, Liu S. Studies on alkaloids binding to GC-rich human survivin promoter DNA using positive and negative ion electrospray ionization mass spectrometry. J Mass Spectrom. 2008;43(3):327–35. https://doi.org/10.1002/jms.1320.
Article
CAS
PubMed
Google Scholar
Wang Z, et al. Berberine-loaded Janus nanocarriers for magnetic field-enhanced therapy against hepatocellular carcinoma. Chem Biol Drug Design. 2017;89(3):464–9.
Article
CAS
Google Scholar
Yu F, Ao M, Zheng X, Li N, Xia J, Li Y, et al. PEG-lipid-PLGA hybrid nanoparticles loaded with berberine-phospholipid complex to facilitate the oral delivery efficiency. Drug Delivery. 2017;24(1):825–33. https://doi.org/10.1080/10717544.2017.1321062.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wang T, Wang N, Song H, Xi X, Wang JA, Hao A, et al. Preparation of an anhydrous reverse micelle delivery system to enhance oral bioavailability and anti-diabetic efficacy of berberine. Eur J Pharma Sci. 2011;44(1-2):127–35. https://doi.org/10.1016/j.ejps.2011.06.015.
Article
CAS
Google Scholar
Chen W, Wei S, Yu Y, Xue H, Yao F, Zhang M, et al. Pretreatment of rats with increased bioavailable berberine attenuates cerebral ischemia-reperfusion injury via down regulation of adenosine-5'monophosphate kinase activity. Eur J Pharmacol. 2016;779:80–90. https://doi.org/10.1016/j.ejphar.2016.03.015.
Article
CAS
PubMed
Google Scholar
Fakhraei N, et al. Berberine nanomicelles attenuate cirrhotic cardiomyopathy in rats: possible involvement of the NO-cGMP signaling. Nanomed J. 2020;7(4):299–307.
CAS
Google Scholar
Luo JW, Zhang ZR, Gong T, Fu Y. One-step self-assembled nanomicelles for improving the oral bioavailability of nimodipine. Int J Nanomedicine. 2016;11:1051–65. https://doi.org/10.2147/IJN.S97834.
Article
CAS
PubMed
PubMed Central
Google Scholar
Parikh A, Kathawala K, Song Y, Zhou XF, Garg S. Curcumin-loaded self-nanomicellizing solid dispersion system: part I: development, optimization, characterization, and oral bioavailability. Drug Deliv Transl Res. 2018;8(5):1389–405. https://doi.org/10.1007/s13346-018-0543-3.
Article
CAS
PubMed
Google Scholar
Jin Q, Cai Y, Li S, Liu H, Zhou X, Lu C, et al. Edaravone-encapsulated agonistic micelles rescue ischemic brain tissue by tuning blood-brain barrier permeability. Theranostics. 2017;7(4):884–98. https://doi.org/10.7150/thno.18219.
Article
CAS
PubMed
PubMed Central
Google Scholar
Patra JK, Das G, Fraceto LF, Campos EVR, Rodriguez-Torres MP, Acosta-Torres LS, et al. Nano based drug delivery systems: recent developments and future prospects. J Nanobiotechnol. 2018;16(1):71. https://doi.org/10.1186/s12951-018-0392-8.
Article
CAS
Google Scholar
Gaucher G, Satturwar P, Jones MC, Furtos A, Leroux JC. Polymeric micelles for oral drug delivery. Eur J Pharm Biopharm. 2010;76(2):147–58. https://doi.org/10.1016/j.ejpb.2010.06.007.
Article
CAS
PubMed
Google Scholar
Salimi A, Sharif B, Esfahani G. Polymeric micelle as a new carrier in Oral drug delivery systems. Asian J Pharma. 2017;11:S704.
CAS
Google Scholar
Ai X, Zhong L, Niu H, He Z. Thin-film hydration preparation method and stability test of DOX-loaded disulfide-linked polyethylene glycol 5000-lysine-di-tocopherol succinate nanomicelles. Asian J Pharma Sci. 2014;9(5):244–50. https://doi.org/10.1016/j.ajps.2014.06.006.
