Skip to main content

Articles

Page 15 of 21

  1. Pyrogen detection is of utmost importance in pharmaceutical industry, laboratories and health care institutions. As an alternative to the animal-consuming rabbit pyrogen test or Limulus amoebocyte lysate test,...

    Authors: Christian Wunderlich, Stephan Schumacher and Manfred Kietzmann
    Citation: BMC Pharmacology and Toxicology 2014 15:50
  2. Lithium intoxication has potentially fatal neurologic and cardiac side effects. Extracorporeal removal can therefore be lifesaving. The dialysance of lithium is high as it is a small molecule. Comparable to it...

    Authors: Julius J Schmidt, Johan Lorenzen, Christos Chatzikyrkou, Ralf Lichtinghagen and Jan T Kielstein
    Citation: BMC Pharmacology and Toxicology 2014 15:49
  3. Higher versus lower doses of antiviral drugs used to treat herpes zoster infection may lead to more adverse drug events in older adults, particularly those with chronic kidney disease.

    Authors: Ngan N Lam, Jamie L Fleet, Eric McArthur, Peter G Blake and Amit X Garg
    Citation: BMC Pharmacology and Toxicology 2014 15:48
  4. Cardiotoxicity is a serious side effect to treatment with 5-fluorouracil (5-FU), but the underlying mechanisms are not fully understood. The objective of this systematic review was to evaluate the pathophysiol...

    Authors: Anne Polk, Kirsten Vistisen, Merete Vaage-Nilsen and Dorte L Nielsen
    Citation: BMC Pharmacology and Toxicology 2014 15:47
  5. In an effort to control non-medical use and/or medical abuse of prescription drugs, particularly prescription opioids, electronic prescription drug monitoring programs (PDMP) have been introduced in North-Amer...

    Authors: M Mofizul Islam and Ian S McRae
    Citation: BMC Pharmacology and Toxicology 2014 15:46
  6. This study compared palonosetron and ondansetron as rescue medications for postoperative nausea and vomiting (PONV) in patients who received prophylactic ondansetron. Although guidelines recommend use of an ag...

    Authors: Keith A Candiotti, Syed Raza Ahmed, David Cox and Tong J Gan
    Citation: BMC Pharmacology and Toxicology 2014 15:45
  7. Medicines to treat common colds (CC) and upper respiratory tract infections (URTI) are widely used among children, but there are only few data about treatments actually applied for these diseases. In the prese...

    Authors: Nathalie Eckel, Giselle Sarganas, Ingrid-Katharina Wolf and Hildtraud Knopf
    Citation: BMC Pharmacology and Toxicology 2014 15:44
  8. 11ß–hydroxysteroid dehydrogenase type1 (11β-HSD1) converts inactive glucocorticoids to active glucocorticoids which, in excess, leads to development of the various risk factors of the metabolic syndrome. Recen...

    Authors: Tharappel M Anil, Anilkumar Dandu, KrishnaReddy Harsha, Jaideep Singh, Nitya Shree, Venkatesh Satish Kumar, Mudigere N Lakshmi, Venkategowda Sunil, Chandrashekaran Harish, Gundalmandikal V Balamurali, Baisani S Naveen Kumar, Aralakuppe S Gopala, Shivakumar Pratibha, ManojKumar Sadasivuni, Mammen O Anup, Yoganand Moolemath…
    Citation: BMC Pharmacology and Toxicology 2014 15:43
  9. There are currently no serum biomarkers capable of distinguishing elevations in serum alanine aminotransferase (ALT) that portend serious liver injury potential from benign elevations such as those occurring d...

    Authors: Rohit Singhal, Alison H Harrill, Francoise Menguy-Vacheron, Zaid Jayyosi, Hadj Benzerdjeb and Paul B Watkins
    Citation: BMC Pharmacology and Toxicology 2014 15:42
  10. The genotoxic effect of cigarette smoke is routinely measured by treating cells with cigarette Particulate Matter (PM) at different dose levels in submerged cell cultures. However, PM exposure cannot be consid...

    Authors: Carolina Garcia-Canton, Graham Errington, Arturo Anadon and Clive Meredith
    Citation: BMC Pharmacology and Toxicology 2014 15:41
  11. Central disinhibition is a mechanism involved in the physiopathology of fibromyalgia. Melatonin can improve sleep quality, pain and pain threshold. We hypothesized that treatment with melatonin alone or in com...

