Articles

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Anakinra pharmacokinetics in children and adolescents with systemic-onset juvenile idiopathic arthritis and autoinflammatory syndromes

Anakinra pharmacokinetics and pharmacodynamics were investigated in children and adolescents treated for systemic-onset juvenile idiopathic arthritis (SJIA) and autoinflammatory syndromes.

Authors: Saik Urien, Christophe Bardin, Brigitte Bader-Meunier, Richard Mouy, Sandrine Compeyrot-Lacassagne, Franz Foissac, Benoît Florkin, Carine Wouters, Bénédicte Neven, Jean-Marc Treluyer and Pierre Quartier

Citation: BMC Pharmacology and Toxicology 2013 14:40

Content type: Research article Published on: 5 August 2013
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Memory loss during lenalidomide treatment: a report on two cases

There are many reports of cognitive dysfunction in patients receiving chemotherapy or targeted therapies. Many antineoplastic agents may be involved in the condition also known as “chemo brain” or “chemo fog”.

Authors: Adeline Rollin-Sillaire, Xavier Delbeuck, Marianne Pollet, Marie-Anne Mackowiak, Pierre Lenfant, Marie-Pierre Noel, Thierry Facon, Xavier Leleu, Florence Pasquier and Emilie Le Rhun

Citation: BMC Pharmacology and Toxicology 2013 14:41

Content type: Case report Published on: 12 August 2013
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Lessons from tissue-specific KO of CNP/GC-B system - everlasting challenge to clinical application

Authors: Kazuwa Nakao, Koitiro Kuwahara, Hiroaki Yasoda, Goro Katuura, Kazuhiro Nakao, Kazumasa Nakao and Yui Yamasita

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O4

Content type: Oral presentation Published on: 29 August 2013

This article is part of a Supplement: Volume 14 Supplement 1
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A possible crosstalk between cGMP pathway and Activin receptor-like kinase 7 (Alk7) in adipocytes

Authors: Aileen Balkow, Johanna Jagow, Ana Kilic and Alexander Pfeifer

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P4

Content type: Poster presentation Published on: 29 August 2013

This article is part of a Supplement: Volume 14 Supplement 1
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Genetic variants in guanylyl cyclase and phoshodiesterase affecting coronary disease risk

Authors: Heribert Schunkert

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O6

Content type: Oral presentation Published on: 29 August 2013

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Genetic modifiers of hypertension in sGC-deficient mice

Authors: Emmanuel Buys

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O8

Content type: Oral presentation Published on: 29 August 2013

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Role of NO-sensitive guanylyl cyclase in angiogenesis and arteriogenesis

Authors: Noomen Bettaga, Andreas Friebe and Ronald Jäger

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P8

Content type: Poster presentation Published on: 29 August 2013

This article is part of a Supplement: Volume 14 Supplement 1
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Identification of protein kinase G I alpha interacting proteins as potential targets to prevent cardiac remodeling

Authors: Robert Blanton, Angela Lane, Mark Aronovitz, Guang-Rong Wang, Robrecht Thoonen, Roger Davis, Michael Mendelsohn, David Kass and Richard Karas

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P10

Content type: Poster presentation Published on: 29 August 2013

This article is part of a Supplement: Volume 14 Supplement 1
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cGMP kinase: past, presence and future

Authors: Franz Hofmann, Florian Loga, Katrin Domes, Enrico Patrucco and Jörg W Wegener

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O11

Content type: Oral presentation Published on: 29 August 2013

This article is part of a Supplement: Volume 14 Supplement 1
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cGMP-dependent protein kinase Iβ phosphorylates and regulates the function of the actin/myosin-associatedprotein caldesmon

Authors: Darren E Casteel, Raphaela Schwappacher, Hema Rangaswami and Jacqueline Su-Yuo

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P13

Content type: Poster presentation Published on: 29 August 2013

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A twenty year journey to understand how ATP activates guanylyl cyclase A and B

Authors: Lincoln R Potter

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O13

Content type: Oral presentation Published on: 29 August 2013

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Synthesis and evaluation of bifunctional sGC regulators

Authors: Mikolaj Chrominski, Dorota Gryko, Iraida Sharina and Emil Martin

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P15

Content type: Poster presentation Published on: 29 August 2013

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Crystal structures of human soluble guanylate cyclase catalytic domains: promiscuity of the dimer interface and a potential allosteric site

