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  1. Content type: Study protocol

    It is well known that the standard doses of a given drug may not have equivalent effects in all patients. To date, the management of depression remains mainly empirical and often poorly evaluated. The developm...

    Authors: Célia Lloret-Linares, Youssef Daali, Sylvie Chevret, Isabelle Nieto, Fanny Molière, Philippe Courtet, Florence Galtier, Raphaëlle-Marie Richieri, Sophie Morange, Pierre-Michel Llorca, Wissam El-Hage, Thomas Desmidt, Frédéric Haesebaert, Philippe Vignaud, Jerôme Holtzmann, Jean-Luc Cracowski…

    Citation: BMC Pharmacology and Toxicology 2017 18:70

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  2. Content type: Research article

    Prescription practices, especially in South Asian countries, have come under investigation for quality. Although there have been no studies in Nepal that have analyzed the prescription pattern of FDCs for diff...

    Authors: Arjun Poudel, Mohamed Izham Mohamed Ibrahim, Pranaya Mishra and Subish Palaian

    Citation: BMC Pharmacology and Toxicology 2017 18:69

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  3. Content type: Research article

    Older people have a greater disease burden and are more likely than younger to be prescribed medications. They are also more sensitive to adverse effects. With this in mind, a range of medications have been su...

    Authors: Anna Axmon, Magnus Sandberg, Gerd Ahlström and Patrik Midlöv

    Citation: BMC Pharmacology and Toxicology 2017 18:68

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  4. Content type: Research article

    Hyperglycemia-induced advanced glycation end products (AGEs) and receptor for AGEs (RAGE) production play major roles in progression of diabetic nephropathy. Anti-RAGE effect of peroxisome proliferator-activat...

    Authors: Jui-Ting Chang, Yao-Jen Liang, Chia-Yu Hsu, Chao-Yi Chen, Po-Jung Chen, Yi-Feng Yang, Yen-Lin Chen, Dee Pei, Jin-Biou Chang and Jyh-Gang Leu

    Citation: BMC Pharmacology and Toxicology 2017 18:67

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  5. Content type: Research article

    Vildagliptin and pioglitazone/rosiglitazone are emerging Oral Hypoglycemic Agents (OHAs) which are used to treat patients suffering from Type 2 Diabetes Mellitus (T2DM). In this analysis, we aimed to systemati...

    Authors: Pravesh Kumar Bundhun, Girish Janoo, Abhishek Rishikesh Teeluck and Feng Huang

    Citation: BMC Pharmacology and Toxicology 2017 18:66

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  6. Content type: Research article

    The presentation of schizophrenia (SCH) symptoms differs between the sexes. Long-term treatment with antipsychotics is frequently associated with decreased bone mineral density, increased fracture risk and met...

    Authors: Tatjana Nikolić, Milan Petronijević, Jelena Sopta, Milica Velimirović, Tihomir Stojković, Gordana Jevtić Dožudić, Milan Aksić, Nevena V. Radonjić and Nataša Petronijević

    Citation: BMC Pharmacology and Toxicology 2017 18:65

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  7. Content type: Meeting abstracts

    Authors: G. Todd Milne, Peter Sandner, Kathleen A. Lincoln, Paul C. Harrison, Hongxing Chen, Hong Wang, Holly Clifford, Hu Sheng Qian, Diane Wong, Chris Sarko, Ryan Fryer, Jeremy Richman, Glenn A. Reinhart, Carine M. Boustany, Steven S. Pullen, Henriette Andresen…

    Citation: BMC Pharmacology and Toxicology 2017 18(Suppl 1):64

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    This article is part of a Supplement: Volume 18 Supplement 1

  8. Content type: Research article

    Our previous studies demonstrated that growth and migration of medulloblastoma (MB), the most common malignant brain tumor in children, are stimulated by 17β-estradiol. The growth stimulating effects of estrog...

    Authors: Scott M. Belcher, Caleb C. Burton, Clifford J. Cookman, Michelle Kirby, Gabriel L. Miranda, Fatima O. Saeed and Kathleen E. Wray

    Citation: BMC Pharmacology and Toxicology 2017 18:63

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  9. Content type: Research article

    Thiazolidinediones (TZDs), peroxisome proliferator-activated receptor-γ (PPAR-γ) agonists, exhibit anti-inflammatory and antioxidant properties and inhibit endothelial inflammation and dysfunction, which is an...