    Authors: Simone Azevedo de Zanette, Rafael Vercelino, Gabriela Laste, Joanna Ripoll Rozisky, André Schwertner, Caroline Buzzatti Machado, Fernando Xavier, Izabel Cristina Custódio de Souza, Alicia Deitos, Iraci L S Torres and Wolnei Caumo
    Citation: BMC Pharmacology and Toxicology 2014 15:40
  12. Acetaminophen administration for more than 4 days causes aminotransferase elevation in some subjects. The objective of this randomized, placebo-controlled trial is to describe the course of alanine aminotransf...

    Authors: Kennon Heard, Jody L Green, Victoria Anderson, Becki Bucher-Bartelson and Richard C Dart
    Citation: BMC Pharmacology and Toxicology 2014 15:39
  13. The pharmacodynamic (PD) efficacy target of amoxicillin is 40% time above the minimal inhibition concentration (40%T > MIC). Recent studies of other antibiotics have shown that PD-efficacy targets are not alwa...

    Authors: Michiel Haeseker, Thomas Havenith, Leo Stolk, Cees Neef, Cathrien Bruggeman and Annelies Verbon
    Citation: BMC Pharmacology and Toxicology 2014 15:38
  14. The editors of BMC Pharmacology and Toxicology would like to thank all ourreviewers who have contributed to the journal in Volume 14 (2013).

    Authors: Helena C Flemyng
    Citation: BMC Pharmacology and Toxicology 2014 15:33
  15. Activation of peroxisome proliferator-activated receptor (PPAR)α and PPARδ causes an elevation of tissue carnitine concentrations through induction of genes involved in carnitine uptake [novel organic cation t...

    Authors: Aline Couturier, Robert Ringseis, Erika Most and Klaus Eder
    Citation: BMC Pharmacology and Toxicology 2014 15:37
  16. Analgesics are among the most commonly consumed drugs by the world populations. Within the broader context of self-medication, pain relief occupies a prominent position. Our study was to ascertain the prevalen...

    Authors: Pilar Carrasco-Garrido, Ana López de Andrés, Valentín Hernández Barrera, Isabel Jiménez-Trujillo, César Fernandez-de-las-Peñas, Domingo Palacios-Ceña, Soledad García-Gómez-Heras and Rodrigo Jiménez-García
    Citation: BMC Pharmacology and Toxicology 2014 15:36
  17. Glucocorticoids affect peripheral immune responses, including modulation of T-cell activation, differentiation, and apoptosis. The quantity and quality of T-cell receptor (TCR)-triggered intracellular signals ...

    Authors: Maria Grazia Petrillo, Katia Fettucciari, Paolo Montuschi, Simona Ronchetti, Luigi Cari, Graziella Migliorati, Emanuela Mazzon, Oxana Bereshchenko, Stefano Bruscoli, Giuseppe Nocentini and Carlo Riccardi
    Citation: BMC Pharmacology and Toxicology 2014 15:35
  18. Counterfeit and unapproved medicines are inherently dangerous and can cause patient injury due to ineffectiveness, chemical or biological contamination, or wrong dosage. Growth of the counterfeit medical marke...

    Authors: Dieter Pullirsch, Julie Bellemare, Andreas Hackl, Yvon-Louis Trottier, Andreas Mayrhofer, Heidemarie Schindl, Christine Taillon, Christian Gartner, Brigitte Hottowy, Gerhard Beck and Jacques Gagnon
    Citation: BMC Pharmacology and Toxicology 2014 15:34
  19. Patients on antiretroviral therapy have higher risk of developing adverse drug reactions (ADRs). The impact of ADRs on treatment adherence, treatment outcomes and future treatment options is quiet considerable...

    Authors: Wondmagegn Tamiru Tadesse, Alemayehu Berhane Mekonnen, Wubshet Hailu Tesfaye and Yidnekachew Tamiru Tadesse
    Citation: BMC Pharmacology and Toxicology 2014 15:32
  20. A few cases of adverse reactions linked to erroneous use of transdermal opioid patches have been reported in the literature. The aim of this study was to describe and characterize medication errors (MEs) assoc...