Authors: Opher Gileadi, Charles Allerston and Frank von Delft

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O15

Content type: Oral presentation Published on: 29 August 2013

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A tissue based chemical proteomics screen to identify novel G-kinase associated proteins (GKAPs)

Authors: Eleonora Corradini, Pepijn P Burgers, Michael Plank, Albert JR Heck and Arjen Scholten

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P16

Content type: Poster presentation Published on: 29 August 2013

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Defining the molecular targets of cerebellar PKG by quantitative (phospho)proteomics in a knock-out mouse model

Authors: Eleonora Corradini, Robert Feil, Albert JR Heck and Arjen Scholten

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P17

Content type: Poster presentation Published on: 29 August 2013

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Targeting native and apo-sGC

Authors: Mary Struthers, Subharekha Raghavan, Ronald Kim, Christopher Sinz, Sophie Roy and Michael Mendelsohn

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O17

Content type: Oral presentation Published on: 29 August 2013

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A novel role of the natriuretic peptide/cGMP/cGKI pathway in melanoma cells

Authors: Sandeep Dhayade, Susanne Feil, Christoph Griessinger, Manfred Kneilling, Birgit Schittek and Robert Feil

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P19

Content type: Poster presentation Published on: 29 August 2013

This article is part of a Supplement: Volume 14 Supplement 1
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Redox signalling by protein kinase G Iα in cardiovascular physiology and pathology

Authors: Philip Eaton

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O19

Content type: Oral presentation Published on: 29 August 2013

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The soluble guanylyl cyclase stimulator BAY 41-2272 increases differentiation and function of brown adipocytes

Authors: Jennifer Etzrodt, Linda S Hoffmann, Andreas Friebe and Alexander Pfeifer

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P20

Content type: Poster presentation Published on: 29 August 2013

This article is part of a Supplement: Volume 14 Supplement 1
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Soluble guanylyl cyclase as a therapeutic target in chronic obstructive pulmonary disease (COPD)

Authors: Constantinos Glynos, Dimitris Toumpanakis, Zongmin Zhou, Peter Brouckaert, Theodoros Vassilakopoulos and Andreas Papapetropoulos

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P25

Content type: Poster presentation Published on: 29 August 2013

This article is part of a Supplement: Volume 14 Supplement 1
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Role of cGMP in fat and metabolism

Authors: Alexander Pfeifer, Ana Kilić and Linda Hoffmann

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O25

Content type: Oral presentation Published on: 29 August 2013

This article is part of a Supplement: Volume 14 Supplement 1
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Cardiovascular response to NO donors in mice deficient in NO-GC

Authors: Dieter Groneberg, Anna Schlembach and Andreas Friebe

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P27

Content type: Poster presentation Published on: 29 August 2013

This article is part of a Supplement: Volume 14 Supplement 1
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cGMP-Prkg1 signaling PDE5 inhibition shelter cochlear hair cells and hearing function

Authors: Marlies Knipper, Mirko Jaumann, Francois Paquet-Durand, Peter Ruth, Peter Sandner, Robert Feil, Jutta Engel and Lukas Rüttiger

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O27

Content type: Oral presentation Published on: 29 August 2013

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Urinary cGMP concentrations after exposure to radio-contrast media in patient at risk for contrast media induced nephropathy (CIN) predicts 90-day morbidity and mortality

Authors: Berthold Hocher, Fabian Heunisch, Gina-Franziska von Einem, Markus Alter, Yvonne Keim and Johannes-Peter Stasch

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P29

Content type: Poster presentation Published on: 29 August 2013

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Cell type-specific knock out models to unravel NO/cGMP signaling in smooth muscle

Authors: Noomen Bettaga, Dieter Groneberg, Ronald Jäger, Barbara Lies and Andreas Friebe

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O29

Content type: Oral presentation Published on: 29 August 2013

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cGMP-dependent kinase 2, Na⁺/H⁺ regulatory factor 2, and Na⁺/H⁺ exchanger isoform 3 assemble within lipid rafts in murine small intestinal brush border membrane

Authors: Min Luo, Ayesha Sultan, Qin Yu, Brigitte Riederer, Weiliang Xia, Min Luo, Mingmin Chen, Simone Lissner, Engelbert Gessner, Enrico Patrucco, Franz Hofmann, Mark Donowitz, Chris C Yun, Hugo de Jonge, Georg Lamprecht and Ursula Seidler

