The role of particulate guanylyl cyclase B (GC-B) in auditory function in adult mice
© Wolter et al. 2015
Published: 2 September 2015
cGMP signaling triggered by the binding of C-type natriuretic peptide (CNP) to its receptor guanylyl cyclase B (GC-B; NPR2; NPRB) has been linked by genetic evidence to a remarkable variety of physiological functions like skeletal bone growth, female fertility, cardiac growth, fat metabolism and gastrointestinal function. For the nervous system it has been recently demonstrated that the CNP/GC-B/cGMP/cGMP-dependent protein kinase type I (cGKI) signaling pathway is essential for sensory axon branching at the dorsal root entry zone of the spinal cord and at the rhombomeres of the hindbrain during embryonic development . Also in the auditory system, distinct auditory nerve fiber (ANF) types that differ in their discharge rate and sound sensitivity bifurcate in the cochlear nucleus (CN), sending collaterals to the anteroventral, posteroventral, and dorsal subdivisions. The lack of GC-B has been shown to lead to a central phenotype .
Here, we describe that the lack of GC-B in addition leads to a peripheral phenotype which is manifested in auditory threshold loss and altered wave amplitudes and latencies of stimulus-evoked auditory brainstem responses (ABR). Our preliminary results indicate that this deficit is related to a combined afferent and efferent fiber phenotype.
This work was supported by grants from the Deutsche Forschungsgemeinschaft (FOR 2060 project FE 438/5-1).
- Ter-Avetisyan G, Rathjen FG, Schmidt H: Bifurcation of axons from cranial sensory neurons is disabled in the absence of Npr2-induced cGMP signaling. J Neurosci. 2014, 34 (3): 737-747. 10.1523/JNEUROSCI.4183-13.2014.View ArticlePubMedGoogle Scholar
- Lu CC, Cao XJ, Wright S, Ma L, Oertel D, Goodrich LV: Mutation of Npr2 leads to blurred tonotopic organization of central auditory circuits in mice. PLoS Genet. 2014, 10 (12): e1004823-10.1371/journal.pgen.1004823.View ArticlePubMedPubMed CentralGoogle Scholar
- Sergeyenko Y, Lall K, Liberman MC, Kujawa SG: Age-related cochlear synaptopathy: an early-onset contributor to auditory functional decline. J Neurosci. 2013, 33 (34): 13686-13694. 10.1523/JNEUROSCI.1783-13.2013.View ArticlePubMedPubMed CentralGoogle Scholar
- Knipper M, Van Dijk P, Nunes I, Rüttiger I, Zimmermann U: Advances in the neurobiology of hearing disorders: recent developments regarding the basis of tinnitus and hyperacusis. Prog Neurobiol. 2013, 111: 17-33.View ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.