    Authors: Henrik Lövborg, Mikael Holmlund and Staffan Hägg
    Citation: BMC Pharmacology and Toxicology 2014 15:31
  21. Cannabinoid receptor 2 (CB2) is expressed predominantly in the immune system, particularly in plasma cells, raising the possibility that targeting the CB2 pathway could yield an immunomodulatory effect. Althou...

    Authors: Rentian Feng, Christine A Milcarek and Xiang-Qun Xie
    Citation: BMC Pharmacology and Toxicology 2014 15:30
  22. Regulator of G protein signaling (RGS) proteins suppress G protein coupled receptor signaling by catalyzing the hydrolysis of Gα-bound guanine nucleotide triphosphate. Transgenic mice in which RGS-mediated reg...

    Authors: Sergio Parra, Xinyan Huang, Raelene A Charbeneau, Susan M Wade, Kuljeet Kaur, Boyd R Rorabaugh and Richard R Neubig
    Citation: BMC Pharmacology and Toxicology 2014 15:29
  23. Chemotherapy with doxorubicin is limited by cardiotoxicity. Free radical generation and mitochondrial dysfunction are thought to contribute to doxorubicin-induced cardiac failure. In this study we wanted to in...

    Authors: Lisa Drange Hole, Terje Hjalmar Larsen, Kjell Ove Fossan, Fredrik Limé and Jan Schjøtt
    Citation: BMC Pharmacology and Toxicology 2014 15:28
  24. Tamoxifen, an agonist of estrogen receptor, is widely prescribed for the prevention and long-term treatment of breast cancer. A side effect of tamoxifen is fatty liver, which increases the risk for non-alcohol...

    Authors: Thuc T Le, Yasuyo Urasaki and Giuseppe Pizzorno
    Citation: BMC Pharmacology and Toxicology 2014 15:27
  25. Antimicrobial resistance (AMR) is a major global public health problem both in hospital and community acquired infections. The present study assessed the knowledge and beliefs on AMR among physicians and nurse...

    Authors: Bayeh Abera, Mulugeta Kibret and Wondemagegn Mulu
    Citation: BMC Pharmacology and Toxicology 2014 15:26
  26. Novobiocin is a coumarin antibiotic, which affects also eukaryotic cells inhibiting activity of Heat shock protein 90 (Hsp90). The Hsp90 represents a molecular chaperone critical for stabilization and activati...

    Authors: Anna K Szkaradkiewicz, Tomasz M Karpiński and Andrzej Szkaradkiewicz
    Citation: BMC Pharmacology and Toxicology 2014 15:25
  27. HIV-infected pregnant women are particularly more susceptible to the deleterious effects of malaria infection particularly anaemia. In order to prevent opportunistic infections and malaria, a policy of daily c...

    Authors: Vicent P Manyanga, Omary Minzi and Billy Ngasala
    Citation: BMC Pharmacology and Toxicology 2014 15:24
  28. The “molecular tweezer” CLR01 is a broad-spectrum inhibitor of abnormal protein self-assembly, which acts by binding selectively to Lys residues. CLR01 has been tested in several in vitro and in vivo models of am...

    Authors: Aida Attar, Wai-Ting Coco Chan, Frank-Gerrit Klärner, Thomas Schrader and Gal Bitan
    Citation: BMC Pharmacology and Toxicology 2014 15:23
  29. It is unclear whether concomitant use of clopidogrel and proton-pump inhibitors (PPIs) increases the risk of recurrence of cardiovascular disease or death in patients at high risk of upper gastrointestinal (GI...

    Authors: Qing Wang, Rickard Ljung, Jesper Lagergren and Yunxia Lu
    Citation: BMC Pharmacology and Toxicology 2014 15:22
  30. Meropenem is a carbapenem antibiotic commonly used in critically ill patients to treat severe infections. The available pharmacokinetic (PK) data has been mostly obtained from healthy volunteers as well as fro...

    Authors: João Goncalves-Pereira, Nuno Elvas Silva, André Mateus, Catarina Pinho and Pedro Povoa
    Citation: BMC Pharmacology and Toxicology 2014 15:21
  31. Changes in antihypertensive drug treatment are paramount in the adequate management of patients with hypertension, still, there is little information regarding changes in antihypertensive drug treatment in Swi...

