Articles
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Citation: BMC Pharmacology and Toxicology 2021 22:37
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In-silico evaluation of Malawi essential medicines and reactive metabolites for potential drug-induced toxicities
Drug-induced toxicity is one of the problems that have negatively impacted on the well-being of populations throughout the world, including Malawi. It results in unnecessary hospitalizations, retarding the dev...
Citation: BMC Pharmacology and Toxicology 2021 22:36 -
Effect of perioperative use of parecoxib on chronic post-surgical pain in elderly patients after hepatectomy: a prospective randomized controlled study
Chronic post-surgical pain (CPSP) has a negative impact on the recovery, quality of life, and physical functioning of elderly patients. This study aimed to test the superiority of parecoxib vs. placebo in prev...
Citation: BMC Pharmacology and Toxicology 2021 22:35 -
Assessment of safety and tolerability of remogliflozin etabonate (GSK189075) when administered with total daily dose of 2000 mg of metformin
Patients with type 2 diabetes mellitus (T2DM) are characterized by an elevated glycemic index and are at a higher risk for complications such as cardiovascular disease, nephropathy, retinopathy and peripheral ...
Citation: BMC Pharmacology and Toxicology 2021 22:34 -
Allisartan ameliorates vascular remodeling through regulation of voltage-gated potassium channels in hypertensive rats
The objective of the present study was to determine the effect of allisartan, a new angiotensin II type 1 receptor antagonist on vascular remodeling through voltage gated potassium channels (Kv7) in hypertensi...
Citation: BMC Pharmacology and Toxicology 2021 22:33 -
Molecular typing, biofilm production, and detection of carbapenemase genes in multidrug-resistant Acinetobacter baumannii isolated from different infection sites using ERIC-PCR in Hamadan, west of Iran
Acinetobacter baumannii is an opportunistic pathogen that can cause several kinds of nosocomial infections. Increasing antibiotic resistance as well as identifying genetic diversity and factors associated with pa...
Citation: BMC Pharmacology and Toxicology 2021 22:32 -
Protective effect of alamandine on doxorubicin‑induced nephrotoxicity in rats
This study aimed to evaluate the protective effects of alamandine, a new member of the angiotensin family, against doxorubicin (DOX)-induced nephrotoxicity in rats.
Citation: BMC Pharmacology and Toxicology 2021 22:31 -
Association between phosphate disturbances and mortality among critically ill patients with sepsis or septic shock
The aim of this study is to examine the association of hypophosphatemia and hyperphosphatemia on the first day of ICU admission with mortality in septic critically ill patients.
Citation: BMC Pharmacology and Toxicology 2021 22:30 -
Pharmacokinetic-pharmacodynamic modelling of atazanavir in hair among adolescents on antiretroviral treatment in Zimbabwe
Drug potency is a pharmacological parameter defining dose or concentration of drug required to obtain 50% of the drug’s maximal effect. Pharmacokinetic-pharmacodynamic modelling and simulation allows estimatio...
Citation: BMC Pharmacology and Toxicology 2021 22:29 -
Gambogic acid protects LPS-induced apoptosis and inflammation in a cell model of neonatal pneumonia through the regulation of TrkA/Akt signaling pathway
In this work, we investigated the effects of gambogic acid (GA) on lipopolysaccharide (LPS)-induced apoptosis and inflammation in a cell model of neonatal pneumonia.
Citation: BMC Pharmacology and Toxicology 2021 22:28 -
Premedication with pioglitazone prevents doxorubicin-induced left ventricular dysfunction in mice
Doxorubicin (DOX) is widely used as an effective chemotherapeutic agent for cancers; however, DOX induces cardiac toxicity, called DOX-induced cardiomyopathy. Although DOX-induced cardiomyopathy is known to be...
Citation: BMC Pharmacology and Toxicology 2021 22:27 -
Establishment of a population pharmacokinetics model of vancomycin in 94 infants with septicemia and its application in individualized therapy
We aim to develop a population pharmacokinetics (PopPK) model of vancomycin for the treatment of septicemia in infants younger than one year. Factors influence of the PK was investigated to optimize vancomycin...
Citation: BMC Pharmacology and Toxicology 2021 22:26 -
Epidemiology, clinical presentation, treatment, and follow‐up of chronic mercury poisoning in China: a retrospective analysis
There are no reports on the incidence of chronic mercury poisoning in a large population in China. This study investigated the epidemiology, clinical manifestations, treatment, and follow-up of Chinese patient...
Citation: BMC Pharmacology and Toxicology 2021 22:25 -
The effective interplay of (non-) selective NSAIDs with neostigmine in animal models of analgesia and inflammation
Surgical procedures cause perioperative immunosuppression and neuroendocrine stress, exerted by activation of the autonomic nervous system and the hypothalamic-pituitary-adrenal axis. The acetylcholinesterase ...
