Volume 14 Supplement 1

6th International Conference on cGMP: Generators, Effectors and Therapeutic Implications

Meeting abstracts

Edited by John C Burnett Jr, Franz Hofmann, Kazuwa Nakao, Harald HHW Schmidt and Johannes-Peter Stasch

Publication of this supplement has been fully funded by Bayer Pharma AG. Johannes-Peter Stasch is an employee of Bayer Pharma AG, Wuppertal, Germany. He holds many patents on sGC stimulators and sGC activators. John C Burnett Jr is the chairman of the advisory board for Nile Therapeutics and is a Co-Founder and the Chief Scientific Officer for Zumbro Discovery. Mayo Clinic has licensed CD-NP to Nile Therapeutics and MANP to Zumbro Discovery. The other Supplement Editors declare that they have no competing interests.

6th International Conference on cGMP: Generators, Effectors and Therapeutic Implications. Go to conference site.

Erfurt, Germany28-30 June 2013

Page 2 of 3

cGMP-dependent protein kinase Iβ phosphorylates and regulates the function of the actin/myosin-associatedprotein caldesmon

Authors: Darren E Casteel, Raphaela Schwappacher, Hema Rangaswami and Jacqueline Su-Yuo

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P13

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Receptor guanylyl cyclase-G is a novel thermosensor in Grueneberg ganglion neurons involved in coolness-induced ultrasonic distress calls in mice

Authors: Ying-Chi Chao, Heinz Breer, Yuh-Charn Lin, Chih-Cheng Chen, Joerg Fleischer and Ruey-Bing Yang

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P14

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Synthesis and evaluation of bifunctional sGC regulators

Authors: Mikolaj Chrominski, Dorota Gryko, Iraida Sharina and Emil Martin

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P15

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A tissue based chemical proteomics screen to identify novel G-kinase associated proteins (GKAPs)

Authors: Eleonora Corradini, Pepijn P Burgers, Michael Plank, Albert JR Heck and Arjen Scholten

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P16

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Defining the molecular targets of cerebellar PKG by quantitative (phospho)proteomics in a knock-out mouse model

Authors: Eleonora Corradini, Robert Feil, Albert JR Heck and Arjen Scholten

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P17

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The soluble guanylyl cyclase activator BAY 60-2770 ameliorates detrusor dysfunction in obese mice

Authors: Gilberto de Nucci, Luiz Osorio Leiria, Fábio Henrique da Silva, Eduardo C Alexandre, Marina Calixto, Fabíola Zakia Mónica and Edson Antunes

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P18

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A novel role of the natriuretic peptide/cGMP/cGKI pathway in melanoma cells

Authors: Sandeep Dhayade, Susanne Feil, Christoph Griessinger, Manfred Kneilling, Birgit Schittek and Robert Feil

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P19

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The soluble guanylyl cyclase stimulator BAY 41-2272 increases differentiation and function of brown adipocytes

Authors: Jennifer Etzrodt, Linda S Hoffmann, Andreas Friebe and Alexander Pfeifer

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P20

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Pharmacokinetics of the soluble guanylate cyclase stimulator riociguat in individuals with hepatic impairment

Authors: Reiner Frey, Corina Becker, Sigrun Unger, Anja Schmidt, Georg Wensing and Wolfgang Mueck

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P21

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Pharmacokinetics of the soluble guanylate cyclase stimulator riociguat in individuals with renal impairment

Authors: Reiner Frey, Corina Becker, Sigrun Unger, Anja Schmidt, Georg Wensing and Wolfgang Mueck

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P22

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Effects of age and gender on the pharmacokinetics of the soluble guanylate cyclase stimulator riociguat

Authors: Reiner Frey, John Lettieri, Andrea Nadel, Corina Becker and Wolfgang Mück

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P23

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Guanylyl cyclase-B plays an important role in adipogenesis and “browning” of white fat

Authors: Anja Glöde, Ana Kilić, John C Burnett and Alexander Pfeifer

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P24

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Soluble guanylyl cyclase as a therapeutic target in chronic obstructive pulmonary disease (COPD)

