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  1. Research article

    Psychotropic drug use and mortality in old people with dementia: investigating sex differences

    Psychotropic drugs are common among old people with dementia, and have been associated with increased mortality. Previous studies have not investigated sex differences in this risk. This study was conducted to...

    Jon Brännström, Gustaf Boström, Erik Rosendahl, Peter Nordström, Håkan Littbrand, Hugo Lövheim and Yngve Gustafson

    BMC Pharmacology and Toxicology 2017 18:36

    Published on: 25 May 2017

  2. Research article

    Antimicrobial resistance profile of Staphylococcus aureus isolates isolated from ear discharges of patients at University of Hawassa comprehensive specialized hospital

    Drug-resistant microorganism are a growing global danger. Strains of S. aureus have developed resistance to many commonly used antimicrobials due to indiscriminate use of antimicrobials, and treatment becoming a ...

    Serawit Deyno, Alemayehu Toma, Mesfin Worku and Muluken Bekele

    BMC Pharmacology and Toxicology 2017 18:35

    Published on: 15 May 2017

  3. Research article

    The salvage therapy in lung adenocarcinoma initially harbored susceptible EGFR mutation and acquired resistance occurred to the first-line gefitinib and second-line cytotoxic chemotherapy

    Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) such as gefitinib can provide better efficacy and prolonged progression free survival (PFS) than cytotoxic chemotherapy for metastatic lung ...

    Chih-Jen Yang, Jen-Yu Hung, Ming-Ju Tsai, Kuan-Li Wu, Ta-Chih Liu, Shah-Hwa Chou, Jui-Ying Lee, Jui-Sheng Hsu, Ming-Shyan Huang and Inn-Wen Chong

    BMC Pharmacology and Toxicology 2017 18:21

    Published on: 10 May 2017

  5. Research article

    Effects of diacetyl-liensinine on electrophysiology in rabbit ventricular myocytes

    Diacetyl-liensinine is a chemosynthetic derivative of liensinine, extracted from the seed embryo of Nelumbo nucifera Gaertn, in China. It has been found to have extensive anti- arrhythmic actions. The present stu...

    Feng Cao, Teng Wang, Wenmao Ding, Zhe Li, Shaobo Shi and Xiaozhan Wang

    BMC Pharmacology and Toxicology 2017 18:33

    Published on: 5 May 2017

  7. Research article

    Molecular mechanism of cardol, isolated from Trigona incisa stingless bee propolis, induced apoptosis in the SW620 human colorectal cancer cell line

    Cardol is a major bioactive constituent in the Trigona incisa propolis from Indonesia, with a strong in vitro antiproliferative activity against the SW620 colorectal adenocarcinoma cell line (IC50 of 4.51 ± 0.76 ...

    Paula Mariana Kustiawan, Kriengsak Lirdprapamongkol, Tanapat Palaga, Songchan Puthong, Preecha Phuwapraisirisan, Jisnuson Svasti and Chanpen Chanchao

    BMC Pharmacology and Toxicology 2017 18:32

    Published on: 4 May 2017

  8. Research article

    Erroneous formulation of delayed-release omeprazole capsules: alert for importing countries

    Poor drug quality is a matter of serious concern, especially in countries where drug regulation and law enforcement are constrained by limited resources. This study was carried out to investigate the cause of ...

    Mohammad Sofiqur Rahman, Naoko Yoshida, Hirohito Tsuboi, Tep Keila, Tey Sovannarith, Heng Bun Kiet, Eav Dararth, Theingi Zin, Tsuyoshi Tanimoto and Kazuko Kimura

    BMC Pharmacology and Toxicology 2017 18:31

    Published on: 3 May 2017

  9. Research article

    Large-scale detection of drug off-targets: hypotheses for drug repurposing and understanding side-effects

    Promiscuity in molecular interactions between small-molecules, including drugs, and proteins is widespread. Such unintended interactions can be exploited to suggest drug repurposing possibilities as well as to...

