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Drug-related problems and medication reviews among old people with dementia
BMC Pharmacology and Toxicologyvolume 18, Article number: 52 (2017)
Drug-related problems, including medication errors and adverse drug events, are common among old people. Due to, for example, greater susceptibility to side effects, people with dementia are even more at risk of drug-related problems. The objectives of this study were to assess the occurrence and character of drug-related problems found among old people with dementia or cognitive impairment.
Data from a randomized controlled clinical trial exploring the effects of a pharmacist intervention as part of a hospital ward team in patients 65 years and older with dementia or cognitive impairment were used. The study was conducted between 2012 and 2014 in the orthopedic and medicine wards in two hospitals located in Northern Sweden. Drug-related problems identified in this patient group were classified and described, and associations with different factors were investigated.
Clinical pharmacists identified at least one DRP in 66% (140/212) of participants in the intervention group, for a total of 310 DRPs. Ineffective drug/inappropriate drug and unnecessary drug therapy were the most common drug-related problems. Discontinuation of drug therapy was the most common action carried out. Drug-related problems were more common among people prescribed a larger number of drugs and among people with an earlier stroke.
Drug-related problems are common among people with dementia and cognitive impairment. Comprehensive medication reviews conducted by clinical pharmacists as part of a health care team might be important to prevent, identify and solve these problems.
The use of drugs is a cornerstone of the care of older people. However, drug treatment in this group of people entails a significant risk of adverse drug events. Drug-related problems (DRPs) such as adverse drug reactions (ADRs), interactions, and potentially inappropriate drug use are common, and cause up to 30% of hospitalizations among old people . Even more at risk are people with dementia or cognitive impairment, where 41% of hospital admissions have been judged as caused or partly caused by DRPs . Age-related impairment of organic functions combined with other problems specific to this patient group, such as greater susceptibility to side effects and noncompliance, probably contributes to the increased rate of hospitalization [3,4,5,6,7]. Appropriate prescribing among old people is a considerable challenge, and optimizing drug therapy for old people with dementia is even more complex.
Clinical pharmacy can be defined as “a health specialty, which describes the activities and services of the clinical pharmacist to develop and promote the rational and appropriate use of medicinal products and devices” . Clinical pharmacy can, for example, be an activity implemented in primary care or in a hospital setting, such as medication reconciliation or medication reviews . Inadequate transfer of information at transition points between levels of care contributes to medication discrepancies, and medication reconciliation is performed in order to avoid this . A medication review is a systematic evaluation of an individual patient’s medicine treatment. According to the Pharmaceutical Care Network Europe (PCNE), a medication review is defined as “an evaluation of a patient’s medicines with the aim of optimizing the outcomes of medicine therapy. This entails identifying the risks, detecting medication-related problems and suggesting solutions” .
Systematic reviews suggest that clinical pharmacist interventions can improve patient outcomes in both primary care or hospital settings across many countries; for example in the US, the clinical pharmacist’s role in the clinic has been established for several years [11, 12] In Sweden, studies concerning clinical pharmacy outcome have been few, and this has probably contributed to slower progress. However, in recent years, the number of clinical pharmacists working in hospital wards in Sweden has increased.
A recent study from Sweden showed that the addition of clinical pharmacists to the healthcare team did not reduce the risk of drug-related readmissions during a 180-days follow-up period, however, post-hoc and subgroup analyses indicated significant effects favouring the intervention . In this study, the clinical pharmacists conducted medication reconciliation, medication reviews and participated in ward rounds, where clinically relevant DRPs were discussed with the health care team. The clinical pharmacists identified at least one DRP in 66% (140/212) of participants in the intervention group, for a total of 310 DRPs.
The objectives of the present study were to further assess the occurrence and character of DRPs found in the study above, as well as to describe the work with medication reviews. Another objective was to investigate associated factors to DRPs in old people with dementia or cognitive impairment.
Subjects and settings
Data for this study was gathered from a randomized controlled study (RCT) investigating the impact of adding the competence of a clinical pharmacist to a health care team . Patients admitted to the acute internal medicine ward and to the orthopedic clinic at Umeå University Hospital, and patients from medicine wards at the County Hospital in Skellefteå were included. Both hospitals are located in Northern Sweden. Eligible patients were aged 65 years or older and had dementia or cognitive impairment. The patients were recruited between January 9, 2012 and December 02, 2014. In total, 460 patients, 65 years and older with dementia or cognitive impairment, were randomized to an intervention (230 persons) or control group (230 persons). In this study, only people in the intervention group were analyzed. The final sample was 212 persons (18 people died during index admission and were excluded).
