Fig. 10

Photomicrograph of tissue _liver and kidney section stained with H and E and a magnification: × 400; depicting alterations in the tissue of rats exposed to environmentally relevant concentrations of lead (PbAC3) and furan for 28 consecutive days. Column 1: Control: Liver and kidney tissue histoarchitecture were typical without unusual characteristics. The liver sinusoids appear normal and not infiltrated. However, there is a significant presence of inflammatory cells in the kidney. Column 2: Furan alone: Liver and kidney sections appear normal, with the renal cortex showing normal glomeruli, mesangial cells and capsular spaces (red arrow). Also, the renal tubules appear normal (black arrow), and the interstitial spaces appear normal (slender arrow). Column 3: Lead alone: Liver: the morphology of the hepatocytes at zone 3 shows spongy and balloon-like cytoplasm (red arrow), while other liver cells appear normal (black arrow). The hepatic sinusoids appear normal and without infiltration of any cell type. The kidney showed poor architecture at a lower magnification (× 100) image not shown, and the renal cortex showed normal glomeruli with normal mesangial cells and capsular spaces (black arrowheads) with collapsed renal tubules (red arrow). The interstitial spaces show the focal area of accumulated eosinophilic fluid (slender red arrow). Column 4–6: Furan and Pb with varying doses (1–3): Liver histoarchitecture of Pb1-3: progressive congestion around the portal vein (black arrow) was observed in the liver of the experimental rats, while the morphology of the sinusoids appears normal without any significant infiltration by inflammatory cells. The kidney histoarchitecture remains intact, and the renal cortex shows normal glomeruli with normal mesangial cells and capsular spaces (black arrow). The renal tubules and the interstitial spaces appear normal (red arrow)