Citation: BMC Pharmacology and Toxicology 2021 22:24 -
Transcriptome investigation of anti‐inflammation and immuno‐regulation mechanism of taurochenodeoxycholic acid
Taurochenodeoxycholic acid (TCDCA) is one of the major active components in bile acid. It was proven to have inhibitory activities on inflammation and also participate in host immuno-regulation. TCDCA exerts a...
Citation: BMC Pharmacology and Toxicology 2021 22:23 -
High-fat diet accelerate hepatic fatty acids synthesis in offspring male rats induced by perinatal exposure to nonylphenol
Low dose of NP exposure can alter adipose tissue formation, and the intake of high-fat diet (HFD) can also lead to the fatty liver disease. We investigated the combined effect of NP and HFD on the first offspr...
Citation: BMC Pharmacology and Toxicology 2021 22:22 -
Subacute poisoning with bifenthrin increases the level of interleukin 1ß in mice kidneys and livers
Bifenthrin is a pyrethroid. Chronic exposure of humans to the pesticide occurs. Reports about immunotoxicity and proinflammatory effect of pyrethroids were published. The aim of the article was to check if sub...
Citation: BMC Pharmacology and Toxicology 2021 22:21 -
Opportunities for successful de-escalation of proton pump inhibitors at a federally qualified health center
A Proton Pump Inhibitor (PPI) de-escalation initiative was piloted at a Family Medicine Federally Qualified Health Center (FQHC) after a needs assessment showed that PPIs were prescribed inappropriately. The o...
Citation: BMC Pharmacology and Toxicology 2021 22:20 -
Coenzyme Q10 protected against arsenite and enhanced the capacity of 2,3-dimercaptosuccinic acid to ameliorate arsenite-induced toxicity in mice
Arsenic poisoning affects millions of people. The inorganic forms of arsenic are more toxic. Treatment for arsenic poisoning relies on chelation of extracellularly circulating arsenic molecules by 2,3-dimecapt...
Citation: BMC Pharmacology and Toxicology 2021 22:19 -
The efficacy of calcitriol treatment in non-alcoholic fatty liver patients with different genotypes of vitamin D receptor FokI polymorphism
Vitamin D deficiency is prevalent in patients with non-alcoholic fatty liver disease (NAFLD), but there are debates on the usefulness of vitamin D treatment. The interindividual variations in response may be d...
Citation: BMC Pharmacology and Toxicology 2021 22:18 -
Effect of oral isotretinoin on muscle strength in patients with acne vulgaris: a prospective controlled study
Musculoskeletal side effects related to isotretinoin are frequently reported. This study aimed to investigate the effect of oral isotretinoin treatment on muscle strength. Our second aim was to evaluate whethe...
Citation: BMC Pharmacology and Toxicology 2021 22:17 -
Preliminary study of the toxicity and radioprotective effects of zymosan in vitro and in vivo
This study aimed to confirm the cytotoxicity of zymosan in vitro and in vivo and determine the appropriate treatment time and the dose of zymosan.
Citation: BMC Pharmacology and Toxicology 2021 22:16 -
Bupivacaine inhibits a small conductance calcium‐activated potassium type 2 channel in human embryonic kidney 293 cells
Bupivacaine blocks many ion channels in the heart muscle, causing severe cardiotoxicity. Small-conductance calcium-activated potassium type 2 channels (SK2 channels) are widely distributed in the heart cells a...
Citation: BMC Pharmacology and Toxicology 2021 22:15 -
Impact of previous exposure to systemic corticosteroids on unfavorable outcome in patients hospitalized for COVID-19
The impact of prior exposure to systemic corticosteroids on COVID-19 severity in patients hospitalized for a SARS-CoV-2 pneumonia is not known. The present study was designed to answer to this question.
Citation: BMC Pharmacology and Toxicology 2021 22:14 -
Proposal of initial and maintenance dosing regimens with linezolid for renal impairment patients
Linezolid is administered as a fixed dose to all patients despite evidence of overexposure and thrombocytopenia in renal impairment. The aims of this study were to evaluate the risk of thrombocytopenia and the...
Citation: BMC Pharmacology and Toxicology 2021 22:13 -
Patient safety and public health concerns: poor dissolution rate of pioglitazone tablets obtained from China, Myanmar and internet sites
Poor quality medicines have serious implications for public health. The aim of this study was to explore the quality of the antidiabetic pioglitazone, using samples collected in China and Myanmar, and samples ...
