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82 result(s) within Volume 24 of BMC Pharmacology and Toxicology

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  1. Many trials supported pembrolizumab as a first-line monotherapy to significantly improve overall survival (OS) in selected patients with previously untreated metastatic Non–Small Cell Lung Cancer (mNSCLC) and ...

    Authors: Lisa Faoro, Adriana Brusegan, Alberto Russi, Vincenzo Calderone, Alma Martelli, Ettore Marranconi, Debora Carpanese, Elena Berti and Marina Coppola
    Citation: BMC Pharmacology and Toxicology 2023 24:32
    Content type: Research article Published on:

  2. Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic hepatic disorder. The naturally occurring phytosterol; β-sitosterol has antiobesogenic and anti-diabetic properties. The purpose of this s...

    Authors: Omayma AR Abo-Zaid, Fatma SM Moawed, Effet Soliman Ismail and Mostafa A. Farrag
    Citation: BMC Pharmacology and Toxicology 2023 24:31
    Content type: Research Published on:

  4. First-generation epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), such as erlotinib, have been shown to target tumors with L858R (exon 21) and exon 19 deletions, resulting in significan...

    Authors: Xiangdan Cuan, Xingying Yang, Weiwei Zhu, Yue Zhao, Rui Luo, Yanping Huang, Xuanjun Wang and Jun Sheng
    Citation: BMC Pharmacology and Toxicology 2023 24:29
    Content type: Research Published on:

  5. Stroke is one of the most common noncommunicable diseases, with significant public health implications both globally and in Malaysia. The aim of this study was to evaluate post-stroke survivability as well as ...

    Authors: Monica Danial, Nurul Shahira Izwani Mohdradzi, Amer Hayat Khan, Alan Swee Hock Ch’ng and Looi Irene
    Citation: BMC Pharmacology and Toxicology 2023 24:28
    Content type: Research Published on:

  6. Atopic dermatitis (AD) is a chronic inflammatory skin disease that affects from children to adults widely, presenting symptoms such as pruritus, erythema, scaling, and dryness. Lupeol, a pentacyclic triterpeno...

    Authors: Sojung Bae, Na-Hee Jeong, Young-Ae Choi, Byungheon Lee, Yong Hyun Jang, Soyoung Lee and Sang-Hyun Kim
    Citation: BMC Pharmacology and Toxicology 2023 24:27
    Content type: Research Published on:

  7. Medical therapies can cause cardiotoxicity. Chloroquine (QC) and hydroxychloroquine (HQC) are drugs used in the treatment of malaria and skin and rheumatic disorders. These drugs were considered to help treatm...

    Authors: Enayatollah Seydi, Mozhgan Karbalaei Hassani, Saghi Naderpour, Abdollah Arjmand and Jalal Pourahmad
    Citation: BMC Pharmacology and Toxicology 2023 24:26
    Content type: Research Published on:

  8. Previous studies on animal models have suggested that δ-opioid receptor (OR) signaling is the primary pathway responsible for opioids' cardioprotective effect. We hypothesize that the μ-OR's activation protect...

    Authors: Marcin Kunecki, Tomasz Oleksy, Jan Martynów, Michalina Zygmunt, Marek Deja, Tomasz Kargul, Jolanta Biernat, Piotr Podolec, Krzysztof S. Gołba and Wojciech Płazak
    Citation: BMC Pharmacology and Toxicology 2023 24:25
    Content type: Research Published on:

  9. Renin–angiotensin–aldosterone system (RAAS) is hypothesized to be in the center of COVID pathophysiology as the angiotensin converting enzyme 2 (ACE2) represents the main entrance of the virus, thus there is a...

    Authors: Sarah Farid fahmy, Marwa Omar El Derany, Hazem Khorshid, Ayman Saleh and Ebtehal El-Demerdash
    Citation: BMC Pharmacology and Toxicology 2023 24:24
    Content type: Research Published on:

  10. Standard doses of second-generation H1-antihistamines (sgAHs) as first-line treatment are not always effective in treating chronic spontaneous urticaria (CSU), and hence an increase in the dose of sgAHs is recomm...

    Authors: Xianjun Xiao, Peiwen Xue, Yunzhou Shi, Junpeng Yao, Wei Cao, Leixiao Zhang, Zihao Zou, Siyuan Zhou, Chuan Wang, Mingling Chen, Rongjiang Jin, Ying Li and Qianhua Zheng
    Citation: BMC Pharmacology and Toxicology 2023 24:23
    Content type: Research Published on:

  11. Since the warnings by the United States (US) and European regulatory authorities in 2004 and 2005 it had been discussed whether there is some link between selective serotonin reuptake inhibitors (SSRIs) and su...