Authors: Constantinos Glynos, Dimitris Toumpanakis, Zongmin Zhou, Peter Brouckaert, Theodoros Vassilakopoulos and Andreas Papapetropoulos

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P25

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PDE3 is the major cGMP-PDE in adult mouse ventricular cardiomyocytes

Authors: Konrad R Götz and Viacheslav O Nikolaev

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P26

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Cardiovascular response to NO donors in mice deficient in NO-GC

Authors: Dieter Groneberg, Anna Schlembach and Andreas Friebe

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P27

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The role of VASP in cGMP-mediated vascular smooth muscle relaxation

Authors: Staffan Hildebrand, Katrin Zimmermann, Daniela Wenzel, Bernd K Fleischmann and Alexander Pfeifer

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P28

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Urinary cGMP concentrations after exposure to radio-contrast media in patient at risk for contrast media induced nephropathy (CIN) predicts 90-day morbidity and mortality

Authors: Berthold Hocher, Fabian Heunisch, Gina-Franziska von Einem, Markus Alter, Yvonne Keim and Johannes-Peter Stasch

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P29

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Chronic activation of heme free soluble guanylate cyclase leads to cardio-renal protection in experimental hypertension

Authors: Linda S Hoffmann, Axel Kretschmer, Bettina Lawrenz, Andreas Hucke, Berthold Hocher and Johannes-Peter Stasch

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P30

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Cyclic GMP-mediated intercellular communication in mammalian ovarian follicles

Authors: Laurinda A Jaffe, Jeremy R Egbert, Leia C Shuhaibar, Lai Wen, Martin Thunemann, Robert Feil, Viacheslav Nikolaev, Jerid W Robinson and Lincoln R Potter

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P31

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Phosphodiesterase 5 is main regulator of brown adipocyte differentiation

Authors: Ana Kilić, Thorsten Gnad, Linda S Hoffmann and Alexander Pfeifer

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P32

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Crystal structures of the carboxyl cGMP binding domain of plasmodium falciparumcGMP-dependent protein kinase reveals a novel salt bridge crucial for activation

Authors: Jeong Joo Kim, Eduardo Sanabria Figueroa, Eugen Franz, Daniela Bertinetti, Friedrich Herberg and Choel Kim

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P33

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Interstitial cells of Cajal plasticity rather than regeneration restores slow-wave activity and enteric neurotransmission upon acute damage

Authors: Sabine Klein, Barbara Seidler, Anna Kettenberger, Andrei Sibaev, Robert Feil, Franz Hofmann, Jean-Marie Vanderwinden, Hans-Dieter Allescher, Michael Schemann, Martin A Storr, Roland M Schmid, Günter Schneider and Dieter Saur

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P34

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A bone overgrowth disorder due to a gain-of-function mutation in the kinase homology domain of guanylyl cyclase B, the receptor for CNP

Authors: Michaela Kuhn, Thomas Premsler, Ruey-Bing Yang, Thomas D Mueller, Birgit Gaßner, Heike Oberwinkler, Sabine E Hannema, Hermine A van Duyvenvoorde, Ferdinand Roelfsema, Gijs WE Santen, Timothy Prickett, Sarina G Kant, Annemieke JMH Verkerk, André G Uitterlinden, Eric Espiner, Claudia AL Ruivenkamp…

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P35

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Increases survival by apo-sGC activation via post-stroke blood brain barrier stabilisation and anti-inflammation

Authors: Friedericke Langhauser, Annegret Hauck, Kim Radermacher, Johannes-Peter Stasch, Christoph Kleinschnitz and Harald HHW Schmidt

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P36

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Localization and function of NO-GC in the murine gastrointestinal and lower urinary tract

Authors: Barbara Lies, Dieter Groneberg, Dieter Saur and Andreas Friebe

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P37

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A biodegradable in-situ polymer precipitation delivery system for sustained delivery of a novel chimeric natriuretic peptide CD-NP in an experimental model of myocardial infarction