    Authors: Yun Hyi Ku, Bong-Jun Cho, Min Joo Kim, Soo Lim, Young Joo Park, Hak C. Jang and Sung Hee Choi

    Citation: BMC Pharmacology and Toxicology 2017 18:62

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  10. Content type: Research article

    Taurolidine has been used for peritonitis, oncological and catheter-lock treatment because of its anti-inflammatory properties. It has been suggested that taurolidine has no severe side-effects, but after long...

    Authors: René Fahrner, Anika Möller, Adrian T. Press, Andreas Kortgen, Michael Kiehntopf, Falk Rauchfuss, Utz Settmacher and Alexander S. Mosig

    Citation: BMC Pharmacology and Toxicology 2017 18:61

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  11. Content type: Research article

    Intracellular Ca2+ overload induced by extracellular Ca2+ entry has previously been confirmed to be an important mechanism for the cardiotoxicity as well as the acute heart dysfunction induced by jellyfish venom,...

    Authors: Qianqian Wang, Hui Zhang, Bo Wang, Chao Wang, Liang Xiao and Liming Zhang

    Citation: BMC Pharmacology and Toxicology 2017 18:60

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  12. Content type: Research article

    Polypharmacy is a reality in long-term care facilities. However, number of medications used by the patient should not be the only predictor of a complex pharmacotherapy. Although the level of complexity of pha...

    Authors: Vanessa Alves-Conceição, Daniel Tenório da Silva, Vanessa Lima de Santana, Edileide Guimarães dos Santos, Lincoln Marques Cavalcante Santos and Divaldo Pereira de Lyra Jr.

    Citation: BMC Pharmacology and Toxicology 2017 18:59

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  13. Content type: Research article

    With the re-popularity of metal-on-metal (MoM) bearing in recent years, the cobalt toxicity has been a cause for concern in the total hip replacement surgery by both physicians and patients.

    Authors: Dahe Li, Wenwen Tong, Denghui Liu, Yuming Zou, Chen Zhang and Weidong Xu

    Citation: BMC Pharmacology and Toxicology 2017 18:58

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  14. Content type: Research article

    Isoliquiritigenin (ISL) has various biological activities including as antioxidant and an inhibitor of PI3K/AKT signaling pathway. However, both oxidative stress and activated PI3K/AKT signaling contribute to ...

    Authors: Tianbao Chen, Shaoxiong Deng and Rong Lin

    Citation: BMC Pharmacology and Toxicology 2017 18:57

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  15. Content type: Study protocol

    An estimated 2.7 of the 5.9 million deaths in children under 5 years of age occur in the neonatal period. Severe infections contribute to almost a quarter of these deaths. Mortality due to severe infections in...

    Authors: Nitya Wadhwa, Sudha Basnet, Uma Chandra Mouli Natchu, Laxman P. Shrestha, Shinjini Bhatnagar, Halvor Sommerfelt, Tor A. Strand, Siddarth Ramji, K. C. Aggarwal, Harish Chellani, Anuradha Govil, Mamta Jajoo, N. B. Mathur, Meenakshi Bhatt, Anup Mohta, Imran Ansari…

    Citation: BMC Pharmacology and Toxicology 2017 18:56

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  16. Content type: Research article

    Mitiglinide is a widely used agent for diabetic treatment. We established a pharmacokinetic-pharmacodynamic (PK-PD) model to illustrate the relationship between mitiglinide plasma concentration and its glucose...

    Authors: Shijia Liu, Peidong Chen, Yang Zhao, Guoliang Dai, Bingting Sun, Yao Wang, Anwei Ding and Wenzheng Ju

    Citation: BMC Pharmacology and Toxicology 2017 18:54

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  17. Content type: Research article

    In order to obtain better clinical results in anticancer therapies, polychemotherapy or combination therapies are used. For this, the combinations are required to increase the efficacy and reduce the adverse r...

    Authors: Mariana de Oliveira Mauro, Renata Matuo, Natan de David, Regiane Lauriano Batista Strapasson, Rodrigo Juliano Oliveira, Maria Élida Alves Stefanello, Cândida Aparecida Leite Kassuya, Maria de Fátima de Cepa Matos, Fábio José Carvalho Faria and Deiler Sampaio Costa

    Citation: BMC Pharmacology and Toxicology 2017 18:53

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  18. Content type: Research article

    The present study investigates changes in spontaneous reporting (SR) compliance and ADR patterns following adoption of a new hospital SR system, and multiple interventions designed for its improvement use unde...

