Skip to content

Advertisement

You're viewing the new version of our site. Please leave us feedback.

Learn more

BMC Pharmacology and Toxicology

Articles

Sort by
Previous Page Page 2 of 27 Next Page
  1. Content type: Research article

    E2HSA is a genetic fusion protein that consists of two tandem exendin-4 molecules that are covalently bonded to recombinant human serum albumin via a peptide linker. Previous studies have demonstrated that E2H...

    Authors: Caina Li, Shaocong Hou, Shuainan Liu, Yi Huan, Sujuan Sun, Quan Liu and Zhufang Shen

    Citation: BMC Pharmacology and Toxicology 2017 18:48

    Published on:

  2. Content type: Research article

    The COP9 signalosome (CSN) is a conserved protein complex composed of 8 subunits designated CSN1-CSN8. CSN3 represents the third subunit of the CSN and maintains the integrity of the complex. CSN3 binds to the...

    Authors: Mariam A. Ba, Jeffrey Surina, Cherie A. Singer and Maria L. Valencik

    Citation: BMC Pharmacology and Toxicology 2017 18:47

    Published on:

  3. Content type: Research article

    Environmental chemical-induced perturbations of gut microbiome are associated with a series of adverse health outcomes. The effects of triclosan on human health have been controversial in recent years. The pur...

    Authors: Bei Gao, Pengcheng Tu, Xiaoming Bian, Liang Chi, Hongyu Ru and Kun Lu

    Citation: BMC Pharmacology and Toxicology 2017 18:46

    Published on:

  4. Content type: Research article

    Increased pain sensitivity is a putative risk factor for chronic pain and consequently for analgesic use. Conversely, analgesic use may be a cause of increased pain sensitivity, e.g., through opioid-induced hy...

    Authors: Per-Jostein Samuelsen, Christopher Sivert Nielsen, Tom Wilsgaard, Audun Stubhaug, Kristian Svendsen and Anne Elise Eggen

    Citation: BMC Pharmacology and Toxicology 2017 18:45

    Published on:

  5. Content type: Research article

    The expanded use of multiple drugs has increased the occurrence of adverse drug reactions (ADRs) induced by drug-drug interactions (DDIs). However, such reactions are typically not observed in clinical drug-de...

    Authors: Ruifeng Liu, Mohamed Diwan M. AbdulHameed, Kamal Kumar, Xueping Yu, Anders Wallqvist and Jaques Reifman

    Citation: BMC Pharmacology and Toxicology 2017 18:44

    Published on:

  6. Content type: Research article

    Fabry disease (FD) is an X-linked lysosomal storage disorder resulting from the α-galactosidase A gene mutations. Enzyme-replacement-therapy (ERT) products for FD currently used include agalsidase alfa and aga...

    Authors: Kazuya Tsuboi and Hiroshi Yamamoto

    Citation: BMC Pharmacology and Toxicology 2017 18:43

    Published on:

  7. Content type: Research article

    Exposure to chemicals might be toxic to the developing brain. There is a need for simple and robust in vitro cellular models for evaluation of chemical-induced neurotoxicity as a complement to traditional stud...

    Authors: Dina Popova, Jessica Karlsson and Stig O. P. Jacobsson

    Citation: BMC Pharmacology and Toxicology 2017 18:42

    Published on:

  8. Content type: Case report

    Tardive akathisia (TA) is a subtype of tardive syndrome, and its etiology is still uncertain. Sevikar is an anti-hypertensive agent containing both amlodipine and olmesartan, and has never been reported to hav...

    Authors: Men-Ting Hsieh, Pao-Yen Lin, Chia-Jen Tsai, Chiung-Chih Chang and Yu Lee

    Citation: BMC Pharmacology and Toxicology 2017 18:41

    Published on:

  9. Content type: Research article

    Protein ubiquitylation is an important post-translational regulation, which has been shown to be necessary for life cycle progression and survival of Plasmodium falciparum. Ubiquitin is a highly conserved 76 amin...

