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Table 3 Effect of the tested drugs on mean blood pressure in alloxan-induced diabetic rats

From: Therapeutic activity of sarpogrelate and dopamine D2 receptor agonists on cardiovascular and renal systems in rats with alloxan-induced diabetes

Mean Blood Pressure MBP (mmHg)
Groups Week 1 Week 2 Week 3 Week 4
Normal control group 110 ± 4.01 118.25 ± 8.99 108.75 ± 4.57 111.5 ± 4.20
Diabetic control group 112.5 ± 9.14 121.75 ± 11.35 150.75 ± 5.25* 151.25 ± 5.12*
Diabetic group treated with bromocriptine 115 ± 9.12 102.75 ± 6.8 109 ± 10.23# 121.75 ± 15.26#
Diabetic group treated with cabergoline 103.75 ± 7.0 105.5 ± 9.14 123 ± 7.87# 107.75 ± 107.75#
Diabetic group treated with sarpogrelate 118.75 ± 10.87 114.75 ± 8.53 137.75 ± 8.53 139 ± 18.56
Diabetic group treated with bromocriptine + sarpogrelate 104.5 ± 7.59 104.75 ± 4.99 106.25 ± 11.08# 118 ± 13.03#
Diabetic group treated with cabergoline + sarpogrelate 109.25 ± 11.58 105 ± 9.05 106 ± 18.3# 104.25 ± 5.5#
  1. Values shown are means ± SEM; n = 6 rats per group. * P < 0.05, significantly different from the normal control group; # P < 0.05, significantly different from the diabetic control group