    Authors: Diana Dubrall, Stefanie Fekete, Sarah Leitzen, Lena Marie Paschke, Marcel Romanos, Matthias Schmid, Manfred Gerlach and Bernhardt Sachs
    Citation: BMC Pharmacology and Toxicology 2023 24:22
    Content type: Research Published on:

  12. Oral insulin administration has recently become one of the most exciting research subjects. Different approaches have been carried out to get an effective oral insulin delivery system using nanotechnology. The...

    Authors: Mohamed M. Fathy, Asmaa A. Hassan, Anwar A. Elsayed and Heba M. Fahmy
    Citation: BMC Pharmacology and Toxicology 2023 24:21
    Content type: Research Published on:

  13. The anti-osteosarcoma effects of hydrocortisone and thiram, an inhibitor of type 2 11ß-hydroxysteroid dehydrogenase (11HSD2), have not been reported. The purpose of this study was to investigate the effects of...

    Authors: You Zhang, Nanjing Li, He Li, Maojia Chen, Wei Jiang and Wenhao Guo
    Citation: BMC Pharmacology and Toxicology 2023 24:20
    Content type: Research Published on:

  14. The severe unfavorable effects of doxorubicin on the heart restrict its clinical usage. Numerous investigations document that cyclic GMP-AMP synthase (cGAS) activator of interferon genes (STING) cascade influe...

    Authors: Zilong Xiao, Ziqing Yu, Chaofeng Chen, Ruizhen Chen and Yangang Su
    Citation: BMC Pharmacology and Toxicology 2023 24:19
    Content type: Research Published on:

  16. Anabolic steroids (AS) are commonly abused by body builders and athletes aiming to increase their strength and muscle mass but unfortunately, the long-term use of AS may lead to serious side effects. Nandrolon...

    Authors: Dalia Abd Elwahab Hassan, Sherien S. Ghaleb, Amr reda Zaki, Ahmed Abdelmenem, Shimaa Nabil and Mostafa Abdallah Abdel Alim
    Citation: BMC Pharmacology and Toxicology 2023 24:17
    Content type: Research Published on:

  17. Cisplatin is a widely used and effective chemotherapeutic agent for most solid malignant tumors. However, cisplatin-induced ototoxicity is a common adverse effect that limits the therapeutic efficacy of tumors...

    Authors: Haiyan Wang, Hanqing Lin, Weibiao Kang, Lingfei Huang, Sisi Gong, Tao Zhang, Xiaotong Huang, Feinan He, Yongyi Ye, Yiyang Tang, Haiying Jia and Haidi Yang
    Citation: BMC Pharmacology and Toxicology 2023 24:16
    Content type: Research Published on:

  18. Osteonecrosis of the jaw (ONJ) is a rare but serious adverse drug reaction (ADR) commonly associated with bisphosphonate and denosumab therapy. Prior research utilized an online, public FDA Adverse Event Repor...

    Authors: Hardeep S. Ahdi, Thomas Adam Wichelmann, Sasirekha Pandravada and Eli D. Ehrenpreis
    Citation: BMC Pharmacology and Toxicology 2023 24:15
    Content type: Research article Published on:

  19. Voriconazole is a second-generation triazole that is used to prevent and treat invasive fungal infections. The purpose of this study was to evaluate the pharmacokinetic equivalency of a test formulation and re...

    Authors: Xin Li, Chenjing Wang, Ping Shi, Yanping Liu, Ye Tao, Pingping Lin, Ting Li, Haixun Hu, Feifei Sun, Shuqin Liu, Yao Fu and Yu Cao
    Citation: BMC Pharmacology and Toxicology 2023 24:14
    Content type: Research Published on:

  20. Albumin-bound paclitaxel (nab-paclitaxel), as a special targeted preparation of paclitaxel, has the advantages of good curative effect and less side effects in anti-tumor therapy. The existence of the plasma-p...

    Authors: Jingjing Zhang, Luya Li, Jintuo Yin, Xidong Zhang, Ying Zheng and Rui Feng
    Citation: BMC Pharmacology and Toxicology 2023 24:13
    Content type: Research Published on:

  21. Chlorine is a chemical threat agent that can be harmful to humans. Inhalation of high levels of chlorine can lead to acute lung injury (ALI). Currently, there is no satisfactory treatment, and effective antido...

    Authors: Meng-meng Liu, Jiang-zheng Liu, Chen-qian Zhao, Peng Guo, Zhao Wang, Hao Wu, Weihua Yu, Rui Liu, Chun-xu Hai and Xiao-di Zhang
    Citation: BMC Pharmacology and Toxicology 2023 24:12
    Content type: Research Published on:

  22. Neurotoxicity is a severe side effect of platinum compounds used for cancer chemotherapy such as Cisplatin. This neurotoxicity leads to severe cognitive and nervous dysfunction, therefore, limiting the dose of...