Authors: Soo Ghim Lim, S Jeson Sangaralingham, Syed Ameenuddin, Fernando L Martin, Xu Wen Ng, Ying Ying Huang, Subbu S Venkatraman, John C Burnett Jr and Horng H Chen

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P38

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Metabolic fate of orally administered cGMP in rats

Authors: Elaine Liong, Christopher Graul, Samuel Rivers, Marco Kessler, Gerhard Hannig and Inmaculada Silos-Santiago

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P39

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Evidence for functional coupling of cGMP/cGKI signalling and TRPC channels in endothelium but not in vascular smooth muscle

Authors: Florian Loga, Katrin Domes, Marc Freichel, Veit Flockerzi, Alexander Dietrich, Lutz Birnbaumer, Franz Hofmann and Jörg W Wegener

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P40

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Transforming PKA into PKG – a structure-function approach to understand cyclic nucleotide selectivity

Authors: Robin Lorenz, Eui-Whan Moon, Gilbert Y Huang, Albert S Reger, Jeong J Kim, Eugen Franz, Daniela Bertinetti, Choel Kim and Friedrich W Herberg

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P41

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Alternative splicing of α1 and β1 sGC genes is altered in aortic disease

Authors: Emil Martin, Eva Golunski and Iraida Sharina

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P42

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M-atrial natriuretic peptide and nitroglycerin in experimental acute hypertensive heart failure: differential actions of two cGMP activating therapeutics

Authors: Paul M McKie, Alessandro Cataliotti, Tomoko Ichiki, S Jeson Sangaralingham, Horng H Chen and John C Burnett Jr

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P43

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Video microscopy as a tool to visualize cGMP effects on contractility and sperm transport in seminiferous tubules and the epididymal duct

Authors: Andrea Mietens, Gerrit Eichner, Sabine Tasch, Caroline Feuerstacke, Ingrid Schneider-Hüther, Dieter Müller and Ralf Middendorff

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P44

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Endothelial dysfunction in adipose triglyceride lipase deficiency: role of perivascular adipose tissue

Authors: Marion Mussbacher, Karoline Pail, Gerald Wölkart, Günter Hämmerle, Alois Lametschwandtner, Rudolf Zechner, Bernd Mayer and Astrid Schrammel

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P45

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The good and the ugly: ANP antagonizes the deleterious effects of aldosterone in hypertensive cardiac remodeling

Authors: Hitoshi Nakagawa, Katharina Völker, Heike Oberwinkler, Birgit Gaßner, Charlotte Dienesch, Sandra Umbenhauer, Hideo A Baba, Stefan Frantz and Michaela Kuhn

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P46

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The effects of super-flux (high performance) dialyzer on the plasma glycosylated pro-B-type natriuretic peptide (proBNP) and glycosylated N-terminal proBNP in end-stage renal disease patients on dialysis

Authors: Yasuaki Nakagawa, Toshio Nishikimi, Naoto Minamino, Chinatsu Yamada, Kazuhiro Nakao, Takeya Minami, Yoshihiro Kuwabara, Hideyuki Kinoshita, Shinji Yasuno, Kenji Ueshima, Koichiro Kuwahara, Kenji Kangawa and Kazuwa Nakao

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P47

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Impact of local CNP/GC-B system in growth plates on endochondral bone growth

Authors: Kazumasa Nakao, Akihiro Yasoda, Kenji Osawa, Toshihito Fujii, Eri Kondo, Noriaki Koyama, Naotetsu Kanamoto, Masako Miura, Koichiro Kuwahara, Haruhiko Akiyama, Kazuhisa Bessho and Kazuwa Nakao

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P48

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Potent inhibition of nitroglycerin bioactivation by diphenyleneiodonium (DIP)

Authors: Regina Neubauer, Andrea Neubauer, Gerald Wölkart, Christine Schwarzenegger, Barbara Lang, Kurt Schmidt, Michael Russwurm, Doris Koesling, Antonius CF Gorren, Astrid Schrammel and Bernd Mayer

