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- Open Access
The role of VASP in cGMP-mediated vascular smooth muscle relaxation
© Hildebrand et al; licensee BioMed Central Ltd. 2013
- Published: 29 August 2013
- Nitric Oxide
- Vascular Smooth Muscle Cell
- Small GTPase
- Guanylyl Cyclase
- Brown Adipocyte
Cyclic GMP (cGMP) is a major mediator of relaxation in the vascular system. cGMP is produced by the enzyme soluble Guanylyl Cyclase (sGC) in response to nitric oxide (NO) released from neighbouring endothelial cells. cGMP activates Protein Kinase G (PKG), which in turn mediates vascular relaxation through phosophorylation of various targets. One of the major substrates of PKG is the VAsodilator-Stimulated Phosphoprotein (VASP). The role of VASP in vascular smooth muscle relaxation is currently unknown. However, recent studies show that VASP-deficient brown adipocytes have an increased activity of the small GTPase Rac1 and elevated levels of sGC . These data suggest a regulatory role for VASP in cGMP-mediated processes.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.