Fineman MS, Cirincione BB, Maggs D, Diamant M: GLP-1 based therapies: differential effects on fasting and postprandial glucose. Diabetes Obes Metab. 2012, 14: 675-688. 10.1111/j.1463-1326.2012.01560.x.
Article
CAS
PubMed
Google Scholar
Richter B, Bandeira-Echtler E, Bergerhoff K, Clar C, Ebrahim SH: Pioglitazone for type 2 diabetes mellitus. Cochrane Database Syst Rev. 2006, 18: CD006060
Google Scholar
Sreenan S, Sturis J, Pugh W, Burant CF, Polonsky KS: Prevention of hyperglycemia in the Zucker diabetic fatty rat by treatment with metformin or troglitazone. Am J Physiol. 1996, 271: 742-747.
Google Scholar
Briscoe CP, Peat AJ, McKeown SC, Corbett DF, Goetz AS, Littleton TR, McCoy DC, Kenakin TP, Andrews JL, Ammala C, Fornwald JA, Ignar DM, Jenkinson S: Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules. Br J Pharmacol. 2009, 148: 619-628.
Article
Google Scholar
Shapiro H, Shachar S, Sekler I, Hershfinkel M, Walker MD: Role of GPR40 in fatty acid action on the beta cell line INS-1E. Biochem Biophys Res Commun. 2005, 335: 97-104. 10.1016/j.bbrc.2005.07.042.
Article
CAS
PubMed
Google Scholar
Fujiwara K, Maekawa F, Yada T: Oleic acid interacts with GPR40 to induce Ca2+ signaling in rat islet beta-cells: mediation by PLC and L-type Ca2+ channel and link to insulin release. Am J Physiol Endocrinol Metab. 2005, 289: 670-677. 10.1152/ajpendo.00035.2005.
Article
Google Scholar
Tan CP, Feng Y, Zhou YP, Eiermann GJ, Petrov A, Zhou C, Lin S, Salituro G, Meinke P, Mosley R, Akiyama TE, Einstein M, Kumar S, Berger JP, Mills SG, Thornberry NA, Yang L, Howard AD: Selective small-molecule agonists of G protein-coupled receptor 40 promote glucose-dependent insulin secretion and reduce blood glucose in mice. Diabetes. 2008, 57: 2211-2219. 10.2337/db08-0130.
Article
CAS
PubMed
PubMed Central
Google Scholar
Tsujihata Y, Ito R, Suzuki M, Harada A, Negoro N, Yasuma T, Momose Y, Takeuchi K: TAK-875, an orally available G protein-coupled receptor 40/free fatty acid receptor 1 agonist, enhances glucose-dependent insulin secretion and improves both postprandial and fasting hyperglycemia in type 2 diabetic rats. J Pharmacol Exp Ther. 2011, 339: 228-327. 10.1124/jpet.111.183772.
Article
CAS
PubMed
Google Scholar
Lin DC, Zhang J, Zhuang R, Li F, Nguyen K, Chen M, Tran T, Lopez E, Lu JY, Li XN, Tang L, Tonn GR, Swaminath G, Reagan JD, Chen JL, Tian H, Lin YJ, Houze JB, Luo J: AMG 837: a novel GPR40/FFA1 agonist that enhances insulin secretion and lowers glucose levels in rodents. PLoS One. 2011, 6: e27270-10.1371/journal.pone.0027270.
Article
CAS
PubMed
PubMed Central
Google Scholar
Luo J, Swaminath G, Brown SP, Zhang J, Guo Q, Chen M, Nguyen K, Tran T, Miao L, Dransfield PJ, Vimolratana M, Houze JB, Wong S, Toteva M, Shan B, Li F, Zhuang R, Lin DC: A Potent class of GPR40 full agonists engages the enteroinsular axis to promote glucose control in rodents. PLoS One. 2012, 7: e46300-10.1371/journal.pone.0046300.
Article
CAS
PubMed
PubMed Central
Google Scholar
Burant CF, Viswanathan P, Marcinak J, Cao C, Vakilynejad M, Xie B, Leifke E: TAK-875 versus placebo or glimepiride in type 2 diabetes mellitus: a phase 2, randomised, double-blind, placebo-controlled trial. Lancet. 2012, 379: 1403-1411. 10.1016/S0140-6736(11)61879-5.
