Volume 14 Supplement 1

6th International Conference on cGMP: Generators, Effectors and Therapeutic Implications

Meeting abstracts

Edited by John C Burnett Jr, Franz Hofmann, Kazuwa Nakao, Harald HHW Schmidt and Johannes-Peter Stasch

Publication of this supplement has been fully funded by Bayer Pharma AG. Johannes-Peter Stasch is an employee of Bayer Pharma AG, Wuppertal, Germany. He holds many patents on sGC stimulators and sGC activators. John C Burnett Jr is the chairman of the advisory board for Nile Therapeutics and is a Co-Founder and the Chief Scientific Officer for Zumbro Discovery. Mayo Clinic has licensed CD-NP to Nile Therapeutics and MANP to Zumbro Discovery. The other Supplement Editors declare that they have no competing interests.

6th International Conference on cGMP: Generators, Effectors and Therapeutic Implications. Go to conference site.

Erfurt, Germany28-30 June 2013

Page 3 of 3

Function of cGMP-dependent protein kinase II in volume expansion-induced diuresis

Authors: Andrea Schramm, Elisabeth Schinner and Jens Schlossmann

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P63

Content type: Poster presentation Published on: 29 August 2013
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Endothelial dysfunction in a mouse model of human neutral lipid storage disease

Authors: Astrid Schrammel, Marion Mussbacher, Gerald Wölkart, Heike Stessel, Günter Hämmerle, Wael Al Zoughbi, Gerald Höfler, Alois Lametschwandtner, Rudolf Zechner and Bernd Mayer

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P64

Content type: Poster presentation Published on: 29 August 2013
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Discovery of neuroprotective soluble guanylate cyclase modulators (GCMs) aciting via NO/GC/cGMP/CREB pathway

Authors: Marton I Siklos, Ronak P Gandhi, Rui Xiong, Isaac T Schiefer, Vladislav Litosh, Lawren VandeVrede and Gregory RJ Thatcher

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P65

Content type: Poster presentation Published on: 29 August 2013
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Genetic silencing of sGC β1 in cancer: role of epigenetic regulation

Authors: Alex Sotolongo, Ka Bian and Ferid Murad

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P66

Content type: Poster presentation Published on: 29 August 2013
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Krait natriuretic peptide (KNP): a non-classical NP

Authors: Sindhuja Sridharan and R Manjunatha Kini

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P67

Content type: Poster presentation Published on: 29 August 2013
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Cardiac cGMP/cGMP-dependent protein kinase I signalling requires cysteine-rich LIM-only protein 4 (CRP4) to oppose angiotensin II induced hypertrophy and fibrosis

Authors: Julia Straubinger, Peter Ruth and Robert Lukowski

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P68

Content type: Poster presentation Published on: 29 August 2013
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Differential regulation of platelet inhibition by cGMP- and cAMP-dependent protein kinases

Authors: Hariharan Subramanian, Ulrich Walter and Stepan Gambaryan

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P69

Content type: Poster presentation Published on: 29 August 2013
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Linaclotide induces secretion of cGMP from mouse colonic epithelium

Authors: Boris Tchernychev, Sarah Jacobson, Caroline Kurtz, Mark Currie and Inmaculada Silos-Santiago

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P70

Content type: Poster presentation Published on: 29 August 2013
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Receptor guanylyl cyclase B-mediated cGMP signalling controls axon bifurcation of cranial sensory ganglion neurons at the embryonic hindbrain

Authors: Gohar Ter-Avetisyan, Fritz G Rathjen and Hannes Schmidt

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P71

Content type: Poster presentation Published on: 29 August 2013
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NO/cGMP/pCREB re-activation reverses cognition deficits and attenuates amyloid-β neuropathology in transgenic models of Alzheimer’s disease

Authors: Gregory RJ Thatcher, Jia Luo, Lawren VandeVrede, Zhihui Qin, Sue Lee, Ramy Abdelhamid, Brian M Bennett, Mary Jo LaDu, Leon Tai and John Larson

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P72

Content type: Poster presentation Published on: 29 August 2013
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Endothelial GC-A can be a therapeutic target for metabolic syndrome

Authors: Takeshi Tokudome, Kentaro Otani, Ichiro Kishimoto, Yuanjie Mao, Kazuwa Nakao and Kenji Kangawa

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P73

Content type: Poster presentation Published on: 29 August 2013
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Phospho-specific antisera to monitor N-terminal autophosphorylation of cGMP-dependent protein kinase type I