    Authors: Huan Fang, Xiaowen Lin, Jun Zhang, Zhen Hong, Kenji Sugiyama, Takao Nozaki, Tetsuro Sameshima, Susumu Kobayashi, Hiroki Namba and Tetsuya Asakawa

    Citation: BMC Pharmacology and Toxicology 2017 18:49

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  19. Content type: Research article

    E2HSA is a genetic fusion protein that consists of two tandem exendin-4 molecules that are covalently bonded to recombinant human serum albumin via a peptide linker. Previous studies have demonstrated that E2H...

    Authors: Caina Li, Shaocong Hou, Shuainan Liu, Yi Huan, Sujuan Sun, Quan Liu and Zhufang Shen

    Citation: BMC Pharmacology and Toxicology 2017 18:48

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  20. Content type: Research article

    The COP9 signalosome (CSN) is a conserved protein complex composed of 8 subunits designated CSN1-CSN8. CSN3 represents the third subunit of the CSN and maintains the integrity of the complex. CSN3 binds to the...

    Authors: Mariam A. Ba, Jeffrey Surina, Cherie A. Singer and Maria L. Valencik

    Citation: BMC Pharmacology and Toxicology 2017 18:47

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  21. Content type: Research article

    Environmental chemical-induced perturbations of gut microbiome are associated with a series of adverse health outcomes. The effects of triclosan on human health have been controversial in recent years. The pur...

    Authors: Bei Gao, Pengcheng Tu, Xiaoming Bian, Liang Chi, Hongyu Ru and Kun Lu

    Citation: BMC Pharmacology and Toxicology 2017 18:46

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  22. Content type: Research article

    Increased pain sensitivity is a putative risk factor for chronic pain and consequently for analgesic use. Conversely, analgesic use may be a cause of increased pain sensitivity, e.g., through opioid-induced hy...

    Authors: Per-Jostein Samuelsen, Christopher Sivert Nielsen, Tom Wilsgaard, Audun Stubhaug, Kristian Svendsen and Anne Elise Eggen

    Citation: BMC Pharmacology and Toxicology 2017 18:45

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  23. Content type: Research article

    The expanded use of multiple drugs has increased the occurrence of adverse drug reactions (ADRs) induced by drug-drug interactions (DDIs). However, such reactions are typically not observed in clinical drug-de...

    Authors: Ruifeng Liu, Mohamed Diwan M. AbdulHameed, Kamal Kumar, Xueping Yu, Anders Wallqvist and Jaques Reifman

    Citation: BMC Pharmacology and Toxicology 2017 18:44

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  24. Content type: Research article

    Fabry disease (FD) is an X-linked lysosomal storage disorder resulting from the α-galactosidase A gene mutations. Enzyme-replacement-therapy (ERT) products for FD currently used include agalsidase alfa and aga...

    Authors: Kazuya Tsuboi and Hiroshi Yamamoto

    Citation: BMC Pharmacology and Toxicology 2017 18:43

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  25. Content type: Research article

    Exposure to chemicals might be toxic to the developing brain. There is a need for simple and robust in vitro cellular models for evaluation of chemical-induced neurotoxicity as a complement to traditional stud...

    Authors: Dina Popova, Jessica Karlsson and Stig O. P. Jacobsson

    Citation: BMC Pharmacology and Toxicology 2017 18:42

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  26. Content type: Case report

    Tardive akathisia (TA) is a subtype of tardive syndrome, and its etiology is still uncertain. Sevikar is an anti-hypertensive agent containing both amlodipine and olmesartan, and has never been reported to hav...

    Authors: Men-Ting Hsieh, Pao-Yen Lin, Chia-Jen Tsai, Chiung-Chih Chang and Yu Lee

    Citation: BMC Pharmacology and Toxicology 2017 18:41

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  27. Content type: Research article

    Protein ubiquitylation is an important post-translational regulation, which has been shown to be necessary for life cycle progression and survival of Plasmodium falciparum. Ubiquitin is a highly conserved 76 amin...