    Authors: Jagrati Jain, Surendra K. Jain, Larry A. Walker and Babu L. Tekwani

    Citation: BMC Pharmacology and Toxicology 2017 18:40

    Published on:

  10. Content type: Research article

    Metformin associated lactic acidosis (MALA) is a rare but lethal complication. There is no consensus regarding when to stop and resume metformin in patients who undergo coronary artery bypass grafting (CABG). ...

    Authors: Rakan I. Nazer and Khalid A. Alburikan

    Citation: BMC Pharmacology and Toxicology 2017 18:38

    Published on:

  11. Content type: Research article

    We recently reported that hesperetin-5,7,3’-O-triacetate (HTA) dually inhibited phosphodiesterase (PDE)3/4 with a therapeutic ratio of 20.8. The application and development of PDE4 inhibitors for treating asthma ...

    Authors: You-Lan Yang, Chi-Li Chen, Chi-Ming Chen and Wun-Chang Ko

    Citation: BMC Pharmacology and Toxicology 2017 18:39

    Published on:

  12. Content type: Research article

    Psychotropic drugs are common among old people with dementia, and have been associated with increased mortality. Previous studies have not investigated sex differences in this risk. This study was conducted to...

    Authors: Jon Brännström, Gustaf Boström, Erik Rosendahl, Peter Nordström, Håkan Littbrand, Hugo Lövheim and Yngve Gustafson

    Citation: BMC Pharmacology and Toxicology 2017 18:36

    Published on:

  13. Content type: Case report

    Run Rat® is a rodenticide widely used against small mammals. It comprises of a minimum of 32% zinc phosphide which is highly toxic in acute exposures to humans. It may be consumed accidentally or intentionally...

    Authors: Nilukshana Yogendranathan, H. M. M. T. B. Herath, Thenuka Sivasundaram, R. Constantine and Aruna Kulatunga

    Citation: BMC Pharmacology and Toxicology 2017 18:37

    Published on:

  14. Content type: Research article

    Drug-resistant microorganism are a growing global danger. Strains of S. aureus have developed resistance to many commonly used antimicrobials due to indiscriminate use of antimicrobials, and treatment becoming a ...

    Authors: Serawit Deyno, Alemayehu Toma, Mesfin Worku and Muluken Bekele

    Citation: BMC Pharmacology and Toxicology 2017 18:35

    Published on:

  15. Content type: Research article

    Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) such as gefitinib can provide better efficacy and prolonged progression free survival (PFS) than cytotoxic chemotherapy for metastatic lung ...

    Authors: Chih-Jen Yang, Jen-Yu Hung, Ming-Ju Tsai, Kuan-Li Wu, Ta-Chih Liu, Shah-Hwa Chou, Jui-Ying Lee, Jui-Sheng Hsu, Ming-Shyan Huang and Inn-Wen Chong

    Citation: BMC Pharmacology and Toxicology 2017 18:21

    Published on:

  16. Content type: Research article

    The aim of this study is to identify the distribution by municipalities of adverse drug events (ADE) in Portugal, including adverse drug reactions (ADR) and accidental poisoning by drugs (AP), on municipality/...

    Authors: Gianina Scripcaru, Ceu Mateus and Carla Nunes

    Citation: BMC Pharmacology and Toxicology 2017 18:34

    Published on:

  17. Content type: Research article

    Diacetyl-liensinine is a chemosynthetic derivative of liensinine, extracted from the seed embryo of Nelumbo nucifera Gaertn, in China. It has been found to have extensive anti- arrhythmic actions. The present stu...

