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The role of particulate guanylyl cyclase B (GC-B) in auditory function in adult mice
BMC Pharmacology and Toxicology volume 16, Article number: A102 (2015)
cGMP signaling triggered by the binding of C-type natriuretic peptide (CNP) to its receptor guanylyl cyclase B (GC-B; NPR2; NPRB) has been linked by genetic evidence to a remarkable variety of physiological functions like skeletal bone growth, female fertility, cardiac growth, fat metabolism and gastrointestinal function. For the nervous system it has been recently demonstrated that the CNP/GC-B/cGMP/cGMP-dependent protein kinase type I (cGKI) signaling pathway is essential for sensory axon branching at the dorsal root entry zone of the spinal cord and at the rhombomeres of the hindbrain during embryonic development . Also in the auditory system, distinct auditory nerve fiber (ANF) types that differ in their discharge rate and sound sensitivity bifurcate in the cochlear nucleus (CN), sending collaterals to the anteroventral, posteroventral, and dorsal subdivisions. The lack of GC-B has been shown to lead to a central phenotype .
Here, we describe that the lack of GC-B in addition leads to a peripheral phenotype which is manifested in auditory threshold loss and altered wave amplitudes and latencies of stimulus-evoked auditory brainstem responses (ABR). Our preliminary results indicate that this deficit is related to a combined afferent and efferent fiber phenotype.
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This work was supported by grants from the Deutsche Forschungsgemeinschaft (FOR 2060 project FE 438/5-1).
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Wolter, S., Möhrle, D., Zelle, D. et al. The role of particulate guanylyl cyclase B (GC-B) in auditory function in adult mice. BMC Pharmacol Toxicol 16, A102 (2015). https://doi.org/10.1186/2050-6511-16-S1-A102
- Auditory Brainstem Response
- Cochlear Nucleus
- Guanylyl Cyclase
- Auditory Nerve Fiber
- Root Entry Zone