Volume 16 Supplement 1

Abstracts from the 7th International Conference on cGMP Generators, Effectors and Therapeutic Implications

Meeting abstracts

Edited by Johannes-Peter Stasch, John Burnett, Harald Schmidt, Michaela Kuhn and Franz Hofmann

Publication of this supplement has been fully funded by FEBGLA e.V. Johannes-Peter Stasch is an employee of Bayer Pharma AG, Wuppertal, Germany. He holds many patents on sGC stimulators and sGC activators. John C Burnett Jr is the chairman of the advisory board for Nile Therapeutics and is a Co-Founder and the Chief Scientific Officer for Zumbro Discovery. Mayo Clinic has licensed CD-NP to Nile Therapeutics and MANP to Zumbro Discovery. The other Supplement Editors declare that they have no competing interests.

7th International Conference on cGMP Generators, Effectors and Therapeutic Implications. Go to conference site.

Trier, Germany19-21 June 2015

Concatenated PDF V16 S1

Page 1 of 3

LCZ696 (sacubitril/valsartan), an angiotensin receptor neprilysin inhibitor (ARNI): clinical development in heart failure

Authors: Martin P Lefkowitz

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A1

Content type: Meeting abstract Published on: 2 September 2015
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The clinical development of sGC modulators, riociguat and vericiguat

Authors: Frank Misselwitz

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A2

Content type: Meeting abstract Published on: 2 September 2015
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MANP: a novel particulate guanylyl cyclase A receptor/cGMP activator for resistant hypertension: preliminary first in human clinical trial results

Authors: John C Burnett Jr, Paul McKie, Denise Heublein, Brenda Huntley, Horng Chen, Valentina Cannone, Alessia Buglioni and Daniel McCormick

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A3

Content type: Meeting abstract Published on: 2 September 2015
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A soluble guanylate cyclase activator protects from diabetic nephropathy beyond standard of care in the ZSF1 rat

Authors: Steven S Pullen, Kathleen A Lincoln, Paul C Harrison, Hongxing Chen, Hong Wang, Holly Clifford, HuSheng Qian, Diane Wong, Chris Sarko, Jehrod Brenneman, Ryan Fryer, Jeremy Richman, Glenn A Reinhart and Carine Boustany

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A4

Content type: Meeting abstract Published on: 2 September 2015
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The discovery and characterization of novel soluble guanylate cyclase stimulators

Authors: Jaime L Masferrer

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A5

Content type: Meeting abstract Published on: 2 September 2015
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Stimulation of soluble guanylyl cyclase protects against obesity by recruiting brown adipose tissue

Authors: Alexander Pfeifer, Jennifer Etzrodt and Linda S Hoffmann

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A6

Content type: Meeting abstract Published on: 2 September 2015
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Natriuretic peptides and cGMP in metabolic disease

Authors: Sheila Collins

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A7

Content type: Meeting abstract Published on: 2 September 2015
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Soluble guanylyl cyclase regulates skeletal muscle fiber type plasticity, fatigue resistance and whole body insulin resistance

Authors: Younghye Moon, Jordan Balke, Michael Siegel, Peter Brouckaert, Emmanuel S Buys, David Marcinek and Justin Percival

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A8

Content type: Meeting abstract Published on: 2 September 2015
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Gene therapy approaches to restore retinal cGMP channel function

Authors: Martin Biel

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A9

Content type: Meeting abstract Published on: 2 September 2015
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NO/GMP as mediators of estrogen effects in bone

Authors: Hema Kalyanaraman, Jisha Joshua, Shunhui Zhuang, Esther Corey, Robert Sah and Renate B Pilz

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A10

Content type: Meeting abstract Published on: 2 September 2015
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Using PDE5 inhibitors for the prevention and treatment of colorectal cancer

Authors: Darren D Browning

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A11

Content type: Meeting abstract Published on: 2 September 2015
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cGMP and cardiac hypertrophy

Authors: Ruwan K Perera, Hariharan Subramanian, Alexander Froese, Daniela Hübscher, Konrad R Götz and Viacheslav O Nikolaev