Three clinical pharmacists, who were already part of the different ward teams at the time the study started, conducted the interventions. The additional service provided by the clinical pharmacists consisted of medication reconciliation, medication review, and participation in ward rounds.
A medication reconciliation was performed for all patients in order to find discrepancies between the medication chart at hospital admission, and what patients were actually taking (Table 1). However, uses of OTC drugs were not investigated in this study because the clinical pharmacists did not talk to the patients about their medications. A comprehensive medication review comprising aspects associated with the patient’s drug therapy was then performed by the clinical pharmacist (Table 1). The clinical pharmacists used all available data, including the medication list, list of laboratory results, medical record notes from primary care, as well as notes from earlier contacts with health care providers, to compile an extensive medication history. In addition, general data regarding age, gender, and patient history were collected. Clinical response to drug treatment was monitored throughout the hospital stay.
The clinical pharmacist participated in ward rounds, and clinically relevant DRPs were discussed with the health care team (physicians, nurses, enrolled nurses). Advice was given about drug selection, dosages, and possible monitoring needs. When a drug was considered inappropriate for some reason, alternative drugs were suggested. The attending physicians made the final decision concerning proposed changes to therapy. The acceptance or rejection of the pharmacist’s recommendation for changes in drug therapy was documented.
Classifications of DRPs
DRPs were classified according to a modified version of Cipolle et al.,  into seven subgroups: ADR, dosage too high, dosage too low, ineffective drug, needs additional drug therapy, unnecessary drug therapy and noncompliance. Inappropriate drugs were added to the category ineffective drugs and, additionally, three further categories were introduced: interactions (pharmacodynamic and pharmacokinetic), transition errors and monitoring need. These three extra categories were classified as ADRs in the main paper .
The DRPs were defined as follows:
ADR: Adequate doses resulting in adverse drug reactions were classified as ADR.
Dosage too high: If the prescribed dose was too high in relation to the patient’s renal function, liver function or age, this was classified as dosage too high.
Dosage too low: If the prescribed dose was less than recommended, this was classified as dosage too low.
Ineffective/inappropriate drug: Inappropriate drug use according to explicit Swedish criteria  and inappropriate drugs according to renal function or disease were classified as ineffective/inappropriate drug.
Needs additional drug therapy: If a patient was inadequately medicated, this was classified as needs additional drug therapy.
Unnecessary drug therapy: If a patient had an unnecessary drug therapy, this was classified as unnecessary drug therapy.
Noncompliance: A deviation from the prescribed medications because of a choice, non-comprehension or forgetfulness, was classified as noncompliance.
Interactions: A drug interaction was defined as the modification of one drug by concomitant administration of another drug, producing loss of therapeutic effect or too high therapeutic effect.
Transition errors: Discrepancies between the medication charts upon hospital admission as compared with what patients were actually taking
Monitoring need: Need for therapeutic drug monitoring, laboratory test.
Simple logistic regression analyses were conducted to investigate the association between DRPs and different factors extracted from the medical record. These factors were gender, age, number of medications, type of ward, type of living, Mini Mental State Examination (MMSE), creatinine clearance and the patients’ medical histories. A multiple logistic regression analysis was conducted including significant variables from the simple models.
Results are presented as odds ratios (ORs) with 95% confidence intervals (CIs). P-values < 0.05 were considered statistically significant. All analyses were conducted using the Statistical Package for the Social Sciences (SPSS) for Windows, Version 23.0.
Of the 212 people included in the study, 133 (62.7%) were women and the mean age was 83.1 ± 6.6 years. Alzheimer’s disease [64/212 (30.2%)] and vascular dementia [42/212 (19.8%)] were the most common dementia diagnoses. The remaining 106 people suffered from Lewy body dementia [5/212 (2.4%)], unspecified dementia, or cognitive impairment [101/212 (47.6%)], according to the medical record. Most patients [146/212 (68.9%)] lived at home.
Among the 310 DRPs identified by the clinical pharmacists in 66% (140/212) of the participants, ineffective drug/inappropriate drug (n = 54) and unnecessary drug therapy (n = 54) were the most common, followed by dosage too high (n = 44). Further DRPs were classified as ADR (n = 41), needs additional drug therapy (n = 37), transition error, (n = 26), interactions (n = 23), dosage too low (n = 14), monitoring need (n = 13) and noncompliance (n = 4) (Table 2).
More detailed examples of DRPs identified among these patients are listed in Table 3.