Authors: Raghavan Vallur, Hubert Kalbacher, Jana Krauß and Robert Feil

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P74

Content type: Poster presentation Published on: 29 August 2013
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The soluble guanylate cyclase activator BAY 58-2667 protects against morbidity and mortality in endotoxic shock by recoupling organ systems

Authors: Benjamin Vandendriessche, Elke Rogge, Vera Goossens, Peter Vandenabeele, Johannes-Peter Stasch, Peter Brouckaert and Anje Cauwels

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P75

Content type: Poster presentation Published on: 29 August 2013
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Analysis of cGMP signalling with transgenic mice expressing FRET-based cGMP sensors

Authors: Lai Wen, Martin Thunemann, Susanne Feil, Matthias Hillenbrand, Angelos Vachaviolos, Thomas Ott, Xiaoxing Han, Dai Fukumura, Rakesh K Jain, Cor de Wit, Michael Russwurm and Robert Feil

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P76

Content type: Poster presentation Published on: 29 August 2013
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Genes involved in pulmonary hypertension of mice with endothelial-specific ablation of guanylyl cyclase A

Authors: Franziska Werner, Katharina Völker, Claus-Jürgen Scholz, Margarethe Goebel, Michael Seimetz, Baktybek Kojonazarov, Kai Schuh, Bhola K Dahal, Ralph T Schermuly, Heike Oberwinkler, Birgit Gaßner and Michaela Kuhn

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P77

Content type: Poster presentation Published on: 29 August 2013
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Identification of cCMP binding and activated proteins

Authors: Stefanie Wolfertstetter, Elisabeth Schinner, Franz Hofmann and Jens Schlossmann

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P78

Content type: Poster presentation Published on: 29 August 2013
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Activation profile of cGMP-dependent protein kinase Iα

Authors: Sabine Wolter, Marina Golombek, Frank Schwede, Hans-Gottfried Genieser, Stefan Dove and Roland Seifert

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P79

Content type: Poster presentation Published on: 29 August 2013
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Anti-interleukin-6 therapy for treatment of high platelet counts in cGMP-dependent protein kinase I gene-targeted mice

Authors: Lin Zhang, Robert Lukowski, Florian Gaertner, Michael Lorenz, Kyle R Legate, Katrin Domes, Elisabeth Angermeier, Franz Hofmann and Steffen Massberg

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P80

Content type: Poster presentation Published on: 29 August 2013
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6th International Conference on cGMP: Generators, Effectors and Therapeutic Implications

Meeting abstracts

Function of cGMP-dependent protein kinase II in volume expansion-induced diuresis

Endothelial dysfunction in a mouse model of human neutral lipid storage disease

Discovery of neuroprotective soluble guanylate cyclase modulators (GCMs) aciting via NO/GC/cGMP/CREB pathway

Genetic silencing of sGC β1 in cancer: role of epigenetic regulation

Krait natriuretic peptide (KNP): a non-classical NP

Cardiac cGMP/cGMP-dependent protein kinase I signalling requires cysteine-rich LIM-only protein 4 (CRP4) to oppose angiotensin II induced hypertrophy and fibrosis

Differential regulation of platelet inhibition by cGMP- and cAMP-dependent protein kinases

Linaclotide induces secretion of cGMP from mouse colonic epithelium

Receptor guanylyl cyclase B-mediated cGMP signalling controls axon bifurcation of cranial sensory ganglion neurons at the embryonic hindbrain

NO/cGMP/pCREB re-activation reverses cognition deficits and attenuates amyloid-β neuropathology in transgenic models of Alzheimer’s disease

Endothelial GC-A can be a therapeutic target for metabolic syndrome

Phospho-specific antisera to monitor N-terminal autophosphorylation of cGMP-dependent protein kinase type I

The soluble guanylate cyclase activator BAY 58-2667 protects against morbidity and mortality in endotoxic shock by recoupling organ systems

Analysis of cGMP signalling with transgenic mice expressing FRET-based cGMP sensors

Genes involved in pulmonary hypertension of mice with endothelial-specific ablation of guanylyl cyclase A

Identification of cCMP binding and activated proteins

Activation profile of cGMP-dependent protein kinase Iα

Anti-interleukin-6 therapy for treatment of high platelet counts in cGMP-dependent protein kinase I gene-targeted mice

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