    Authors: Jagrati Jain, Surendra K. Jain, Larry A. Walker and Babu L. Tekwani

    Citation: BMC Pharmacology and Toxicology 2017 18:40

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  28. Content type: Research article

    Metformin associated lactic acidosis (MALA) is a rare but lethal complication. There is no consensus regarding when to stop and resume metformin in patients who undergo coronary artery bypass grafting (CABG). ...

    Authors: Rakan I. Nazer and Khalid A. Alburikan

    Citation: BMC Pharmacology and Toxicology 2017 18:38

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  29. Content type: Research article

    We recently reported that hesperetin-5,7,3’-O-triacetate (HTA) dually inhibited phosphodiesterase (PDE)3/4 with a therapeutic ratio of 20.8. The application and development of PDE4 inhibitors for treating asthma ...

    Authors: You-Lan Yang, Chi-Li Chen, Chi-Ming Chen and Wun-Chang Ko

    Citation: BMC Pharmacology and Toxicology 2017 18:39

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  30. Content type: Research article

    Psychotropic drugs are common among old people with dementia, and have been associated with increased mortality. Previous studies have not investigated sex differences in this risk. This study was conducted to...

    Authors: Jon Brännström, Gustaf Boström, Erik Rosendahl, Peter Nordström, Håkan Littbrand, Hugo Lövheim and Yngve Gustafson

    Citation: BMC Pharmacology and Toxicology 2017 18:36

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  31. Content type: Case report

    Run Rat® is a rodenticide widely used against small mammals. It comprises of a minimum of 32% zinc phosphide which is highly toxic in acute exposures to humans. It may be consumed accidentally or intentionally...

    Authors: Nilukshana Yogendranathan, H. M. M. T. B. Herath, Thenuka Sivasundaram, R. Constantine and Aruna Kulatunga

    Citation: BMC Pharmacology and Toxicology 2017 18:37

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  32. Content type: Research article

    Drug-resistant microorganism are a growing global danger. Strains of S. aureus have developed resistance to many commonly used antimicrobials due to indiscriminate use of antimicrobials, and treatment becoming a ...

    Authors: Serawit Deyno, Alemayehu Toma, Mesfin Worku and Muluken Bekele

    Citation: BMC Pharmacology and Toxicology 2017 18:35

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  33. Content type: Research article

    Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) such as gefitinib can provide better efficacy and prolonged progression free survival (PFS) than cytotoxic chemotherapy for metastatic lung ...

    Authors: Chih-Jen Yang, Jen-Yu Hung, Ming-Ju Tsai, Kuan-Li Wu, Ta-Chih Liu, Shah-Hwa Chou, Jui-Ying Lee, Jui-Sheng Hsu, Ming-Shyan Huang and Inn-Wen Chong

    Citation: BMC Pharmacology and Toxicology 2017 18:21

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  34. Content type: Research article

    The aim of this study is to identify the distribution by municipalities of adverse drug events (ADE) in Portugal, including adverse drug reactions (ADR) and accidental poisoning by drugs (AP), on municipality/...

    Authors: Gianina Scripcaru, Ceu Mateus and Carla Nunes

    Citation: BMC Pharmacology and Toxicology 2017 18:34

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  35. Content type: Research article

    Diacetyl-liensinine is a chemosynthetic derivative of liensinine, extracted from the seed embryo of Nelumbo nucifera Gaertn, in China. It has been found to have extensive anti- arrhythmic actions. The present stu...

    Authors: Feng Cao, Teng Wang, Wenmao Ding, Zhe Li, Shaobo Shi and Xiaozhan Wang

    Citation: BMC Pharmacology and Toxicology 2017 18:33

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  36. Content type: Research article

    Drug interactions between antiretroviral drugs (ARVs) and anthelminthic drugs, ivermectin (IVM) and praziquantel (PZQ) were assessed by investigating their permeation through the Caco-2 cell monolayers in a tr...

    Authors: Gabriel Kigen and Geoffrey Edwards

    Citation: BMC Pharmacology and Toxicology 2017 18:20

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  37. Content type: Research article

    Cardol is a major bioactive constituent in the Trigona incisa propolis from Indonesia, with a strong in vitro antiproliferative activity against the SW620 colorectal adenocarcinoma cell line (IC50 of 4.51 ± 0.76 ...

