Articles
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Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P79
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Genes involved in pulmonary hypertension of mice with endothelial-specific ablation of guanylyl cyclase A
Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P77 -
Video microscopy as a tool to visualize cGMP effects on contractility and sperm transport in seminiferous tubules and the epididymal duct
Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P44 -
Pseudomonas aeruginosaExoY, a cyclic GMP- and cyclic UMP-generating nucleotidyl cyclase
Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O36 -
NO-cGMP signalling and cancer therapy
Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P9 -
Absorption behavior of riociguat: bioavailability, food effects, and dose-proportionality
Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P7 -
Memory loss during lenalidomide treatment: a report on two cases
There are many reports of cognitive dysfunction in patients receiving chemotherapy or targeted therapies. Many antineoplastic agents may be involved in the condition also known as “chemo brain” or “chemo fog”.
Citation: BMC Pharmacology and Toxicology 2013 14:41 -
Anakinra pharmacokinetics in children and adolescents with systemic-onset juvenile idiopathic arthritis and autoinflammatory syndromes
Anakinra pharmacokinetics and pharmacodynamics were investigated in children and adolescents treated for systemic-onset juvenile idiopathic arthritis (SJIA) and autoinflammatory syndromes.
Citation: BMC Pharmacology and Toxicology 2013 14:40 -
The association between prescription change frequency, chronic disease score and hospital admissions: a case control study
The aim of this study was to assess the association between prescription changes frequency (PCF) and hospital admissions and to compare the PCF to the Chronic Disease Score (CDS). The CDS measures comorbidity ...
Citation: BMC Pharmacology and Toxicology 2013 14:39 -
Olanzapine in pregnancy and breastfeeding: a review of data from global safety surveillance
Olanzapine use has been reported during pregnancy and breastfeeding, but there are no controlled clinical trials assessing the safety of olanzapine exposure to infants and fetuses. The purpose of this report w...
Citation: BMC Pharmacology and Toxicology 2013 14:38 -
Polycomblike protein PHF1b: a transcriptional sensor for GABA receptor activity
The γ-aminobutyric acid (GABA) type A receptor (GABAAR) contains the recognition sites for a variety of agents used in the treatment of brain disorders, including anxiety and epilepsy. A better understanding of h...
Citation: BMC Pharmacology and Toxicology 2013 14:37 -
Coumestrol from the national cancer Institute’s natural product library is a novel inhibitor of protein kinase CK2
Casein kinase 2 (CK2) is involved in various cellular events such as proliferation, apoptosis, and the cell cycle. CK2 overexpression is associated with multiple human cancers and may therefore be a promising ...
Citation: BMC Pharmacology and Toxicology 2013 14:36 -
Distinct single cell signal transduction signatures in leukocyte subsets stimulated with khat extract, amphetamine-like cathinone, cathine or norephedrine
Amphetamine and amphetamine derivatives are suggested to induce an immunosuppressive effect. However, knowledge of how amphetamines modulate intracellular signaling pathways in cells of the immune system is li...
Citation: BMC Pharmacology and Toxicology 2013 14:35 -
Quantitation of small intestinal permeability during normal human drug absorption
Understanding the quantitative relationship between a drug’s physical chemical properties and its rate of intestinal absorption (QSAR) is critical for selecting candidate drugs. Because of limited experimental...
Citation: BMC Pharmacology and Toxicology 2013 14:34 -
Effects of packaging and storage conditions on the quality of amoxicillin-clavulanic acid – an analysis of Cambodian samples
The use of substandard and degraded medicines is a major public health problem in developing countries such as Cambodia. A collaborative study was conducted to evaluate the quality of amoxicillin–clavulanic ac...
Citation: BMC Pharmacology and Toxicology 2013 14:33 -
Efficacy of RNA polymerase II inhibitors in targeting dormant leukaemia cells
Dormant cells are characterised by low RNA synthesis. In contrast, cancer cells can be addicted to high RNA synthesis, including synthesis of survival molecules. We hypothesised that dormant cancer cells, alre...
Citation: BMC Pharmacology and Toxicology 2013 14:32 -
Computational analysis of protein-protein interfaces involving an alpha helix: insights for terphenyl–like molecules binding
Protein-Protein Interactions (PPIs) are key for many cellular processes. The characterization of PPI interfaces and the prediction of putative ligand binding sites and hot spot residues are essential to design...