Suggested actions were carried out for 82%, where discontinuation of drug therapy was the most common (n = 78), followed by the category “other” which includes, for example, monitoring of laboratory values or correction of transition errors (n = 55). Other actions were reduction in dosage (n = 45), initiation of drug therapy (n = 21), change of drug (n = 19), increase in dosage (n = 8) and change of drug formulation (n = 4). Further, 24 suggestions were written in discharge notes, and 56 of the suggestions were rejected.
DRPs were more common among people taking a higher number of drugs (OR, 1.255 [95% CI, 1.137-1.385]) and among people with an earlier stroke (OR, 5.042 [95% CI, 2.032-12.509]). There were no significant differences between patients with and without DRPs regarding gender, living arrangement, or ward type (Table 4). In a multivariate model with DRP as the dependent variable and significant variables from the simple model as independent variables (number of drugs at admission, age [borderline significant], and stroke), the number of drugs (OR, 1.241 [95% CI, 1.122-1.374]) and stroke (OR, 4.306 [95% CI, 1.685-11.005]) remained significant.
The frequency of potential DRPs in old people with dementia or cognitive impairment was high in this study, which is in line with or slightly lower than in previous research performed among old people, though not specifically among people with dementia [16, 17]. Ineffective drug/inappropriate drug and unnecessary drug therapy were the most frequent DRPs. Discontinuation of drug therapy was the most common action carried out. DRPs were more common among people prescribed a larger number of drugs and among people with an earlier stroke.
To be able to conduct comprehensive medication reviews with good quality, the clinical pharmacists need full access to medical and laboratory records. In contrast to many other health care systems, in the county of Västerbotten, primary and hospital care use the same electronic medical record system making it possible to see data from medical record notes from different care settings which is needed to compile an extensive medication history. This is important, for example, to understand why a drug is prescribed from the beginning or to find out any earlier adverse effects. It also makes it possible to see patients’ drug lists from both primary care and hospital care which facilitates the potential of obtaining an accurate medication list, which is essential for assessing the patient’s medication treatment. However, discrepancies were still found in the present study, some of which could have resulted in patient harm; for example, there was an incorrect digoxin dosage prescribed at admission to the ward. Discrepancies in admission and discharge medications have also been found in previous research .
In a medication review, there are many aspects regarding drug therapy that need to be considered. Age-related changes in pharmacokinetics and pharmacodynamics in older people such as renal and liver impairment may increase the risk of side effects . Inappropriate drugs due to impaired renal function are prevalent among old people according to previous research,  as well as among old people with dementia or cognitive impairment . Examples of drugs prescribed inappropriately in patients with impaired renal function in the present study were oral antidiabetics such as metformin and glibenclamide. Among dosage too high, gabapentin and allopurinol were examples of drugs not dose-adjusted to the patients’ renal function. Clomethiazole was inappropriately prescribed for a patient with liver impairment, which could increase the bioavailability of clomethiazole significantly, leading to hypotension and falls . Contraindications, allergies, and swallowing problems are other potential drug-related problems that need to be identified in order to prevent inappropriate prescriptions.
It is important to pay attention to drugs known to cause problems for patients. Belonging to this group are, for example, drugs with a narrow therapeutic index, such as digoxin and lithium, or drugs that might give serious adverse reactions, such as warfarin or methotrexate. Potentially inappropriate drugs according to guidelines  should also be identified in a medication review, since these drugs have been associated with hospitalizations and higher mortality [2, 23]. Still, inappropriate drugs are prevalent among old people with dementia, and are probably prescribed in many cases to treat behavioral and psychological symptoms despite known side effects and limited effect . According to the Swedish National Board of Health and Welfare,  potentially inappropriate drugs found in the present study were, for example, long-acting benzodiazepines, antipsychotics and anticholinergic drugs. Additionally, another drug class belonging to potentially inappropriate drugs, non-steroidal anti-inflammatory drugs (NSAIDs), was prevalent among some of the patients in spite of concomitant heart failure and renal failure, which is surprising. It is well known that old people are at high risk of developing side effects from NSAIDs, such as gastrointestinal bleeding and renal toxicity, and that NSAIDs also increase the risk of hypertension and heart failure [25, 26].
Further, drug-drug interactions and interactions between drugs and herbal medicinal products are important to consider, since these can lead to adverse drug events and can be the reason for hospital admissions [2, 27]. In primary care, as well as today in the hospital care setting in Västerbotten County, prescribers have access to an interaction module in the electronic medical record system that is intended to identify and prevent important interactions. Nevertheless, important interactions were found that had not been acted upon such as, for example, interactions caused by drugs containing di- and trivalent cations such as calcium, magnesium and iron. Antibiotics like ciprofloxacin and doxycycline, as well as levothyroxine and bisphosphonates, are drugs whose absorption is reduced by these cations if administered simultaneously per os [28,29,30].