    Authors: Paula Mariana Kustiawan, Kriengsak Lirdprapamongkol, Tanapat Palaga, Songchan Puthong, Preecha Phuwapraisirisan, Jisnuson Svasti and Chanpen Chanchao

    Citation: BMC Pharmacology and Toxicology 2017 18:32

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  38. Content type: Research article

    Poor drug quality is a matter of serious concern, especially in countries where drug regulation and law enforcement are constrained by limited resources. This study was carried out to investigate the cause of ...

    Authors: Mohammad Sofiqur Rahman, Naoko Yoshida, Hirohito Tsuboi, Tep Keila, Tey Sovannarith, Heng Bun Kiet, Eav Dararth, Theingi Zin, Tsuyoshi Tanimoto and Kazuko Kimura

    Citation: BMC Pharmacology and Toxicology 2017 18:31

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  39. Content type: Research article

    Promiscuity in molecular interactions between small-molecules, including drugs, and proteins is widespread. Such unintended interactions can be exploited to suggest drug repurposing possibilities as well as to...

    Authors: Matthieu Chartier, Louis-Philippe Morency, María Inés Zylber and Rafael J. Najmanovich

    Citation: BMC Pharmacology and Toxicology 2017 18:18

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  40. Content type: Research article

    Vascular disease is a common and often severe complication in diabetes mellitus. Hyperglycemia and hypertension are considered to be two of the leading risk factors for vascular complications in diabetic patie...

    Authors: Yu-Guang Ma, Jun-Wei Wang, Yun-Gang Bai, Mei Liu, Man-Jiang Xie and Zhi-Jun Dai

    Citation: BMC Pharmacology and Toxicology 2017 18:30

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  41. Content type: Research article

    The present study was designed to investigate the protective effect of aqueous date extract (ADE) against the dichloroacetic acid (DCA)-induced testicular injury in rats.

    Authors: Amira El Arem, Lamia Lahouar, Emna Behija Saafi, Amira Thouri, Fatma Ghrairi, Zohra Houas, Fadoua Neffati and Lotfi Achour

    Citation: BMC Pharmacology and Toxicology 2017 18:17

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  42. Content type: Research article

    The objective of the present study aimed to investigate the effect of CoQ10 treatment on isoprenaline (ISO)-induced cardiac remodeling in rats.

    Authors: Anayt Ulla, Mustafe Khalid Mohamed, Biswajit Sikder, AFM Towheedur Rahman, Farzana Akther Sumi, Murad Hossain, Hasan Mahmud Reza, G. M. Sayedur Rahman and Md Ashraful Alam

    Citation: BMC Pharmacology and Toxicology 2017 18:29

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  43. Content type: Research article

    Nowadays, canagliflozin monotherapy, or in combination with other oral hypoglycemic agents (OHAs), is often administered in patients who are treated for type 2 diabetes mellitus (T2DM). Therefore, we aimed to ...

    Authors: Pravesh Kumar Bundhun, Girish Janoo and Feng Huang

    Citation: BMC Pharmacology and Toxicology 2017 18:19

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  44. Content type: Research article

    Sodium-glucose cotransporter 2 (SGLT2) inhibitors are reported to have BP-lowering effect in addition to blood glucose-lowering effect, however, its mechanism is still unknown. This study aimed to investigate ...

    Authors: Shin Kawasoe, Yukiko Maruguchi, Shoko Kajiya, Hitoshi Uenomachi, Masaaki Miyata, Mariko Kawasoe, Takuro Kubozono and Mitsuru Ohishi

    Citation: BMC Pharmacology and Toxicology 2017 18:23

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  45. Content type: Research article

    Genetic variation of matrix metalloproteinase 9 (MMP-9) gene polymorphism has been suggested to modulate coronary heart diseases (CHD), yet the underlying mechanisms are not well understood.

    Authors: Yuanyuan Xu, Yan Wang, Jixin Zhi, Lichun Qi, Tong Zhang and Xueqi Li

    Citation: BMC Pharmacology and Toxicology 2017 18:28

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  46. Content type: Research article

    Adherence to prescribed medication is an imperative issue which can be directly linked with the management of chronic diseases like hypertension; failure to adhere can affect the effectiveness of medication as...

    Authors: Habtamu Sewunet Mekonnen, Mignote Hailu Gebrie, Kokeb Haile Eyasu and Abebaw Addis Gelagay

    Citation: BMC Pharmacology and Toxicology 2017 18:27

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Reviewer acknowledgments