Article
Google Scholar
Nik ME, Malaekeh-Nikouei B, Amin M, Hatamipour M, Teymouri M, Sadeghnia HR, et al. Liposomal formulation of Galbanic acid improved therapeutic efficacy of pegylated liposomal doxorubicin in mouse colon carcinoma. Sci Rep. 2019;9(1):9527. https://doi.org/10.1038/s41598-019-45974-7.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hatamipour M, Sahebkar A, Alavizadeh SH, Dorri M, Jaafari MR. Novel nanomicelle formulation to enhance bioavailability and stability of curcuminoids. Iran J Basic Med Sci. 2019;22(3):282–9. https://doi.org/10.22038/ijbms.2019.32873.7852.
Article
PubMed
PubMed Central
Google Scholar
Turner PV, Brabb T, Pekow C, Vasbinder MA. Administration of substances to laboratory animals: routes of administration and factors to consider. J Am Assoc Lab Anim Sci. 2011;50(5):600–13.
CAS
PubMed
PubMed Central
Google Scholar
Partoazar A, Nasoohi S, Rezayat SM, Gilani K, Mehr SE, Amani A, et al. Nanoliposome containing cyclosporine a reduced neuroinflammation responses and improved neurological activities in cerebral ischemia/reperfusion in rat. Fundam Clin Pharmacol. 2017;31(2):185–93. https://doi.org/10.1111/fcp.12244.
Article
CAS
PubMed
Google Scholar
Farbiszewski R, Bielawski K, Bielawska A, Sobaniec W. Spermine protects in vivo the antioxidant enzymes in transiently hypoperfused rat brain. Acta Neurobiol Exp (Wars). 1995;55(4):253–8.
CAS
Google Scholar
Chen YF, Wang YW, Huang WS, Lee MM, Wood WG, Leung YM, et al. Trans-Cinnamaldehyde, an essential oil in cinnamon powder, ameliorates cerebral ischemia-induced brain injury via inhibition of Neuroinflammation through attenuation of iNOS, COX-2 expression and NFκ-B signaling pathway. NeuroMolecular Med. 2016;18(3):322–33. https://doi.org/10.1007/s12017-016-8395-9.
Article
CAS
PubMed
Google Scholar
Nayak VS, Kumar N, D’Souza AS, Nayak SS, Cheruku SP, Pai KSR. The effects of Mucuna pruriens extract on histopathological and biochemical features in the rat model of ischemia. Neuroreport. 2017;28(18):1195–201. https://doi.org/10.1097/WNR.0000000000000888.
Article
PubMed
Google Scholar
Maleki SN, Aboutaleb N, Souri F. Berberine confers neuroprotection in coping with focal cerebral ischemia by targeting inflammatory cytokines. J Chem Neuroanat. 2018;87:54–9. https://doi.org/10.1016/j.jchemneu.2017.04.008.
Article
CAS
PubMed
PubMed Central
Google Scholar
Singh DP, Chopra K. Verapamil augments the neuroprotectant action of berberine in rat model of transient global cerebral ischemia. Eur J Pharmacol. 2013;720(1):98–106. https://doi.org/10.1016/j.ejphar.2013.10.043.
Article
CAS
PubMed
Google Scholar
Yousefi-Manesh H, Rashidian A, Hemmati S, Shirooie S, Sadeghi MA, Zarei N, et al. Therapeutic effects of modafinil in ischemic stroke; possible role of NF-κB downregulation. Immunopharmacol Immunotoxicol. 2019;41(5):558–64. https://doi.org/10.1080/08923973.2019.1669045.
Article
CAS
PubMed
Google Scholar
Simões SM, Figueiras AR, Veiga F, Concheiro A, Alvarez-Lorenzo C. Polymeric micelles for oral drug administration enabling locoregional and systemic treatments. Expert Opin Drug Deliv. 2015;12(2):297–318. https://doi.org/10.1517/17425247.2015.960841.
Article
CAS
PubMed
Google Scholar
Li C, Li X. Development and validation of a method for determination of encapsulation efficiency of CPT-11/DSPE-mPEG2000 nanoparticles. Med Chem. 2016;6(05):1–4. https://doi.org/10.4172/2161-0444.1000368.
Article
CAS
Google Scholar
Wu L, Xiong X, Wu X, Ye Y, Jian Z, Zhi Z, et al. Targeting oxidative stress and inflammation to prevent ischemia-reperfusion injury. Front Mol Neurosci. 2020;13:28. https://doi.org/10.3389/fnmol.2020.00028.
Article
CAS
PubMed
PubMed Central
Google Scholar