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Table 3 Effect of the tested drugs on mean blood pressure in alloxan-induced diabetic rats

From: Therapeutic activity of sarpogrelate and dopamine D2 receptor agonists on cardiovascular and renal systems in rats with alloxan-induced diabetes

Mean Blood Pressure MBP (mmHg)

Groups

Week 1

Week 2

Week 3

Week 4

Normal control group

110 ± 4.01

118.25 ± 8.99

108.75 ± 4.57

111.5 ± 4.20

Diabetic control group

112.5 ± 9.14

121.75 ± 11.35

150.75 ± 5.25*

151.25 ± 5.12*

Diabetic group treated with bromocriptine

115 ± 9.12

102.75 ± 6.8

109 ± 10.23#

121.75 ± 15.26#

Diabetic group treated with cabergoline

103.75 ± 7.0

105.5 ± 9.14

123 ± 7.87#

107.75 ± 107.75#

Diabetic group treated with sarpogrelate

118.75 ± 10.87

114.75 ± 8.53

137.75 ± 8.53

139 ± 18.56

Diabetic group treated with bromocriptine + sarpogrelate

104.5 ± 7.59

104.75 ± 4.99

106.25 ± 11.08#

118 ± 13.03#

Diabetic group treated with cabergoline + sarpogrelate

109.25 ± 11.58

105 ± 9.05

106 ± 18.3#

104.25 ± 5.5#

  1. Values shown are means ± SEM; n = 6 rats per group. * P < 0.05, significantly different from the normal control group; # P < 0.05, significantly different from the diabetic control group