    Matthieu Chartier, Louis-Philippe Morency, María Inés Zylber and Rafael J. Najmanovich

    BMC Pharmacology and Toxicology 2017 18:18

    Published on: 28 April 2017

  10. Research article

    Salidroside contributes to reducing blood pressure and alleviating cerebrovascular contractile activity in diabetic Goto-Kakizaki Rats by inhibition of L-type calcium channel in smooth muscle cells

    Vascular disease is a common and often severe complication in diabetes mellitus. Hyperglycemia and hypertension are considered to be two of the leading risk factors for vascular complications in diabetic patie...

    Yu-Guang Ma, Jun-Wei Wang, Yun-Gang Bai, Mei Liu, Man-Jiang Xie and Zhi-Jun Dai

    BMC Pharmacology and Toxicology 2017 18:30

    Published on: 26 April 2017

  11. Research article

    Dichloroacetic acid-induced testicular toxicity in male rats and the protective effect of date fruit extract

    The present study was designed to investigate the protective effect of aqueous date extract (ADE) against the dichloroacetic acid (DCA)-induced testicular injury in rats.

    Amira El Arem, Lamia Lahouar, Emna Behija Saafi, Amira Thouri, Fatma Ghrairi, Zohra Houas, Fadoua Neffati and Lotfi Achour

    BMC Pharmacology and Toxicology 2017 18:17

    Published on: 22 April 2017

  12. Research article

    Coenzyme Q10 prevents oxidative stress and fibrosis in isoprenaline induced cardiac remodeling in aged rats

    The objective of the present study aimed to investigate the effect of CoQ10 treatment on isoprenaline (ISO)-induced cardiac remodeling in rats.

    Anayt Ulla, Mustafe Khalid Mohamed, Biswajit Sikder, AFM Towheedur Rahman, Farzana Akther Sumi, Murad Hossain, Hasan Mahmud Reza, G. M. Sayedur Rahman and Md Ashraful Alam

    BMC Pharmacology and Toxicology 2017 18:29

    Published on: 20 April 2017

  13. Research article

    Adverse drug events observed in patients with type 2 diabetes mellitus treated with 100 mg versus 300 mg canagliflozin: a systematic review and meta-analysis of published randomized controlled trials

    Nowadays, canagliflozin monotherapy, or in combination with other oral hypoglycemic agents (OHAs), is often administered in patients who are treated for type 2 diabetes mellitus (T2DM). Therefore, we aimed to ...

    Pravesh Kumar Bundhun, Girish Janoo and Feng Huang

    BMC Pharmacology and Toxicology 2017 18:19

    Published on: 16 April 2017

  14. Research article

    Mechanism of the blood pressure-lowering effect of sodium-glucose cotransporter 2 inhibitors in obese patients with type 2 diabetes

    Sodium-glucose cotransporter 2 (SGLT2) inhibitors are reported to have BP-lowering effect in addition to blood glucose-lowering effect, however, its mechanism is still unknown. This study aimed to investigate ...

    Shin Kawasoe, Yukiko Maruguchi, Shoko Kajiya, Hitoshi Uenomachi, Masaaki Miyata, Mariko Kawasoe, Takuro Kubozono and Mitsuru Ohishi

    BMC Pharmacology and Toxicology 2017 18:23

    Published on: 10 April 2017

  15. Research article

    Impact of matrix metalloproteinase 9 rs3918242 genetic variant on lipid-lowering efficacy of simvastatin therapy in Chinese patients with coronary heart disease

    Genetic variation of matrix metalloproteinase 9 (MMP-9) gene polymorphism has been suggested to modulate coronary heart diseases (CHD), yet the underlying mechanisms are not well understood.

    Yuanyuan Xu, Yan Wang, Jixin Zhi, Lichun Qi, Tong Zhang and Xueqi Li

    BMC Pharmacology and Toxicology 2017 18:28

    Published on: 8 April 2017

  16. Research article

    Genotoxicity and acute and subchronic toxicity studies of a bioactive polyoxometalate in Wistar rats

    Cs2K4Na [SiW9Nb3O40] (POM93) is a novel broad-spectrum antiviral agent with high activity, high stability, and low toxicity in vitro. Most toxicity studies for POM93 have been performed in cultured cell lines rat...