Citation: BMC Pharmacology and Toxicology 2021 22:12 -
New onset diabetes mellitus and cardiovascular events in Korean patients with acute myocardial infarction receiving high-intensity statins
High-intensity statin therapy is typically used in patients with acute myocardial infarction (AMI) for secondary prevention. However, there have been consistent concerns regarding its association with diabetes...
Citation: BMC Pharmacology and Toxicology 2021 22:11 -
New ibuprofen derivatives with thiazolidine-4-one scaffold with improved pharmaco-toxicological profile
Aryl-propionic acid derivatives with ibuprofen as representative drug are very important for therapy, being recommended especially for anti-inflammatory and analgesic effects. On other hand 1,3-thiazolidine-4-...
Citation: BMC Pharmacology and Toxicology 2021 22:10 -
Safety of natural anthraquinone emodin: an assessment in mice
Emodin, a natural anthraquinone, has shown potential as an effective therapeutic agent in the treatment of many diseases including cancer. However, its clinical development is hindered by uncertainties surroun...
Citation: BMC Pharmacology and Toxicology 2021 22:9 -
Epigenetic immunomodulatory effect of eugenol and astaxanthin on doxorubicin cytotoxicity in hormonal positive breast Cancer cells
Hormonal receptor positive (HR+) breast cancer is the most commonly diagnosed molecular subtype of breast cancer; which showed good response to doxorubicin (DOX)-based chemotherapy. Eugenol (EUG) and astaxanth...
Citation: BMC Pharmacology and Toxicology 2021 22:8 -
Improved effect of a mitochondria-targeted antioxidant on hydrogen peroxide-induced oxidative stress in human retinal pigment epithelium cells
Oxidative damage to retinal pigment epithelial (RPE) cells contributes to the development of age-related macular degeneration, which is among the leading causes of visual loss in elderly people. In the present...
Citation: BMC Pharmacology and Toxicology 2021 22:7 -
Depressive effectiveness of vigabatrin (γ-vinyl-GABA), an antiepileptic drug, in intermediate-conductance calcium-activated potassium channels in human glioma cells
Vigabatrin (VGB) is an approved non-traditional antiepileptic drug that has been revealed to have potential for treating brain tumors; however, its effect on ionic channels in glioma cells remains largely uncl...
Citation: BMC Pharmacology and Toxicology 2021 22:6 -
Detecting medication errors associated with the use of beta-lactams in the Russian Pharmacovigilance database
Comprehensive analysis of all available data in spontaneous reports (SRs) can reveal previously unidentified medication errors (MEs).
Citation: BMC Pharmacology and Toxicology 2021 22:5 -
N-acetylcysteine dose-dependently improves the analgesic effect of acetaminophen on the rat hot plate test
Acetaminophen (APAP) induced hepatotoxicity is a clinically important problem. Up to now, interventive therapy with n-acetylcysteine (NAC) has been considered as a gold-standard treatment for APAP overdose. Ho...
Citation: BMC Pharmacology and Toxicology 2021 22:4 -
Extended adverse effects of cyclophosphamide on mouse ovarian function
Most patients with cancer undergo multiple administrations of anticancer drugs during treatment, resulting in chronic impairment of their reproductive health. As improved treatment options increase cancer surv...
Citation: BMC Pharmacology and Toxicology 2021 22:3 -
Comparative associations between anticholinergic burden and emergency department visits for anticholinergic adverse events in older Korean adults: a nested case-control study using national claims data for validation of a novel country-specific scale
Considering the limited generalizability of previous anticholinergic burden scales, the Korean Anticholinergic Burden Scale (KABS) as a scale specific to the Korean population was developed. We aimed to valida...
Citation: BMC Pharmacology and Toxicology 2021 22:2 -
Folic acid modified TPGS as a novel nano-micelle for delivery of nitidine chloride to improve apoptosis induction in Huh7 human hepatocellular carcinoma
The development of novel and effective drugs for targeted human hepatocellular carcinoma still remains a great challenge. The alkaloid nitidine chloride (NC), a component of a traditional Chinese medicine, has...
Citation: BMC Pharmacology and Toxicology 2021 22:1 -
Pharmacokinetic study of a novel oral formulation of S-adenosylmethionine (MSI-195) in healthy subjects: dose escalation, food effect and comparison to a commercial nutritional supplement product
A novel, high bioavailability oral, enteric coated tablet formulation of S-adenosylmethionine (MSI-195) has been developed for life science application. The present research reports on a Phase 1 study to (i) d...
Citation: BMC Pharmacology and Toxicology 2020 21:88 -
Common causes and characteristics of adverse drug reactions in older adults: a retrospective study
Aging populations are often accompanied by comorbidity and polypharmacy, leading to increases in adverse drug reactions (ADRs). We sought to evaluate the causes and characteristics of ADRs in older Korean adul...