Citation: BMC Pharmacology and Toxicology 2013 14:31 -
Adverse drug reactions reported by consumers for nervous system medications in Europe 2007 to 2011
Reporting of adverse drug reactions (ADRs) has traditionally been the sole province of healthcare professionals. In the European Union, more countries have allowed consumers to report ADRs directly to the regu...
Citation: BMC Pharmacology and Toxicology 2013 14:30 -
Comprehensive database of Chorismate synthase enzyme from shikimate pathway in pathogenic bacteria
Infectious diseases are major public health problem. It is increasingly affecting more than 50 million people worldwide. Targeting shikimate pathway could be efficiently used for the development of broad spect...
Citation: BMC Pharmacology and Toxicology 2013 14:29 -
Treatment with CNX-011-67, a novel GPR40 agonist, delays onset and progression of diabetes and improves beta cell preservation and function in male ZDF rats
The role of G protein-coupled receptor (GPR40), which is highly expressed in pancreatic beta cells, has been studied extensively in the amelioration of beta cell dysfunction in T2D using rat and mouse islets, ...
Citation: BMC Pharmacology and Toxicology 2013 14:28 -
First human dose-escalation study with remogliflozin etabonate, a selective inhibitor of the sodium-glucose transporter 2 (SGLT2), in healthy subjects and in subjects with type 2 diabetes mellitus
Remogliflozin etabonate (RE) is the prodrug of remogliflozin, a selective inhibitor of the renal sodium-dependent glucose transporter 2 (SGLT2), which could increase urine glucose excretion (UGE) and lower pla...
Citation: BMC Pharmacology and Toxicology 2013 14:26 -
Rifampicin-warfarin interaction leading to macroscopic hematuria: a case report and review of the literature
Rifampicin remains one of the first-line drugs used in tuberculosis therapy. This drug´s potential to induce the hepatic cytochrome P450 oxidative enzyme system increases the risk of drug-drug interactions. Th...
Citation: BMC Pharmacology and Toxicology 2013 14:27 -
Safety, pharmacokinetics and pharmacodynamics of remogliflozin etabonate, a novel SGLT2 inhibitor, and metformin when co-administered in subjects with type 2 diabetes mellitus
The sodium-dependent glucose co-transporter-2 (SGLT2) is expressed in absorptive epithelia of the renal tubules. Remogliflozin etabonate (RE) is the prodrug of remogliflozin, the active entity that inhibits SG...
Citation: BMC Pharmacology and Toxicology 2013 14:25 -
Annual acknowledgement of manuscript reviewers
In August 2012 the BMC Series journals BMC Clinical Pharmacology and BMC Pharmacology merged to form a new title BMC Pharmacology and Toxicology. The editors of BMC Clinical Pharmacology and BMC Pharmacology w...
Citation: BMC Pharmacology and Toxicology 2013 14:21 -
Pharmaceutical quality of seven generic Levodopa/Benserazide products compared with original Madopar® / Prolopa®
By definition, a generic product is considered interchangeable with the innovator brand product. Controversy exists about interchangeability, and attention is predominantly directed to contaminants. In particu...
Citation: BMC Pharmacology and Toxicology 2013 14:24 -
Role of astrocytes in manganese mediated neurotoxicity
Astrocytes are responsible for numerous aspects of metabolic support, nutrition, control of the ion and neurotransmitter environment in central nervous system (CNS). Failure by astrocytes to support essential ...
Citation: BMC Pharmacology and Toxicology 2013 14:23 -
The prognostic value of blood pH and lactate and metformin concentrations in severe metformin-associated lactic acidosis
Analysis of the prognostic values of blood pH and lactate and plasma metformin concentrations in severe metformin-associated lactic acidosis may help to resolve the following paradox: metformin provides impres...
Citation: BMC Pharmacology and Toxicology 2013 14:22 -
Scottish and Newcastle Antiemetic Pre-treatment for paracetamol poisoning study (SNAP)
Paracetamol (acetaminophen) poisoning remains the commonest cause of acute liver injury in Europe and North America. The intravenous (IV) N-acetylcysteine (NAC) regimen introduced in the 1970s has continued ef...
