Accidental lead in contaminated pipe-borne water and dietary furan intake perturbs rats’ hepatorenal function altering oxidative, inflammatory, and apoptotic balance

Table 1 Effect of the co-administration of furan and lead acetate on the body weight, organ weight and relative organ weight of experimental rats

	Control	Furan	PbAc	Fur + PbAc₁	Fur + PbAc₂	Fur + PbAc₃
IBW (g)	152.60 ± 11.24	189.00 ± 10.34	193.60 ± 11.15	180.40 ± 9.71	169.80 ± 4.15	174.60 ± 3.58
FBW (g)	231.75 ± 18.80^#	257.00 ± 7.00^#	265.80 ± 8.53^#	249.40 ± 15.47^#	229.00 ± 14.78^#	233.50 ± 12.50^#
Weight gain (g)	79.20 ± 12.50	71.00 ± 6.60	69.20 ± 5.50	69.00 ± 7.91	59.20 ± 16.18	57.40 ± 14.05
Liver weight (g)	6.84 ± 1.00	7.72 ± 1.24^*	7.68 ± 0.64	8.38 ± 0.77	8.72 ± 1.35	7.40 ± 0.93
Kidney Weight (g)	1.38 ± 0.15	1.40 ± 0.21^*	1.60 ± 0.25	1.60 ± 0.13	1.44 ± 0.17	1.56 ± 0.22
RLW (%)	3.04 ± 0.19	3.73 ± 0.54	2.89 ± 0.21	3.36 ± 0.14	3.80 ± 0.51	3.21 ± 0.53
RKW (%)	0.62 ± 0.06	0.54 ± 0.09	0.60 ± 0.09	0.64 ± 0.02	0.63 ± 0.10	0.67 ± 0.09

FUR (8 mg/kg), PbAc (100 µg/kg b.w.), PbAc₁ (1 µg/kg b.w.), PbAc₂ (10 µg/kg b.w.), PbAc₃ (100 µg/kg b.w.); n = 5. Data are expressed as mean ± SD
Fur Furan, IBW Initial body weight, FBW Final Body weight, RLW Relative liver weight, RKW Relative kidney weight
(IBW versus FBW: ^#p < 0.05)
(Control versus Furan or PbAc: ^*p < 0.05)

ISSN: 2050-6511