    Authors: Vanessa Christe, Gérard Waeber, Peter Vollenweider and Pedro Marques-vidal
    Citation: BMC Pharmacology and Toxicology 2014 15:20
  32. GPR40 is a G-protein coupled receptor regulating free fatty acid induced and also glucose induced insulin secretion. We generated neonatally-streptozotocin-treated female rats (n-STZ) and treated them with CNX...

    Authors: Venkategowda Sunil, Mahesh Kumar Verma, Anup M Oommen, Manojkumar Sadasivuni, Jaideep Singh, Dasarahalli N Vijayraghav, Bhawna Chandravanshi, Jayalaxmi Shetty, Sanghamitra Biswas, Anilkumar Dandu, Yoganand Moolemath, Marikunte V Venkataranganna, Baggavalli P Somesh and Madanahalli R Jagannath
    Citation: BMC Pharmacology and Toxicology 2014 15:19
  33. This study describes the development of Response Surface Pathway (RSP) design, assesses its performance and effectiveness in estimating LD50, and compares RSP with Up and Down Procedures (UDPs) and Random Walk (R...

    Authors: Sagita Dewi, Tore Aune, John A Aasen Bunæs, Adrian J Smith and Stig Larsen
    Citation: BMC Pharmacology and Toxicology 2014 15:18
  34. Internationally, there is concern about the increased prescribing of pharmaceutical opioids for chronic non-cancer pain (CNCP). In part, this is related to limited knowledge about the long-term benefits and ou...

    Authors: Gabrielle Campbell, Richard Mattick, Raimondo Bruno, Briony Larance, Suzanne Nielsen, Milton Cohen, Nicholas Lintzeris, Fiona Shand, Wayne D Hall, Bianca Hoban, Chyanne Kehler, Michael Farrell and Louisa Degenhardt
    Citation: BMC Pharmacology and Toxicology 2014 15:17
  35. Macrophages are equipped with several receptors for the recognition of foreign particles and pathogens. Upon binding to these receptors, particles become internalized. An interaction of particles with macropha...

    Authors: Ebru Diler, Marion Schwarz, Ruth Nickels, Michael D Menger, Christoph Beisswenger, Carola Meier and Thomas Tschernig
    Citation: BMC Pharmacology and Toxicology 2014 15:16
  36. A convergence of technological breakthroughs in the past decade has facilitated the development of rapid screening tools for biomarkers of toxicant exposure and effect. Platforms using the whole adult organism...

    Authors: Naissan Hussainzada, John A Lewis, Christine E Baer, Danielle L Ippolito, David A Jackson and Jonathan D Stallings
    Citation: BMC Pharmacology and Toxicology 2014 15:15
  37. The human ether-a-go-go related gene 1 (hERG1), which codes for a potassium ion channel, is a key element in the cardiac delayed rectified potassium current, IKr, and plays an important role in the normal repolar...

    Authors: Serdar Durdagi, Trevor Randall, Henry J Duff, Adam Chamberlin and Sergei Y Noskov
    Citation: BMC Pharmacology and Toxicology 2014 15:14
  38. Access to good-quality medicines in many countries is largely hindered by the rampant circulation of spurious/falsely labeled/falsified/counterfeit (SFFC) and substandard medicines. In 2006, the Ministry of He...

    Authors: Naoko Yoshida, Mohiuddin Hussain Khan, Hitomi Tabata, Eav Dararath, Tey Sovannarith, Heng Bun Kiet, Nam Nivanna, Manabu Akazawa, Hirohito Tsuboi, Tsuyoshi Tanimoto and Kazuko Kimura
    Citation: BMC Pharmacology and Toxicology 2014 15:13
  39. Bone graft substitute such as calcium sulfate are frequently used as carrier material for local antimicrobial therapy in orthopedic surgery. This study aimed to assess the systemic absorption and disposition o...

    Authors: Françoise Livio, Peter Wahl, Chantal Csajka, Emanuel Gautier and Thierry Buclin
    Citation: BMC Pharmacology and Toxicology 2014 15:12
  40. Because of relatively small treatment numbers together with low adverse drug reaction (ADR) reporting rates the timely identification of ADRs affecting children and young people is problematic. The primary obj...