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O31

Content type: Oral presentation Published on: 29 August 2013

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67-kDa laminin receptor and cGMP induced cancer-selective apoptosis

Authors: Motofumi Kumazoe and Hirofumi Tachibana

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O33

Content type: Oral presentation Published on: 29 August 2013

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Localization and function of NO-GC in the murine gastrointestinal and lower urinary tract

Authors: Barbara Lies, Dieter Groneberg, Dieter Saur and Andreas Friebe

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P37

Content type: Poster presentation Published on: 29 August 2013

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Nitric oxide regulated cyclic di-GMP signaling

Authors: Elizabeth M Boon, Zhou Dai, Niu Liu, Bernadette Henares, Dhruv Arora and Tanaya Lahiri

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O37

Content type: Oral presentation Published on: 29 August 2013

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Metabolic fate of orally administered cGMP in rats

Authors: Elaine Liong, Christopher Graul, Samuel Rivers, Marco Kessler, Gerhard Hannig and Inmaculada Silos-Santiago

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P39

Content type: Poster presentation Published on: 29 August 2013

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Transforming PKA into PKG – a structure-function approach to understand cyclic nucleotide selectivity

Authors: Robin Lorenz, Eui-Whan Moon, Gilbert Y Huang, Albert S Reger, Jeong J Kim, Eugen Franz, Daniela Bertinetti, Choel Kim and Friedrich W Herberg

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P41

Content type: Poster presentation Published on: 29 August 2013

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M-atrial natriuretic peptide and nitroglycerin in experimental acute hypertensive heart failure: differential actions of two cGMP activating therapeutics

Authors: Paul M McKie, Alessandro Cataliotti, Tomoko Ichiki, S Jeson Sangaralingham, Horng H Chen and John C Burnett Jr

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P43

Content type: Poster presentation Published on: 29 August 2013

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Endothelial dysfunction in adipose triglyceride lipase deficiency: role of perivascular adipose tissue

Authors: Marion Mussbacher, Karoline Pail, Gerald Wölkart, Günter Hämmerle, Alois Lametschwandtner, Rudolf Zechner, Bernd Mayer and Astrid Schrammel

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P45

Content type: Poster presentation Published on: 29 August 2013

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The good and the ugly: ANP antagonizes the deleterious effects of aldosterone in hypertensive cardiac remodeling

Authors: Hitoshi Nakagawa, Katharina Völker, Heike Oberwinkler, Birgit Gaßner, Charlotte Dienesch, Sandra Umbenhauer, Hideo A Baba, Stefan Frantz and Michaela Kuhn

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P46

Content type: Poster presentation Published on: 29 August 2013

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The effects of super-flux (high performance) dialyzer on the plasma glycosylated pro-B-type natriuretic peptide (proBNP) and glycosylated N-terminal proBNP in end-stage renal disease patients on dialysis

Authors: Yasuaki Nakagawa, Toshio Nishikimi, Naoto Minamino, Chinatsu Yamada, Kazuhiro Nakao, Takeya Minami, Yoshihiro Kuwabara, Hideyuki Kinoshita, Shinji Yasuno, Kenji Ueshima, Koichiro Kuwahara, Kenji Kangawa and Kazuwa Nakao

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P47

Content type: Poster presentation Published on: 29 August 2013

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Impact of local CNP/GC-B system in growth plates on endochondral bone growth

Authors: Kazumasa Nakao, Akihiro Yasoda, Kenji Osawa, Toshihito Fujii, Eri Kondo, Noriaki Koyama, Naotetsu Kanamoto, Masako Miura, Koichiro Kuwahara, Haruhiko Akiyama, Kazuhisa Bessho and Kazuwa Nakao

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P48

Content type: Poster presentation Published on: 29 August 2013

This article is part of a Supplement: Volume 14 Supplement 1
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O-glycosylated pro-B-type natriuretic peptide is cleaved intracellularly by furin in ventricular and atrial myocytes: importance of the distance between the O-glycosylation and cleavage sites

Authors: Toshio Nishikimi, Yasuaki Nakagawa, Naoto Minamino, Masashi Ikeda, Toshihiko Ishimitsu, Chinatsu Yamada, Kazuhiro Nakao, Takeya Minami, Yoshihiro Kuwabara, Hideyuki Kinoshita, Koichiro Kuwahara, Kenji Kangawa and Kazuwa Nakao

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P50

Content type: Poster presentation Published on: 29 August 2013

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ANP/GC-A signaling attenuates tissue injury by cisplatin

