Articles

Antiepileptic activity and subtype-selective action of flupirtine at GABA_Areceptors

Authors: Mirnes Bajrić, Felicia Klinger, Ulla Schandl, Helmut Kubista and Stefan Boehm

Plasma nitrite concentrations decrease after hyperoxia-induced oxidative stress in healthy humans

Authors: Darko Modun, Mladen Krnić, Jonatan Vuković, Višnja Kokić, Lea Kukoč-Modun, Dimitrios Tsikas and Zeljko Dujić

Consumption of serum lipid-reducing drugs in Serbia compared with Scandinavian countries: a population-based study, 2004–2010

Authors: Ana Sabo, Zdenko Tomić, Nebojša Stilinović, Boris Milijašević, Momir Mikov, Saša Vukmirović and Olga Horvat

Axonal transport of botulinum toxin A from periphery to CNS in sensory and motor nerves

Authors: Ivica Matak, Lidija Bach-Rojecky, Boris Filipović, Peter Riederer and Zdravko Lacković

NKP-1339, a first-in-class anticancer drug showing mild side effects and activity in patients suffering from advanced refractory cancer

Authors: Robert Trondl, Petra Heffeter, Michael A Jakupec, Walter Berger and Bernhard K Keppler

Real-time uptake of fluorescent ASP+ via the organic cation transporter 3

Authors: Felix P Mayer, Diethart Schmid, Marion Holy, Jae-Won Yang, Isabella Salzer, Stefan Boehm, Peter Chiba and Harald H Sitte

The NBD-NBD interface is not the sole determinant for transport in ABC transporters

Authors: Yaprak Dönmez, Zahida Parveen, Peter Chiba and Thomas Stockner

ABC transporters of the liver fluke Fasciola hepatica

Authors: Oliver Kudlacek, Yaprak Dönmez and Thomas Stockner

Characterization of colistin tissue pharmacokinetics by microdialysis

Authors: Peter Matzneller, William Couet, Patrice Gobin, Markus Müller and Markus Zeitlinger

Therapeutic potential of a novel multifunctional iron chelator on cognitive decicits and insulin degrading enzyme expression in a rat model of sporadic Alzheimer's disease

Authors: Ana Knezović, Marina Knapić, Jelena Osmanović-Barilar, Silvia Mandel, Moussa Youdim, Peter Riederer and Melita Šalković-Petrišić

Pharmacochaperoning of the ER-retained A₁adenosine receptor

Authors: Justyna Kusek, Christian W Gruber, Christian Nanoff and Michael Freissmuth

Functional and physical interactions between P2Y receptors and ion channels

Authors: Hend Gafar, Giri K Chandaka and Stefan Boehm

Identifying forces that stabilize the oligomeric state of bacterial homologs of neurotransmitter transporters

Authors: Kumaresan Jayaraman, Azmat Sohail, Michael Freissmuth, Harald H Sitte and Thomas Stockner

Deciphering structural rearrangements during transport process in the bacterial transporter GltPh, homolog to mammalian glutamate transporter

Authors: SanthoshKannan Venkatesan, Azmat Sohail, Walter Sandtner, Thomas Stockner, Gerhard F Ecker and Harald H Sitte

How does the carboxyl terminus assist folding and ER export of the serotonin transporter?

Authors: Ali El-Kasaby, Florian Koban, Michael Freissmuth and Sonja Sucic

Decrypting structural and functional changes in LeuT_Aaat atomic level employing LRET

Authors: Azmat Sohail, Simon Bulling, Peggy Stolt-Bergner, Oliver Kudlacek, Gerhard F Ecker, Michael Freissmuth, Thomas Stockner, Harald H Sitte and Walter Sandtner

Statins reduce endogenous dolichol levels in the neuroblastoma cell line SH-SY5Y

Authors: Bihter Atil, Evelyn Sieczkowski and Martin Hohenegger

Regulation of Ca_V1.3 Ca²⁺channels in cochlear inner hair cells

Authors: Alexandra Pinggera, Niels Brandt, Gurjot Kaur, Jutta Engel and Jörg Striessnig

Environmental enrichment and visceral inflammation regulate stress-induced c-Fos and NPY expression within the dentate gyrus

Authors: Florian Reichmann, Evelin Painsipp and Peter Holzer

Dopamine transporter phosphorylation site threonine 53 regulates substrate reuptake and amphetamine-stimulated efflux

Authors: Jae-Won Yang, James D Foster, Amy E Moritz, Sathyavathi ChallaSivaKanaka, Margaret A Smith, Marion Holy, Kyle Wilebski, Roxanne A Vaughan and Harald H Sitte

Discovery and biological evaluation of a diphenethylamine derivative (HS665), a highly potent and selective κ opioid receptor agonist

Authors: Mariana Spetea, Ilona P Berzetei-Gurske, Elena Guerrieri, Jayapalreddy Mallareddy, Géza Tóth and Helmut Schmidhammer

Impaired L-type Ca²⁺ channel function in the dystrophic heart

Authors: Xaver Koenig, Xuan B Dang, Lena Rubi, Ágnes K Mike, Péter Lukács, René Cervenka, Vaibhavkumar S Gawali, Hannes Todt, Reginald E Bittner and Karlheinz Hilber

Adverse drug reactions and polypharmacy in cardiac patients

Authors: Snežana Mugoša, Zoran Todorović and Majda Šahman-Zaimović

Vascular bioactivation of nitroglycerin: reaction mechanism revealed by crystal structure of aldehyde dehydrogenase-2