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A12

Content type: Meeting abstract Published on: 2 September 2015
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Cyclic GMP/cGMP-dependent protein kinase type I signaling and cysteine-rich LIM-only protein 4 in AngII/AT₁R-induced heart hypertrophy and fibrosis

Authors: Robert Lukowski, Julia Straubinger and Peter Ruth

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A13

Content type: Meeting abstract Published on: 2 September 2015
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Roles of 8-nitro-cGMP in autophagy regulation

Authors: Hirokazu Arimoto

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A14

Content type: Meeting abstract Published on: 2 September 2015
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Structural basis of cyclic nucleotide selectivity in cGMP dependent protein kinase II

Authors: James C. Campbell, Kevin Y. Li, Jeong Joo Kim, Gilbert Huang, Albert S. Reger, Shinya Matsuda, Banumathi Sankaran, Todd M. Link, Keizo Yuasa, John E. Ladbury and Choel Kim

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A15

Content type: Meeting abstract Published on: 2 September 2015
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cGMP and cAMP pathways rearrange ARHGAP17 and ARHGEF6 protein complexes to control Rac1 in platelets

Authors: Zoltan Nagy, Kieran Wynne, Alexander von Kriegsheim, Stepan Gambaryan and Albert Smolenski

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A16

Content type: Meeting abstract Published on: 2 September 2015
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New insights into leveraging PKG signalling to treat diseased hearts

Authors: Dong ik Lee, Taishi Nakamura and David A. Kass

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A17

Content type: Meeting abstract Published on: 2 September 2015
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Targeting cyclic nucleotides in CNS drug discovery: a translational approach into cognition enhancement

Authors: Jos Prickaerts

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A18

Content type: Meeting abstract Published on: 2 September 2015
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Inhibition of cGMP-metabolizing PDEs as target for cognitive enhancement

Authors: Holger Rosenbrock

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A19

Content type: Meeting abstract Published on: 2 September 2015
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Ultrasensitive signal detection by a guanylyl cyclase chemoreceptor

Authors: U Benjamin Kaupp

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A20

Content type: Meeting abstract Published on: 2 September 2015
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Mechanism and protective properties of S-nitrosation by nitric oxide in cardiac mitochondria

Authors: Thomas Krieg

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A21

Content type: Meeting abstract Published on: 2 September 2015
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Novel roles of cardiac natriuretic peptides in renal compensatory hypertrophy

Authors: Andrea Schreiber, Janina Staffel, Daniela Valletta, Michaela Kuhn and Frank Schweda

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A22

Content type: Meeting abstract Published on: 2 September 2015
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Antifibrotic function of cGKI in the kidney

Authors: Jens Schlossmann, Elisabeth Schinner, Veronika Wetzll, Lothar Faerber and Franz Hofmann

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A23

Content type: Meeting abstract Published on: 2 September 2015
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Mixed linage kinase 3 functions as a cGMP-dependent protein kinase I alpha substrate and regulates blood pressure and cardiac remodeling in vivo

Authors: Timothy Calamaras, Robert Baumgartner, Guang-rong Wang, Roger Davis, Mark Aronovitz, David Kass, R Karas and Robert M Blanton

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A24

Content type: Meeting abstract Published on: 2 September 2015
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The cyclic nucleotide 3’,5’-cIMP produced by sGC is a second messenger in the vascular wall

Authors: Paul M Vanhoutte, Susan WS Leung and Yuansheng Gao

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A25

Content type: Meeting abstract Published on: 2 September 2015
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sGC redox regulation and asthma

Authors: Dennis J Stuehr, Arnab Ghosh, Cynthia J Koziol-White, Kewal Asosingh, Georgina Cheng, Lisa Ruple, Jennifer Rodgers, Dieter Groneberg, Andreas Friebe, Johannes-Peter Stasch, Reynold A Panettieri, Mark A Aronical and Serpil C Erzurum

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A26

Content type: Meeting abstract Published on: 2 September 2015
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Pivotal vascular homeostatic role for endothelium-derived C-type natriuretic peptide (CNP)