    Xiaofeng Qu, Kun Xu, Chao Zhao, Xiuling Song, Jinhua Li, Li Li, Wei Nie, Hao Bao, Juan Wang, Fenglan Niu and Juan Li

    BMC Pharmacology and Toxicology 2017 18:26

    Published on: 5 April 2017

  17. Research article

    Drug adherence for antihypertensive medications and its determinants among adult hypertensive patients attending in chronic clinics of referral hospitals in Northwest Ethiopia

    Adherence to prescribed medication is an imperative issue which can be directly linked with the management of chronic diseases like hypertension; failure to adhere can affect the effectiveness of medication as...

    Habtamu Sewunet Mekonnen, Mignote Hailu Gebrie, Kokeb Haile Eyasu and Abebaw Addis Gelagay

    BMC Pharmacology and Toxicology 2017 18:27

    Published on: 5 April 2017

  18. Research article

    Treatment adherence and persistence with long-acting somatostatin analog therapy for the treatment of acromegaly: a retrospective analysis

    Many patients with acromegaly require medical treatment that includes somatostatin analogs (SSAs). Long-acting SSA formulations are widely used, due in part to increased patient convenience and increased treat...

    Michelle H. Gurel, Yi Han, Andrea L. Stevens, Aaron Furtado and David Cox

    BMC Pharmacology and Toxicology 2017 18:22

    Published on: 4 April 2017

  20. Research article

    Pharmacokinetics of surotomycin from phase 1 single and multiple ascending dose studies in healthy volunteers

    Surotomycin, a novel, orally administered, cyclic, lipopeptide antibacterial in development for the treatment of Clostridium difficile-associated diarrhea, has demonstrated minimal intestinal absorption in animal...

    Gurudatt Chandorkar, Qiao Zhan, Julie Donovan, Shruta Rege and Hernando Patino

    BMC Pharmacology and Toxicology 2017 18:24

    Published on: 28 March 2017

  21. Case report

    Methimazole associated eosinophilic pleural effusion: a case report

    Adverse reactions associated to anti-thyroid drugs include fever, rash, arthralgia, agranulocytosis and hepatitis that are thought to be hypersensitivity reactions. Five cases of pleural effusion associated to...

    Pedro Gaspar-da-Costa, Filipa Duarte Silva, Júlia Henriques, Sónia do Vale, Sandra Braz, João Meneses Santos and Rui M.M. Victorino

    BMC Pharmacology and Toxicology 2017 18:16

    Published on: 21 March 2017

  24. Research article

    Long-term treatment of clarithromycin at a low concentration improves hydrogen peroxide-induced oxidant/antioxidant imbalance in human small airway epithelial cells by increasing Nrf2 mRNA expression

    Clarithromycin (CAM), a representative macrolide antibiotic, has been used widely at low doses for long-term therapy of chronic inflammatory airway diseases. Anti-inflammatory effects of macrolide antibiotics ...

    Kuninori Iwayama, Ayuko Kusakabe, Keisuke Ohtsu, Takahiro Nawano, Ryosuke Tatsunami, Ko-ichi Ohtaki, Yoshiko Tampo and Nobumasa Hayase

    BMC Pharmacology and Toxicology 2017 18:15

    Published on: 25 February 2017

  25. Research article

    Regulation of voltage-gated potassium channels attenuates resistance of side-population cells to gefitinib in the human lung cancer cell line NCI-H460

    Side-population (SP) cells that exclude anti-cancer drugs have been found in various tumor cell lines. Moreover, SP cells have a higher proliferative potential and drug resistance than main population cells (N...

    Seon Young Choi, Hang-Rae Kim, Pan Dong Ryu and So Yeong Lee

    BMC Pharmacology and Toxicology 2017 18:14

    Published on: 21 February 2017

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