Authors: Barbara S Lang, Antonius CF Gorren, Gustav Oberdorfer, M Verena Wenzl, Cristina M Furdui, Leslie B Poole, Bernd Mayer and Karl Gruber

Potentially inappropriate medication use in the elderly in Montenegro

Authors: Marta Rolevski, Berina Kučević, Gordana Boljević, Snežana Mugoša and Momir Mikov

The effect of chronic fluoxetine administration on anxiety-like behavior and expression of 5-HT-related proteins in rats with constitutively altered 5-HT homeostasis

Authors: Maja Kesić, Jasminka Štefulj, Gordana Mokrović and Lipa Čičin-Šain

Understanding subtype-selective allosteric modulation of GABA_Areceptors

Authors: Roshan Puthenkalam, Zdravko Varagić, Pantea Mirheydari, Werner Sieghart and Margot Ernst

The relaxation of non-pregnant rat myometrium by resveratrol with participation of the NO–cGMP pathway

Authors: Radmila B Novaković, Dragana D Protić, Nebojša V Radunović, Vladimir I Kanjuh and Ljiljana C Gojković-Bukarica

Nitric oxide signaling in adipose triglyceride lipase-deficient microvascular endothelial cells

Authors: Marion Mussbacher, Sarah Winkler, Günter Hämmerle, Rudolf Zechner, Bernd Mayer and Astrid Schrammel

The role of PGE₂ EP₄receptors in the regulation of endothelial barrier function

Authors: Nora Kampitsch, Viktória Kónya, Rufina Schuligoi and Ákos Heinemann

Role of perivascular adipose tissue in endothelial dysfunction of adipose triglyceride lipase-deficient mice

Authors: Karoline Pail, Sarah Winkler, Gerald Wölkart, Günter Hämmerle, Rudolf Zechner, Alois Lametschwandtner, Bernd Mayer and Astrid Schrammel

Alloxan-induced diabetes alters rat common carotid artery response to adenosine

Authors: Miroslav Radenković, Marko Stojanović, Radmila Janković, Mirko Topalović and Milica Stojiljković

Laropiprant attenuates EP₃and TP prostanoid receptor-mediated thrombus formation

Authors: Sonia Philipose, Viktória Kónya, Mirjana Lazarević, Lisa M Pasterk, Gunther Marsche, Sasa Frank, Bernhard A Peskar, Ákos Heinemann and Rufina Schuligoi

Acetaminophen changes paracellular transport activity through regulation of the tight junction protein in an intestinal barrier model

Authors: Mohammad R Lornejad-Schäfer, Christine Schäfer and Klaus R Schröder

Drug Information Unit, Medical Faculty of Novi Sad

Authors: Saša Vukmirović, Ana Sabo, Zdenko Tomić, Nebojša Stilinović, Aleksandar Rašković, Boris Milijašević and Olga Horvat

The GABA_Areceptor α2 subunit gene (GABRA2) is associated with alcohol-related behavior

Authors: Dubravka Švob Štrac, Gordana Nedić, Matea Nikolac, Korona Nenadić Šviglin, Dorotea Mück-Šeler and Nela Pivac

Use of ACE inhibitors in Serbia in 2010

Authors: Boris Milijašević, Zdenko Tomić, Ana Sabo, Aleksandar Rašković and Momir Mikov

Antidepressant-like effects of benzodiazepine site inverse agonists in the rat forced swim test

Authors: Janko Samardžić and Dragan I Obradović

Validation of a transparent decision model to rate drug interactions

Multiple databases provide ratings of drug-drug interactions. The ratings are often based on different criteria and lack background information on the decision making process. User acceptance of rating systems...

Authors: Elmira Far, Ivanka Curkovic, Kelly Byrne, Malgorzata Roos, Isabelle Egloff, Michael Dietrich, Wilhelm Kirch, Gerd-A Kullak-Ublick and Marco Egbring

Tox-Database.net: a curated resource for data describing chemical triggered in vitro cardiac ion channels inhibition

Drugs safety issues are now recognized as being factors generating the most reasons for drug withdrawals at various levels of development and at the post-approval stage. Among them cardiotoxicity remains the m...

Authors: Sebastian Polak, Barbara Wiśniowska, Anna Glinka and Miłosz Polak

Microneedle pretreatment enhances the percutaneous permeation of hydrophilic compounds with high melting points

Two commercially available microneedle rollers with a needle length of 200 μm and 300 μm were selected to examine the influence of microneedle pretreatment on the percutaneous permeation of four non-steroidal ...

Authors: Jessica Stahl, Mareike Wohlert and Manfred Kietzmann

Exploring the relationship between safety culture and reported dispensing errors in a large sample of Swedish community pharmacies

The potential for unsafe acts to result in harm to patients is constant risks to be managed in any health care delivery system including pharmacies. The number of reported errors is influenced by a various ele...

Authors: Annika Nordén-Hägg, Sofia Kälvemark-Sporrong and Åsa Kettis Lindblad

The potential for selective pharmacological therapies through biased receptor signaling

The discovery that not all agonists uniformly activate cellular signaling pathways (biased signaling) has greatly changed the drug discovery process for agonists and the strategy for treatment of disease with ...

Authors: Terry Kenakin

An interview with Philip Biggin, Section Editor for Computational, in silico and modelling studies

Authors: Philip C Biggin

Only connect: the merger of BMC Pharmacology and BMC Clinical Pharmacology

This editorial celebrates the launch of BMC Pharmacology and Toxicology within the BMC series of journals published by BioMed Central. The scope of the journal is interdisciplinary encompassing toxicology, experi...

Authors: Elizabeth C Moylan, Christopher Morrey and Joanne M Appleford-Cook