Citation: BMC Pharmacology and Toxicology 2013 14:20 -
Cotrimoxazole plasma levels, dialyzer clearance and total removal by extended dialysis in a patient with acute kidney injury: risk of under-dosing using current dosing recommendations
Dosing of antibiotics in critically ill patients is challenging. It becomes even more difficult if renal or hepatic impairment ensue. Modern means of renal replacement therapy are capable of removing antibioti...
Citation: BMC Pharmacology and Toxicology 2013 14:19 -
Anvirzel™ in combination with cisplatin in breast, colon, lung, prostate, melanoma and pancreatic cancer cell lines
Platinum derivatives are used widely for the treatment of many cancers. However, the toxicity that is observed makes imperative the need for new drugs, or new combinations. Anvirzel™ is an extract which has be...
Citation: BMC Pharmacology and Toxicology 2013 14:18 -
Label-free integrative pharmacology on-target of opioid ligands at the opioid receptor family
In vitro pharmacology of ligands is typically assessed using a variety of molecular assays based on predetermined molecular events in living cells. Many ligands including opioid ligands pose the ability to bind ...
Citation: BMC Pharmacology and Toxicology 2013 14:17 -
Attitudes among healthcare professionals to the reporting of adverse drug reactions in Nepal
Healthcare professional’s knowledge and attitudes to adverse drug reaction (ADR) and ADR reporting play vital role to report any cases of ADR. Positive attitudes may favour ADR reporting by healthcare professi...
Citation: BMC Pharmacology and Toxicology 2013 14:16 -
Bioenergetic study of murine hepatic tissue treated in vitro with atorvastatin
Atorvastatin (a 3-hydroxy-3-methylglutaryl coenzyme-A reductase inhibitor) is a widely used cholesterol-lowering drug, which is recognized for its potential hepatotoxicity. This study investigated in vitro effect...
Citation: BMC Pharmacology and Toxicology 2013 14:15 -
Safety, tolerability, pharmacokinetics and pharmacodynamics of GSK2239633, a CC-chemokine receptor 4 antagonist, in healthy male subjects: results from an open-label and from a randomised study
The CC-chemokine receptor 4 (CCR4) is thought potentially to play a critical role in asthma pathogenesis due to its ability to recruit type 2 T-helper lymphocytes to the inflamed airways. Therefore, CCR4 provi...
Citation: BMC Pharmacology and Toxicology 2013 14:14 -
In utero exposure to low dose arsenic via drinking water impairs early life lung mechanics in mice
Exposure to arsenic via drinking water is a significant environmental issue affecting millions of people around the world. Exposure to arsenic during foetal development has been shown to impair somatic growth ...
Citation: BMC Pharmacology and Toxicology 2013 14:13 -
Empiric guideline-recommended weight-based vancomycin dosing and nephrotoxicity rates in patients with methicillin-resistant Staphylococcus aureus bacteremia: a retrospective cohort study
Previous studies have established a correlation between vancomycin troughs and nephrotoxicity. However, data are currently lacking regarding the effect of guideline-recommended weight-based dosing on nephrotox...
Citation: BMC Pharmacology and Toxicology 2013 14:12 -
3-D DNA methylation phenotypes correlate with cytotoxicity levels in prostate and liver cancer cell models
The spatial organization of the genome is being evaluated as a novel indicator of toxicity in conjunction with drug-induced global DNA hypomethylation and concurrent chromatin reorganization. 3D quantitative D...
Citation: BMC Pharmacology and Toxicology 2013 14:11 -
Inappropriate long-term use of antipsychotic drugs is common among people with dementia living in specialized care units
Antipsychotic drugs are widely used for the treatment of Behavioral and Psychological Symptoms of Dementia (BPSD), despite their limited efficacy and concerns about safety. The aim of this study was to describ...
Citation: BMC Pharmacology and Toxicology 2013 14:10 -
Effects of early life exposure to ultraviolet C radiation on mitochondrial DNA content, transcription, ATP production, and oxygen consumption in developing Caenorhabditis elegans
Mitochondrial DNA (mtDNA) is present in multiple copies per cell and undergoes dramatic amplification during development. The impacts of mtDNA damage incurred early in development are not well understood, espe...