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P49

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O-glycosylated pro-B-type natriuretic peptide is cleaved intracellularly by furin in ventricular and atrial myocytes: importance of the distance between the O-glycosylation and cleavage sites

Authors: Toshio Nishikimi, Yasuaki Nakagawa, Naoto Minamino, Masashi Ikeda, Toshihiko Ishimitsu, Chinatsu Yamada, Kazuhiro Nakao, Takeya Minami, Yoshihiro Kuwabara, Hideyuki Kinoshita, Koichiro Kuwahara, Kenji Kangawa and Kazuwa Nakao

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P50

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ANP/GC-A signaling attenuates tissue injury by cisplatin

Authors: Takashi Nojiri, Hiroshi Hosoda, Toru Kimura and Kenji Kangawa

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P51

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ANP/GC-A signaling attenuates pulmonary metastasis of B16 melanoma enhanced by lipopolysaccharide or angiotensin-II

Authors: Takashi Nojiri, Hiroshi Hosoda, Shin Ishikane, Toru Kimura and Kenji Kangawa

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P52

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Protective role of endogenous cardiac natriuretic peptide/GC-A system on the maternal heart during the postpartum period

Authors: Kentaro Otani, Takeshi Tokudome, Ichiro Kishimoto, Yuanjie Mao, Kenichi Yamahara, Kazuwa Nakao and Kenji Kangawa

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P53

Content type: Poster presentation Published on: 29 August 2013
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Determination of cGMP levels in rodent tissues following oral dosing of a soluble guanylate cyclase stimulator

Authors: Nisha Perez, Christopher Graul, Peter Germano, Erik Solberg, Samuel Rivers, Robert Solinga, Joel Moore, Gerhard Hannig, Ada Silos-Santiago, Robert Busby and Daniel Zimmer

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P54

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Platelet inhibitory effects of the NO independent sGC stimulator riociguat (Bay 63-2561)

Authors: Cora Reiss, Igor Mindukshev, Verena Bischoff, Stepan Gambaryan and Ulrich Walter

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P55

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The nitroxyl donor isopropylamine-NONOate elicits soluble guanylyl cyclase-dependent antihypertrophic actions: comparison of the potential therapeutic advantages of HNO over NO•

Authors: Rebecca Ritchie, Jennifer Irvine, Nga Cao, Swati Gossain, Amy Alexander, Jane Love, Chengxue Qin, John D Horowitz and Barbara K Kemp-Harper

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P56

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Soluble guanylyl cyclase mediates concomitant coronary vasodilator and positive inotropic actions of the HNO donor Angeli's salt in the intact rat heart

Authors: Rebecca Ritchie, Kai Yee Chin, Chengxue Qin, Nga Cao, Barbara Kemp-Harper and Owen Woodman

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P57

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Protein kinase G oxidation contribute to hypotension and organ injury during sepsis

Authors: Olena Rudyk, Alkystis Phinikaridou, Oleksandra Prysyazhna, Joseph R Burgoyne, Rene Botnar and Philip Eaton

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P58

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In striatum phosphodiesterase 10A is part of a synaptic signalling complex

Authors: Corina Russwurm, Doris Koesling and Michael Russwurm

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P59

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Influence of PKG on insulin signalling and GSK3 phosphorylation in SH-SY5Y cells

Authors: Abhishek Sanyal, Didier Lochmatter, Anne Preußner and Alexander Pfeifer

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P60

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Suppression of kidney fibrosis by cGMP-dependent protein kinase I

Authors: Elisabeth Schinner, Andrea Schramm, Frieder Kees, Franz Hofmann and Jens Schlossmann

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P61

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Fishing for elusive cCMP-degrading phosphodiesterases

Authors: Erich Schneider, Maike Kuhn, Daniel Reinecke, Sabine Wolter, Heike Burhenne, Volkhard Kaever and Roland Seifert

Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P62

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6th International Conference on cGMP: Generators, Effectors and Therapeutic Implications

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