    Authors: Angela Peichen Sun, Bradley Kirby, Corri Black, Peter John Helms, Marion Bennie and James Stuart McLay
    Citation: BMC Pharmacology and Toxicology 2014 15:11
  41. Pain is characterized as a complex experience, dependent not only on the regulation of nociceptive sensory systems, but also on the activation of mechanisms that control emotional processes in limbic brain are...

    Authors: Gulnazi Gurtskaia, Nana Tsiklauri, Ivliane Nozadze, Marina Nebieridze and Merab G Tsagareli
    Citation: BMC Pharmacology and Toxicology 2014 15:10
  42. Filgrastim or methionyl-granulocyte colony-stimulating factor (Met-G-CSF), is a recombinant therapeutic protein widely used to treat severe neutropenia caused by myelosuppressive drugs in patients with nonmyel...

    Authors: Davide Crobu, Gaia Spinetti, Rodolfo Schrepfer, Giancarlo Tonon, Gloria Saccani Jotti, Pierluigi Onali, Simona Dedoni, Gaetano Orsini and Andrea Di Stefano
    Citation: BMC Pharmacology and Toxicology 2014 15:7
  43. The irrational overuse of antibiotics should be minimized as it drives the development of antibiotic resistance, but changing these practices is challenging. A better understanding is needed of practices and e...

    Authors: Do Thi Thuy Nga, Nguyen Thi Kim Chuc, Nguyen Phuong Hoa, Nguyen Quynh Hoa, Nguyen Thi Thuy Nguyen, Hoang Thi Loan, Tran Khanh Toan, Ho Dang Phuc, Peter Horby, Nguyen Van Yen, Nguyen Van Kinh and Heiman FL Wertheim
    Citation: BMC Pharmacology and Toxicology 2014 15:6
  44. Due to the recent European legislations posing a ban of animal tests for safety assessment within the cosmetic industry, development of in vitro alternatives for assessment of skin sensitization is highly priorit...

    Authors: Ann-Sofie Albrekt, Henrik Johansson, Anna Börje, Carl Borrebaeck and Malin Lindstedt
    Citation: BMC Pharmacology and Toxicology 2014 15:5
  45. Drug use evaluation is a performance improvement method that focuses on evaluating and improving drug use process to achieve optimal patient outcomes. Drug use evaluation helps in identifying, preventing or re...

    Authors: Berhanu Geresu, Desye Misganaw and Yeshiwork Beyene
    Citation: BMC Pharmacology and Toxicology 2014 15:4
  46. Since the skin represents a common site of adverse drug reactions, few data are reported at this time regarding the development of skin rash during the treatment with antidiabetic drugs.

    Authors: Laura Mumoli, Antonio Gambardella, Angelo Labate, Elena Succurro, Giovambattista De Sarro, Franco Arturi and Luca Gallelli
    Citation: BMC Pharmacology and Toxicology 2014 15:3
  47. CLP is an orally administered, non-absorbed, superabsorbent polymer being developed to increase fecal excretion of sodium, potassium and water in patients with heart failure and end-stage renal disease. This s...

    Authors: Lee W Henderson, Howard C Dittrich, Alan Strickland, Thomas M Blok, Richard Newman, Thomas Oliphant and Detlef Albrecht
    Citation: BMC Pharmacology and Toxicology 2014 15:2
  48. Oxaliplatin-based regimens induce a potential risk of hypersensitivity reaction (HSR), with incidence varying from 10% to 25% and lack of clearly identified risk factors. The present study aimed to assess inci...

    Authors: Marie Parel, Florence Ranchon, Audrey Nosbaum, Benoit You, Nicolas Vantard, Vérane Schwiertz, Chloé Gourc, Noémie Gauthier, Marie-Gabrielle Guedat, Sophie He, Eléna Kiouris, Céline Alloux, Thierry Vial, Véronique Trillet-Lenoir, Gilles Freyer, Frédéric Berard…
    Citation: BMC Pharmacology and Toxicology 2014 15:1
Reviewer acknowledgments

Annual Journal Metrics

Peer-review Terminology

  • The following summary describes the peer review process for this journal:

    Identity transparency: Single anonymized

    Reviewer interacts with: Editor

    Review information published: Review reports. Reviewer Identities reviewer opt in. Author/reviewer communication

    More information is available here

Sign up for article alerts and news from this journal