Article
CAS
PubMed
Google Scholar
Kaku K, Araki T, Yoshinaka R: Randomized, Double-Blind, Dose-Ranging Study of TAK-875, a Novel GPR40 Agonist, in Japanese Patients With Inadequately Controlled Type 2 Diabetes. Diabetes Care. 2013, 36: 245-250. 10.2337/dc12-0872.
Article
CAS
PubMed
PubMed Central
Google Scholar
Tokuyama Y, Sturis J, DePaoli AM, Takeda J, Stoffel M, Tang J, Sun X, Polonsky KS, Bell GI: Evolution of beta cell dysfunction in the male Zucker diabetic fatty rat. Diabetes. 1995, 44: 1447-1457. 10.2337/diabetes.44.12.1447.
Article
CAS
PubMed
Google Scholar
Yuen VG, Vera E, Battell ML, Li WM, McNeill JH: Acute and chronic oral administration of bis(maltolato) oxovanadium (IV) in Zucker diabetic fatty (ZDF) rats. Diabetes Res Clin Pract. 1999, 43: 9-19. 10.1016/S0168-8227(98)00120-X.
Article
CAS
PubMed
Google Scholar
Carter JD, Dula SB, Corbin KL, Wu R, Nunemaker CS: A practical guide to rodent islet isolation and assessment. Biol Proced Online. 2009, 11: 3-31. 10.1007/s12575-009-9021-0.
Article
CAS
PubMed
PubMed Central
Google Scholar
Luna L: AFIP Manual of Histological Staining Methods. 1968, New York: McGraw Hill
Google Scholar
Culling CFA, Allison RT, Bair WT: Cellular pathology technique. 1985, London: Butterworths
Google Scholar
Kerr JFR, Wyllie AH, Currie AR: Apoptosis: a basic biological phenomenon with wideranging implications in tissue kinetics. Br J Cancer. 1972, 26: 239-257. 10.1038/bjc.1972.33.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wyllie AH, Kerr JFR, Currie AR: Cell death: the significance of apoptosis. Int Rev Cytol. 1980, 68: 251-306.
Article
CAS
PubMed
Google Scholar
Garrity MM, Burgart LJ, Riehle DL, Hill EM, Sebo TJ, Witzig T: Identifying and Quantifying Apoptosis: Navigating Technical Pitfalls. Mod Pathol. 2003, 16: 389-394. 10.1097/01.MP.0000062657.30170.92.
Article
PubMed
Google Scholar
Bruin JE, Gerstein HC, Morrison KM, Holloway AC: Increased pancreatic beta cell apoptosis following fetal and neonatal exposure to nicotine is mediated via the mitochondria. Toxicol Sci. 2008, 103: 362-370. 10.1093/toxsci/kfn012.
Article
CAS
PubMed
Google Scholar
Watari N, Tsukagoshi N, Honma Y: The correlative light and electron microscopy of the islets of Langerhans in some lower vertebrates. Arch Histol. 1970, 31: 371-392. 10.1679/aohc1950.31.371.
Article
CAS
Google Scholar
Mihail N, Craciun C: An ultrastructural description of the cell types in the endocrine pancreas of the pigeon. Anat Anz Jena. 1982, 152: 229-237.
CAS
Google Scholar
Misawa E, Tanaka M, Nomaguchi K, Nomaguchia K, Yamada M, Toida T, Takase M, Iwatsuki K, Kawada T: Administration of phytosterols isolated from aloe vera gel reduce visceral fat mass and improve hyperglycemia in Zucker diabetic fatty (zdf) rats. Obes Res Clin Pract. 2008, 2: 239-245. 10.1016/j.orcp.2008.06.002.
Article
Google Scholar
Del Prato S: Loss of early insulin secretion leads to postprandial hyperglycaemia. Diabetologia. 2003, 46: 2-8.
Google Scholar
Rebrin K, Steil GM, Getty L, Bergman RN: Free fatty acid as a link in the regulation of hepatic glucose output by peripheral insulin. Diabetes. 1995, 44: 1038-1045. 10.2337/diabetes.44.9.1038.
Article
CAS
PubMed
Google Scholar
Koopmans SJ, Sips HC, Bosman J, Radder JK, Krans HM: Antilipolytic action of insulin in adipocytes from starved and diabetic rats during adenosine-controlled incubations. Endocrinology. 1989, 125: 3044-3050. 10.1210/endo-125-6-3044.