Many DRPs were classified as “needs additional drug therapy.” One of the most common DRPs in this group was people with opioids prescribed without concomitant laxatives and under-prescription of drugs for heart failure. Untreated conditions and under-prescriptions of beneficial medicines in older people are important to identify, probably even more important among people with dementia, since executive dysfunction may lead to difficulties in identifying, recognizing, and reporting adverse drug events. A side effect that may be relatively easy to handle normally, such as constipation, may become a major problem in patients with dementia, possibly leading to hospitalization if recognition is delayed.
Whether the indication for a therapy still exists is also an important factor to investigate when performing a medication review in order to avoid unnecessary drug events. There might be several reasons, but mechanistic renewal of prescriptions is probably one reason for why people have the same medications for prolonged times. Antihypertensive medications, oral iron formulations and antihistamines without current indication are examples from the present study.
Noncompliance accounted for only 4/310 (1.3%) of the DRPs found in this study, a number that is probably greatly underestimated. Because the patients suffered from dementia or cognitive impairment, the clinical pharmacists did not talk to them and, therefore, could not assess compliance. Even a small degree of cognitive impairment may have major negative impact on compliance with drug therapy among the healthy elderly,  and this can, for example, mean that the patients might be unable to use inhaler devices properly, leading to ineffective drug treatment. In addition, uses of OTC drugs were not investigated in this study. Many existing DRPs were probably not discovered in the present study.
DRPs were more common among people prescribed a larger number of drugs in this study. A larger number of drugs have also been associated with an increased risk of hospitalization among people with dementia and cognitive impairment . However, it is also important to evaluate drug lists with only a few drugs. In one study, pharmacist intervention appeared to be more effective in preventing visits to the ED in patients taking <5 drugs on admission than in those taking ≥5 drugs .
DRPs were also more common among people with an earlier stroke. The reason for this could possibly be due to the use of secondary preventive drugs among this group of people such as antiplatelet agents, anticoagulant and hypertensive drugs. In previous studies, cardiovascular drugs have been associated with adverse drug events such as hypotension and electrolyte disturbances, and antiplatelet and anticoagulant drugs with haemorrhage,  which likewise was the case in the present study. However, a lack of secondary preventive drugs among people with a previous stroke also gave rise to potential DRPs discussed with the ward team in the present study.
The most common action taken for the clinical pharmacists’ suggestions was discontinuation of drug therapy. Another action was reduction in dosage due to, for example, impaired renal function. Suggestions were only rejected in 18% of the cases; hence, the acceptance rate was high. This is probably due to the fact that clinical pharmacists were already part of and accepted by the ward team at the start of the study. In addition, adequate training in clinical pharmacy and experience are important factors for being prepared to meet the specific challenges of clinical pharmacy work in primary care and in hospital care.
Some limitations of this study have to be taken into account. Since the clinical pharmacists did not talk to the patients, it could not be assessed whether the medications were actually taken by the patient. In addition, uses of OTC drugs were not investigated in this study. Further, whether the DRPs identified by the clinical pharmacists were clinically relevant and significant was not evaluated. However, based on the high acceptance rate (82%), it is reasonable to assume that most of the DRPs were judged to be clinically relevant by the physician in charge.
Drug-related problems are common among people with dementia and cognitive impairment. Comprehensive medication reviews conducted by clinical pharmacists as part of a health care team might be important for preventing, identifying and solving these problems.
Adverse drug reaction
Drug related problem
Mini Mental State Examination
Non-steroidal anti-inflammatory drugs
Pharmaceutical Care Network Europe
Randomized controlled study
Statistical package for the social science
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This study was supported financially by grants from the Swedish Dementia Association, the County Council of Västerbotten, Janne Elgqvists foundation and the Swedish Society of Medicine.
Availability of data and materials
Confidentiality agreements prevent us from sharing the raw interview data.
BP, JJ and MG conceived the study. All authors were involved in study design. MG undertook data analysis and was responsible for interpretation. All authors contributed to the writing of the manuscript. All authors read and approved the final manuscript.
The authors declare that they have no competing interests.
Consent for publication
Ethics approval and consent to participate
In accordance with the Ethical Review Law applicable in Sweden, permission was sought and approved for research without consent (registration number 2011-148-31 M). Written and orally presented information was provided to both participants and relatives, and patients who did not wish to participate were able to decline or withdraw from the study.
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