Citation: BMC Pharmacology and Toxicology 2013 14:9 -
Unusual case of severe arrhythmia developed after acute intoxication with tosylchloramide
Drugs not commonly considered to be cardioactive agents may cause prolongation of the QT interval with resultant torsades de pointes and ventricular fibrillation. This form of drug toxicity often causes cardia...
Citation: BMC Pharmacology and Toxicology 2013 14:8 -
Vascular disrupting agent for neovascular age related macular degeneration: a pilot study of the safety and efficacy of intravenous combretastatin a-4 phosphate
This study was designed to assess the safety, tolerability, and efficacy of intravenous infusion of CA4P in patients with neovascular age-related macular degeneration (AMD).
Citation: BMC Pharmacology and Toxicology 2013 14:7 -
Glibenclamide inhibits cell growth by inducing G0/G1 arrest in the human breast cancer cell line MDA-MB-231
Glibenclamide (Gli) binds to the sulphonylurea receptor (SUR) that is a regulatory subunit of ATP-sensitive potassium channels (KATP channels). Binding of Gli to SUR produces the closure of KATP channels and the ...
Citation: BMC Pharmacology and Toxicology 2013 14:6 -
Adverse drug reaction monitoring: support for pharmacovigilance at a tertiary care hospital in Northern Brazil
Adverse drug reactions (ADRs) are recognised as a common cause of hospital admissions, and they constitute a significant economic burden for hospitals. Hospital-based ADR monitoring and reporting programmes ai...
Citation: BMC Pharmacology and Toxicology 2013 14:5 -
Allosteric transition: a comparison of two models
Two recent models are in use for analysis of allosteric drug action at receptor sites remote from orthosteric binding sites. One is an allosteric two-state mechanical model derived in 2000 by David Hall. The o...
Citation: BMC Pharmacology and Toxicology 2013 14:4 -
Hit identification of IKKβ natural product inhibitor
The nuclear factor-κB (NF-κB) proteins are a small group of heterodimeric transcription factors that play an important role in regulating the inflammatory, immune, and apoptotic responses. NF-κB activity is su...
Citation: BMC Pharmacology and Toxicology 2013 14:3 -
Electrophysiological and pharmacological evaluation of the nicotinic cholinergic system in chagasic rats
Two theories attempt to explain the changes observed in the nicotinic acetylcholine receptors (nAChRs) in chagasic cardiomyopathy. The neurogenic theory proposes that receptor changes are due to loss of intrac...
Citation: BMC Pharmacology and Toxicology 2013 14:2 -
A review of the differences and similarities between generic drugs and their originator counterparts, including economic benefits associated with usage of generic medicines, using Ireland as a case study
Generic medicines are those where patent protection has expired, and which may be produced by manufacturers other than the innovator company. Use of generic medicines has been increasing in recent years, prima...
Citation: BMC Pharmacology and Toxicology 2013 14:1 -
Pharmacokinetic and pharmacodynamic characterization of a new formulation containing synergistic proportions of interferons alpha-2b and gamma (HeberPAG®) in patients with mycosis fungoides: an open-label trial
The synergistic combination of interferon (IFN) alpha-2b and IFN gamma results in more potent in vitro biological effects mediated by both IFNs. The aim of this investigation was to evaluate by first time the pha...
Citation: BMC Pharmacology and Toxicology 2012 13:20 -
Experiences from consumer reports on psychiatric adverse drug reactions with antidepressant medication: a qualitative study of reports to a consumer association
The new European pharmacovigilance legislation has been suggested as marking the beginning of a new chapter in drug safety, making patients an important part of pharmacovigilance. In Sweden since 2008 it has b...
Citation: BMC Pharmacology and Toxicology 2012 13:19 -
Efficacy of lisdexamfetamine dimesylate in adults with attention-deficit/hyperactivity disorder previously treated with amphetamines: analyses from a randomized, double-blind, multicenter, placebo-controlled titration study
To examine the efficacy of lisdexamfetamine dimesylate (LDX) in adults with attention-deficit/hyperactivity disorder (ADHD) who remained symptomatic (ADHD Rating Scale IV [ADHD-RS-IV] total score >18) on amphe...
Citation: BMC Pharmacology and Toxicology 2012 13:18
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