Authors: Takashi Nojiri, Hiroshi Hosoda, Toru Kimura and Kenji Kangawa

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P51

Content type: Poster presentation Published on: 29 August 2013

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ANP/GC-A signaling attenuates pulmonary metastasis of B16 melanoma enhanced by lipopolysaccharide or angiotensin-II

Authors: Takashi Nojiri, Hiroshi Hosoda, Shin Ishikane, Toru Kimura and Kenji Kangawa

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P52

Content type: Poster presentation Published on: 29 August 2013

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Protective role of endogenous cardiac natriuretic peptide/GC-A system on the maternal heart during the postpartum period

Authors: Kentaro Otani, Takeshi Tokudome, Ichiro Kishimoto, Yuanjie Mao, Kenichi Yamahara, Kazuwa Nakao and Kenji Kangawa

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P53

Content type: Poster presentation Published on: 29 August 2013

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Determination of cGMP levels in rodent tissues following oral dosing of a soluble guanylate cyclase stimulator

Authors: Nisha Perez, Christopher Graul, Peter Germano, Erik Solberg, Samuel Rivers, Robert Solinga, Joel Moore, Gerhard Hannig, Ada Silos-Santiago, Robert Busby and Daniel Zimmer

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P54

Content type: Poster presentation Published on: 29 August 2013

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The nitroxyl donor isopropylamine-NONOate elicits soluble guanylyl cyclase-dependent antihypertrophic actions: comparison of the potential therapeutic advantages of HNO over NO•

Authors: Rebecca Ritchie, Jennifer Irvine, Nga Cao, Swati Gossain, Amy Alexander, Jane Love, Chengxue Qin, John D Horowitz and Barbara K Kemp-Harper

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P56

Content type: Poster presentation Published on: 29 August 2013

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Protein kinase G oxidation contribute to hypotension and organ injury during sepsis

Authors: Olena Rudyk, Alkystis Phinikaridou, Oleksandra Prysyazhna, Joseph R Burgoyne, Rene Botnar and Philip Eaton

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P58

Content type: Poster presentation Published on: 29 August 2013

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Influence of PKG on insulin signalling and GSK3 phosphorylation in SH-SY5Y cells

Authors: Abhishek Sanyal, Didier Lochmatter, Anne Preußner and Alexander Pfeifer

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P60

Content type: Poster presentation Published on: 29 August 2013

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Endothelial dysfunction in a mouse model of human neutral lipid storage disease

Authors: Astrid Schrammel, Marion Mussbacher, Gerald Wölkart, Heike Stessel, Günter Hämmerle, Wael Al Zoughbi, Gerald Höfler, Alois Lametschwandtner, Rudolf Zechner and Bernd Mayer

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P64

Content type: Poster presentation Published on: 29 August 2013

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Genetic silencing of sGC β1 in cancer: role of epigenetic regulation

Authors: Alex Sotolongo, Ka Bian and Ferid Murad

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P66

Content type: Poster presentation Published on: 29 August 2013

This article is part of a Supplement: Volume 14 Supplement 1
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Linaclotide induces secretion of cGMP from mouse colonic epithelium

Authors: Boris Tchernychev, Sarah Jacobson, Caroline Kurtz, Mark Currie and Inmaculada Silos-Santiago

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P70

Content type: Poster presentation Published on: 29 August 2013

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NO/cGMP/pCREB re-activation reverses cognition deficits and attenuates amyloid-β neuropathology in transgenic models of Alzheimer’s disease

Authors: Gregory RJ Thatcher, Jia Luo, Lawren VandeVrede, Zhihui Qin, Sue Lee, Ramy Abdelhamid, Brian M Bennett, Mary Jo LaDu, Leon Tai and John Larson

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P72

Content type: Poster presentation Published on: 29 August 2013

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Phospho-specific antisera to monitor N-terminal autophosphorylation of cGMP-dependent protein kinase type I

Authors: Raghavan Vallur, Hubert Kalbacher, Jana Krauß and Robert Feil

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P74

Content type: Poster presentation Published on: 29 August 2013

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Identification of cCMP binding and activated proteins

Authors: Stefanie Wolfertstetter, Elisabeth Schinner, Franz Hofmann and Jens Schlossmann

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P78

Content type: Poster presentation Published on: 29 August 2013

This article is part of a Supplement: Volume 14 Supplement 1
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