    Authors: Feng Cao, Teng Wang, Wenmao Ding, Zhe Li, Shaobo Shi and Xiaozhan Wang

    Citation: BMC Pharmacology and Toxicology 2017 18:33

    Published on:

  18. Content type: Research article

    Drug interactions between antiretroviral drugs (ARVs) and anthelminthic drugs, ivermectin (IVM) and praziquantel (PZQ) were assessed by investigating their permeation through the Caco-2 cell monolayers in a tr...

    Authors: Gabriel Kigen and Geoffrey Edwards

    Citation: BMC Pharmacology and Toxicology 2017 18:20

    Published on:

  19. Content type: Research article

    Cardol is a major bioactive constituent in the Trigona incisa propolis from Indonesia, with a strong in vitro antiproliferative activity against the SW620 colorectal adenocarcinoma cell line (IC50 of 4.51 ± 0.76 ...

    Authors: Paula Mariana Kustiawan, Kriengsak Lirdprapamongkol, Tanapat Palaga, Songchan Puthong, Preecha Phuwapraisirisan, Jisnuson Svasti and Chanpen Chanchao

    Citation: BMC Pharmacology and Toxicology 2017 18:32

    Published on:

  20. Content type: Research article

    Poor drug quality is a matter of serious concern, especially in countries where drug regulation and law enforcement are constrained by limited resources. This study was carried out to investigate the cause of ...

    Authors: Mohammad Sofiqur Rahman, Naoko Yoshida, Hirohito Tsuboi, Tep Keila, Tey Sovannarith, Heng Bun Kiet, Eav Dararth, Theingi Zin, Tsuyoshi Tanimoto and Kazuko Kimura

    Citation: BMC Pharmacology and Toxicology 2017 18:31

    Published on:

  21. Content type: Research article

    Promiscuity in molecular interactions between small-molecules, including drugs, and proteins is widespread. Such unintended interactions can be exploited to suggest drug repurposing possibilities as well as to...

    Authors: Matthieu Chartier, Louis-Philippe Morency, María Inés Zylber and Rafael J. Najmanovich

    Citation: BMC Pharmacology and Toxicology 2017 18:18

    Published on:

  22. Content type: Research article

    Vascular disease is a common and often severe complication in diabetes mellitus. Hyperglycemia and hypertension are considered to be two of the leading risk factors for vascular complications in diabetic patie...

    Authors: Yu-Guang Ma, Jun-Wei Wang, Yun-Gang Bai, Mei Liu, Man-Jiang Xie and Zhi-Jun Dai

    Citation: BMC Pharmacology and Toxicology 2017 18:30

    Published on:

  23. Content type: Research article

    The present study was designed to investigate the protective effect of aqueous date extract (ADE) against the dichloroacetic acid (DCA)-induced testicular injury in rats.

    Authors: Amira El Arem, Lamia Lahouar, Emna Behija Saafi, Amira Thouri, Fatma Ghrairi, Zohra Houas, Fadoua Neffati and Lotfi Achour

    Citation: BMC Pharmacology and Toxicology 2017 18:17

    Published on:

  24. Content type: Research article

    The objective of the present study aimed to investigate the effect of CoQ10 treatment on isoprenaline (ISO)-induced cardiac remodeling in rats.

    Authors: Anayt Ulla, Mustafe Khalid Mohamed, Biswajit Sikder, AFM Towheedur Rahman, Farzana Akther Sumi, Murad Hossain, Hasan Mahmud Reza, G. M. Sayedur Rahman and Md Ashraful Alam

    Citation: BMC Pharmacology and Toxicology 2017 18:29

    Published on:

  25. Content type: Research article

    Nowadays, canagliflozin monotherapy, or in combination with other oral hypoglycemic agents (OHAs), is often administered in patients who are treated for type 2 diabetes mellitus (T2DM). Therefore, we aimed to ...

    Authors: Pravesh Kumar Bundhun, Girish Janoo and Feng Huang

    Citation: BMC Pharmacology and Toxicology 2017 18:19

    Published on:

Previous Page Page 2 of 27 Next Page
Reviewer acknowledgments