Article
CAS
PubMed
Google Scholar
Bajaj M, Suraamornkul S, Romanelli A, Cline GW, Mandarino LJ, Shulman GI, DeFronzo RA: Effect of a sustained reduction in plasma free fatty acid concentration on intramuscular long-chain fatty Acyl-CoAs and insulin action in type 2 diabetic patients. Diabetes. 2005, 54: 3148-3153. 10.2337/diabetes.54.11.3148.
Article
CAS
PubMed
Google Scholar
Sugden MC, Holness MJ: Potential role of peroxisome proliferator-activated receptor-alpha in the modulation of glucose-stimulated insulin secretion. Diabetes. 2004, 53 (Suppl 1): S71-S81.
Article
CAS
PubMed
Google Scholar
Frigerio F, Brun T, Bartley C, Usardi A, Bosco D, Ravnskjaer K, Mandrup S, Maechler P: Peroxisome proliferator-activated receptor alpha (PPARalpha) protects against oleate-induced INS-1E beta cell dysfunction by preserving carbohydrate metabolism. Diabetologia. 2010, 53: 331-340. 10.1007/s00125-009-1590-6.
Article
CAS
PubMed
Google Scholar
Chen J, Saxena G, Mungrue IN, Lusis AJ, Shalev A: Thioredoxin-interacting protein: a critical link between glucose toxicity and beta-cell apoptosis. Diabetes. 2008, 57: 938-944. 10.2337/db07-0715.
Article
CAS
PubMed
PubMed Central
Google Scholar
Oslowski CM, Hara T, O’Sullivan-Murphy B, Kanekura K, Lu S, Hara M, Ishigaki S, Zhu LJ, Hayashi E, Hui ST, Greiner D, Kaufman RJ, Bortell R, Urano F: Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasome. Cell Metab. 2012, 16: 265-273. 10.1016/j.cmet.2012.07.005.
Article
CAS
PubMed
PubMed Central
Google Scholar
Reich E, Tamary A, Sionov RV, Melloul D: Involvement of thioredoxin-interacting protein (TXNIP) in glucocorticoid-mediated beta cell death. Diabetologia. 2012, 55: 1048-1057. 10.1007/s00125-011-2422-z.
Article
CAS
PubMed
Google Scholar
Chen J, Fontes G, Saxena G, Poitout V, Shalev A: Lack of TXNIP protects against mitochondria-mediated apoptosis but not against fatty acid-induced ER stress-mediated beta-cell death. Diabetes. 2010, 59: 440-447. 10.2337/db09-0949.
Article
CAS
PubMed
Google Scholar
Rendell M, Stephen PM, Paulsen R, Valentine JL, Rasbold K, Hestorff T, Eastberg S, Shint DC: An interspecies comparison of normal levels of glycosylated hemoglobin and glycosylated albumin. Comp Biochem Physiol B. 1985, 81: 819-822.
CAS
PubMed
Google Scholar
Wallace TM, Levy JC, Matthews DR: Use and abuse of HOMA modeling. Diabetes Care. 2004, 27: 1487-1495. 10.2337/diacare.27.6.1487.
Article
PubMed
Google Scholar
Lee Y, Hirose H, Ohneda M, Johnson JH, McGarry JD: Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships. Proc Natl Acad Sci USA. 1994, 91: 10878-10882. 10.1073/pnas.91.23.10878.
Article
CAS
PubMed
PubMed Central
Google Scholar
Pick A, Clark J, Kubstrup C, Levisetti M, Pugh W: Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat. Diabetes. 1998, 47: 358-364. 10.2337/diabetes.47.3.358.
Article
CAS
PubMed
Google Scholar
Smith SA, Lister CA, Toseland CD, Buckingham RE: Rosiglitazone prevents the onset of hyperglycaemia and proteinuria in the Zucker diabetic fatty rat. Diabetes Obes Metab. 2000, 2: 363-372. 10.1046/j.1463-1326.2000.00099.x.
Article
CAS
PubMed
Google Scholar
Sudre B, Broqua P, White RB, Ashworth D, Evans DM, Haigh R, Junien JL, Aubert ML: Chronic inhibition of circulating dipeptidyl peptidase IV by FE 999011 delays the occurrence of diabetes in male zucker diabetic fatty rats. Diabetes. 2002, 51: 1461-1469. 10.2337/diabetes.51.5.1461.
Article
CAS
PubMed
Google Scholar