Authors: Adrian J Hobbs

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A27

Content type: Meeting abstract Published on: 2 September 2015
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Implication of C-type natriuretic peptide derived from vascular endothelial cells on blood pressure regulation

Authors: Kazuwa Nakao, Kazuhiro Nakao, Koichiro Kuwahara and Kenji Kangawa

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A28

Content type: Meeting abstract Published on: 2 September 2015
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Receptor guanylyl cyclase-G is a sensory protein activated by cool temperatures and predator odor 2,4,5-trimethylthiazoline

Authors: Ruey-Bing Yang

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A29

Content type: Meeting abstract Published on: 2 September 2015
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Dephosphorylation of juxtamembrane serines and threonines of the NPR2 guanylyl cyclase regulates oocyte meiotic resumption

Authors: Leia C Shuhaibar, Aaron B Edmund, Jeremy R Egbert, Siu-Pok Yee, Lincoln R Potter and Laurinda A Jaffe

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A30

Content type: Meeting abstract Published on: 2 September 2015
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Hormone suppression silencing GUCY2C is required for colorectal cancer

Authors: Scott A Waldman

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A31

Content type: Meeting abstract Published on: 2 September 2015
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Computational exploration of the binding mode of the heme-dependent activator YC-1 into the active catalytic site of soluble guanylate cyclase

Authors: Luis Agulló, Ignasi Buch, Hugo Gutiérrez de Terán, Gianni de Fabritis, David Garcia-Dorado and Jordi Villà-Freixa

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A32

Content type: Meeting abstract Published on: 2 September 2015
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Investigation of the role of multidrug resistance proteins (MRPs) in vascular homeostasis

Authors: Robert M H Allen, Aniruthan Renukanthan, Kristen J Bubb, Inmaculada C Villar, Amie J Moyes, Reshma S Baliga and Adrian J Hobbs

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A33

Content type: Meeting abstract Published on: 2 September 2015
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Construction of novel cGMP FRET-sensors based on PKG from Plasmodium falciparum

Authors: Gaia Calamera, Andrea Hembre Ulsund, Ornella Manfra, Jeong Joo Kim, Choel Kim, Finn Olav Levy and Kjetil Wessel Andressen

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A34

Content type: Meeting abstract Published on: 2 September 2015
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Anemia of cGKI deficient mice is caused by intestinal bleeding

Authors: Elisabeth Angermeier, Katrin Domes and Franz Hofmann

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A35

Content type: Meeting abstract Published on: 2 September 2015
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A case of chaos? NO causes arrhythmic motor pattern via interstitial cells of Cajal in the murine colon

Authors: Katharina Beck, Dieter Groneberg, Andreas Friebe and Barbara Lies

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A36

Content type: Meeting abstract Published on: 2 September 2015
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Circulating Atrial Natriuretic Peptide Genetic Association Study Identifies a Novel Gene Cluster Associated with Reduced NT-proANP, Increased Stroke and Higher Diastolic Blood Pressure

Authors: Naveen L Pereira, Nirubol Tosakulwong, Christopher G Scott, Gregory D Jenkins, Naresh Prodduturi, Yubo Chai, Timothy M Olson, Richard J Rodeheffer, Margaret M Redfield MD, Richard M Weinshilboum and John C Burnett Jr.

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A37

Content type: Meeting abstract Published on: 2 September 2015
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Inhaled Nitric Oxide: an sGC-dependent IOP lowering agent

Authors: Wolfgang S Lieb, Stefan Munster, Ana C Dordea, Sara Vandenwijngaert, Robert E Tainsh, Peter Brouckaert, Warren M Zapol and Emmanuel S Buys

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A38

Content type: Meeting abstract Published on: 2 September 2015
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A systems biology approach to cGMP suggests a prominent role for sGC in stroke: Validation by mechanism-based activation of apo-sGC in non-steal dosing coveys neuroprotection and increased survival