    Authors: Eman A. Khalil, Hamdy Swelim, Hala El-Tantawi and Ahmed Abdellatif
    Citation: BMC Pharmacology and Toxicology 2023 24:11
    Content type: Research Published on:

  23. The study was aimed at evaluating the bioequivalence and safety of oseltamivir phosphate for suspension, provided by Shenzhen Beimei Pharmaceutical Co. Ltd. and manufactured by Hetero Labs Limited, and the ref...

    Authors: Ying Wang, Bangzhong Tang, Jing Xie, Xiaoqin Wang, Peng Ren, Guangmei Wu, Cuixia He, Minhui Zhu, Yue Su, Jiaxiang Ding, Yuanyuan Xu, Ling Fan, Qin Ge, Yuzhou Ding, Juan Zhu, Bingyan Liu…
    Citation: BMC Pharmacology and Toxicology 2023 24:10
    Content type: Research Published on:

  24. Seizures are considered to be the most common symptom encountered in emergency- rushed tramadol-poisoned patients; accounting for 8% of the drug-induced seizure cases. Although, diazepam clears these seizures,...

    Authors: Shaimaa A. ElShebiney, Rania Elgohary, Sayed H. Kenawy, Gehan T. El-Bassyouni and Esmat M. A. Hamzawy
    Citation: BMC Pharmacology and Toxicology 2023 24:9
    Content type: Research Published on:

  25. WIN55, 212–2 mesylate is a synthetic cannabinoid (SC) agonist of CB1 and CB2 receptors with much higher affinity to CB1 receptor than tetrahydrocannabinol and many potential therapeutic effects. Few studies ha...

    Authors: Ghada A. Omran, Eman S. H. Abd Allah, Sherine Ahmed Mohammed and Doaa M. El Shehaby
    Citation: BMC Pharmacology and Toxicology 2023 24:8
    Content type: Research Published on:

  26. Ezetimibe is a new class of antihyperlipidemic agent indicated for the prevention of atherosclerosis disease and for the treatment of hypercholesterolemia. Information on the pharmacokinetic profiles of ezetim...

    Authors: Feifei Sun, Yanping Liu, Ting Li, Pingping Lin, Xin Jiang, Xin Li, Chenjing Wang, Xiaomeng Gao, Yaping Ma, Yao Fu and Yu Cao
    Citation: BMC Pharmacology and Toxicology 2023 24:7
    Content type: Research article Published on:

  27. Poisoning is a major health problem especially in developing countries and leads to high morbidity and mortality.

    Authors: Omar El-Sayed Rageh, Hamdy Khaled Sabra, Abdulrahman Abdullah Alammar, Omar Naif Alanazi, Ayman Nagy and Ibrahim Ali Kabbash
    Citation: BMC Pharmacology and Toxicology 2023 24:6
    Content type: Research Published on:

  28. Glycyrrhetinic acid (GA) is a bio-effective component of Licorice. The GA is a monomer and the ingredient is an Oleanane-type pentacyclic triterpenes that has been used as a remedy for years. Due to the abuse ...

    Authors: Piaoyi Guo, Liang Jin, Huifen Zhou, Yida Bao, Jiehong Yang, Jing Chen, Yu He, Daojun Yu and Haitong Wan
    Citation: BMC Pharmacology and Toxicology 2023 24:5
    Content type: Research Published on:

  30. Regulations have broadened to allow moderate sedation administration for gastrointestinal endoscopy by non-anesthesia personnel. The line between moderate and deep sedation is ambiguous. Deep sedation offers p...

    Authors: Jing-Yang Liou, I-Ting Kuo, Weng-Kuei Chang, Chien-Kun Ting and Mei-Yung Tsou
    Citation: BMC Pharmacology and Toxicology 2023 24:3
    Content type: Research Published on:

  31. The literature recommends against the use of fondaparinux in patients with kidney failure and dialysis as it may, with repeated dosing, accumulate and put patients at risk of bleeding. The management of patien...

    Authors: Dania Ghaziri, Hassan Dehaini, Mayyas Msheik, Marwan Bahmad, Maya Zorkot and George Abi Saad
    Citation: BMC Pharmacology and Toxicology 2023 24:2
    Content type: Research Published on:

  32. Doxorubicin (DOX) is a broad-spectrum anti-tumor drug, but its clinical application is greatly limited because of the cardiotoxicity. Thus, exploration of effective therapies against DOX-induced cardiotoxicity...

    Authors: Chenjun Shen, Bo Yang, Lili Huang, Yueru Chen, Huajun Zhao and Zhihui Zhu
    Citation: BMC Pharmacology and Toxicology 2023 24:1
    Content type: Research Published on:

    The Correction to this article has been published in BMC Pharmacology and Toxicology 2023 24:18

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