Citation: BMC Pharmacology and Toxicology 2020 21:87 -
Efficacy and safety of bempedoic acid alone or combining with other lipid-lowering therapies in hypercholesterolemic patients: a meta-analysis of randomized controlled trials
Bempedoic acid is a new drug that reduces cholesterol synthesis via inhibiting ATP citrate lyase. It remains unclear whether the combination of bempedoic acid and other lipid-lowering drugs is better than thes...
Citation: BMC Pharmacology and Toxicology 2020 21:86 -
Lipopolysaccharide exposure induces oxidative damage in Caenorhabditis elegans: protective effects of carnosine
The present study was designed to investigate the protective effects and mechanisms of carnosine on lipopolysaccharide (LPS)-induced injury in Caenorhabditis elegans.
Citation: BMC Pharmacology and Toxicology 2020 21:85 -
Nebivolol combined with tetrahydrobiopterin affects diastolic function in spontaneously hypertensive rats via the nitric oxide/cyclic guanosine monophosphate signalling pathway
Hypertension is the the primary cause of diastolic heart failure. Oxidative stress plays an important role in cardiac diastolic dysfunction caused by hypertension. The occurrence of oxidative stress is related...
Citation: BMC Pharmacology and Toxicology 2020 21:84 -
Presentations of tetramethylammonium hydroxide dermal exposure and the valuable potential of diphoterine solution in decontamination: a retrospective observational study
Tetramethylammonium hydroxide (TMAH) is a quaternary ammonium compound that is both a base corrosive and a cholinergic agonist, and it is widely used in the photoelectric and semiconductor industries. It cause...
Citation: BMC Pharmacology and Toxicology 2020 21:83 -
Pharmacodynamic and pharmacokinetic behavior of landiolol during dobutamine challenge in healthy adults
To study the pharmacokinetic and -dynamic behavior of landiolol in the presence of dobutamine in healthy subjects of European ancestry.
Citation: BMC Pharmacology and Toxicology 2020 21:82 -
Attenuation of LPS-induced acute lung injury by continentalic acid in rodents through inhibition of inflammatory mediators correlates with increased Nrf2 protein expression
Acute lung injury (ALI) together with acute respiratory distress syndrome (ARDS) are associated with high rate of mortality and morbidity in patients. In the current study, the anti-inflammatory effects of con...
Citation: BMC Pharmacology and Toxicology 2020 21:81 -
Bioequivalence of levamlodipine besylate tablets in healthy Chinese subjects: a single-dose and two-period crossover randomized study
Levamlodipine, a calcium channel blocker, has been show act as a cardiovascular drug. To compare the pharmacokinetic parameters between levamlodipine (test formulation) at a single dose of 5 mg and amlodipine ...
Citation: BMC Pharmacology and Toxicology 2020 21:80 -
Two novel anticancer compounds with minimum cardiotoxic property
Although two novel synthesized compounds with tri-aryl structures; 3-(4-chlorophenyl)-5-(4-fluorophenyl)-4-phenyl-4,5-dihydro-1,2,4-oxadiazole (A) and 3,5-bis-(4-chlorophenyl)-4-phenyl-4,5-dihydro-1,2,4-oxadiazol...
Citation: BMC Pharmacology and Toxicology 2020 21:79 -
Bioprospecting the antimicrobial, antibiofilm and antiproliferative activity of Symplocos racemosa Roxb. Bark phytoconstituents along with their biosafety evaluation and detection of antimicrobial components by GC-MS
Plants provide a ray of hope to combat the ever increasing antibiotic resistance and Symplocos racemosa is a valuable medicinal plant. The study focused on highlighting the importance of this plant’s phytoconstit...
Citation: BMC Pharmacology and Toxicology 2020 21:78 -
The effect of grape seed and green tea extracts on the pharmacokinetics of imatinib and its main metabolite, N-desmethyl imatinib, in rats
Imatinib is mainly metabolized by CYP3A4 and to a lesser extent by other isoenzymes, with N-desmethyl imatinib being its major equipotent metabolite. Being a CYP3A4 substrate, imatinib co-administration with CYP3...
Citation: BMC Pharmacology and Toxicology 2020 21:77 -
A new anabolic compound, LLP2A-Ale, reserves periodontal bone loss in mice through augmentation of bone formation
Currently, there are no effective medications to reverse periodontal disease (PD)-induced bone loss. The objective of this study was to test a new anabolic compound, LLP2A-Ale, or with the combination treatmen...
Citation: BMC Pharmacology and Toxicology 2020 21:76
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