Authors: Ana I Casas, Friederike Langhauser, Vu Thao-Vi Dao, Emre Guney, Pamela WM Kleikers, Manuela García López, Jörg Menche, Albert-László Barabási, Christoph Kleinschnitz and Harald HHW Schmidt

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A39

Content type: Meeting abstract Published on: 2 September 2015
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The predator odor 2,4,5-trimethylthiazoline binds and activates receptor guanylyl cyclase-G to elicit innate defensive responses

Authors: Ying-Chi Chao and Ruey-Bing Yang

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A40

Content type: Meeting abstract Published on: 2 September 2015
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C-type natriuretic peptide prevents activation of perivascular mast cells and inflammation in the postischemic microvasculature

Authors: Wen Chen, Katharina Völker, Birgit Gaßner, Franziska Werner, Anja Rabenhorst, Karin Hartmann and Michaela Kuhn

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A41

Content type: Meeting abstract Published on: 2 September 2015
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Nitrosopersulfide (SSNO^-) targets soluble guanylyl cyclase and induces vasodilation in vivo

Authors: Miriam M Cortese-Krott, Gunter GC Kuhnle, Alex Dyson, Bernadette O Fernandez, Marian Grman, Mark P Barrow, George McLeod, Karol Ondrias, Péter Nagy, Mervyn Singer, Malte Kelm, Anthony R Butler and Martin Feelisch

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A42

Content type: Meeting abstract Published on: 2 September 2015
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Investigating the impact of a mutation in PDE5A on myocardial infarction

Authors: Tan A Dang, Jana Wobst, Thorsten Kessler, Simon V Ameln, Manuel Lehm, Matthias Prestel, Ingrid Braenne, Redouane Aherrahrou, Martin Dichgans, Christian Hengstenberg, Jeanette Erdmannn and Heribert Schunkert

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A43

Content type: Meeting abstract Published on: 2 September 2015
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Catalytically active guanylyl cyclase-B requires glycosylation and mutations that inhibit this process cause dwarfism

Authors: Deborah M Dickey, Aaron B Edmond, Thomas Chaffee and Lincoln R Potter

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A44

Content type: Meeting abstract Published on: 2 September 2015
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Zebrafish as model organism for cNMP research

Authors: Fanni Dittmar, Salim Seyfried, Volkhard Kaever and Roland Seifert

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A45

Content type: Meeting abstract Published on: 2 September 2015
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Arterial stiffness and collagen expression in mice lacking NO-sensitive guanylyl cyclase

Authors: Sarah Dünnes, Dieter Groneberg, Volker Herold, Peter Jakob and Andreas Friebe

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A46

Content type: Meeting abstract Published on: 2 September 2015
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Mutation of a conserved lysine in the kinase homology domain reduces the natriuretic peptide-dependent activity and phosphorylation of guanylyl cyclase-A

Authors: Aaron B Edmund and Lincoln R Potter

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A47

Content type: Meeting abstract Published on: 2 September 2015
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Design and directed evolution of genetically encoded cGMP sensors

Authors: Arne Fabritius and Oliver Griesbeck

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A48

Content type: Meeting abstract Published on: 2 September 2015
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A CNP-cGMP-cGKI-MAPK pathway promotes melanoma growth in vitro and in vivo in mice

Authors: Sandeep Dhayade, Susanne Feil, Anja Ulmer, Susanne Kaesler, Tobias Sinnberg, Martin Thunemann, Ulrike Naumann, Tilo Biedermann, Birgit Schittek and Robert Feil

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A49

Content type: Meeting abstract Published on: 2 September 2015
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Cyclic GMP signaling and mitochondrial BK channels in cardioprotection against ischemia/reperfusion injury

Authors: Sandra Frankenreiter, Angelina Kniess, Peter Ruth, Thomas Krieg, Andreas Friebe and Robert Lukowski

Citation: BMC Pharmacology and Toxicology 2015 16(Suppl 1):A50

Content type: Meeting abstract Published on: 2 September 2015
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Abstracts from the 7th International Conference on cGMP Generators, Effectors and Therapeutic Implications

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