Articles
Page 6 of 25
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Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P3
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Pharmacokinetic interaction of ketoconazole, clarithromycin, and midazolam with riociguat
Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P5 -
Genetic variants of ANP and cardiometabolic protection: from populations to novel therapeutics
Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O7 -
Absorption behavior of riociguat: bioavailability, food effects, and dose-proportionality
Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P7 -
NO-cGMP signalling and cancer therapy
Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P9 -
MicroRNA miR-425 is a negative regulator of atrial natriuretic peptide
Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O10 -
Soluble guanylate cyclase crystal clear: 1stcrystal structure of the wild-type human heterodimeric sGC catalytic domains and implications for activity
Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O14 -
Structures of human PKG reveal cGMP-selectived activation mechanisms
Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O16 -
Pharmacokinetics of the soluble guanylate cyclase stimulator riociguat in individuals with renal impairment
Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P22 -
Chronic beta-adrenergic blockade prevents volume overload-induced re-localization and oxidation of soluble guanylyl cyclase
Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O22 -
Non-genomic thyroid hormone signaling through NO/cGMP/PKGII
Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O26 -
Chronic activation of heme free soluble guanylate cyclase leads to cardio-renal protection in experimental hypertension
Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P30 -
Interstitial cells of Cajal link excitatory and nitrergic inhibitory neurotransmission with slow-wave activity in the intestine
Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O30 -
Interstitial cells of Cajal plasticity rather than regeneration restores slow-wave activity and enteric neurotransmission upon acute damage
Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P34 -
Pseudomonas aeruginosaExoY, a cyclic GMP- and cyclic UMP-generating nucleotidyl cyclase
Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):O36 -
Alternative splicing of α1 and β1 sGC genes is altered in aortic disease
Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P42 -
Video microscopy as a tool to visualize cGMP effects on contractility and sperm transport in seminiferous tubules and the epididymal duct
Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P44 -
Potent inhibition of nitroglycerin bioactivation by diphenyleneiodonium (DIP)
Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P49 -
Genes involved in pulmonary hypertension of mice with endothelial-specific ablation of guanylyl cyclase A
Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P77 -
Activation profile of cGMP-dependent protein kinase Iα
Citation: BMC Pharmacology and Toxicology 2013 14(Suppl 1):P79 -
An interview with David H Farb, Section Editor for Basic Pharmacology
Citation: BMC Pharmacology and Toxicology 2013 14:42 -
Tocopheryl acetate 20% spray for elimination of head louse infestation: a randomised controlled trial comparing with 1% permethrin creme rinse
Tocopheryl acetate is viscous oily fluid used in a range of preparations for skin and scalp care in Italy. Observational and in vitro data have suggested a high level of efficacy against head louse infestation. T...
Citation: BMC Pharmacology and Toxicology 2013 14:43 -
Active post-marketing surveillance of the intralesional administration of human recombinant epidermal growth factor in diabetic foot ulcers
After several exploratory and confirmatory clinical trials, the intralesional administration of human recombinant epidermal growth factor (hrEGF) has been approved for the treatment of advanced diabetic foot u...
Citation: BMC Pharmacology and Toxicology 2013 14:44 -
Tissue concentration of paraquat on day 32 after intoxication and failed bridge to transplantation by extracorporeal membrane oxygenation therapy
Paraquat is a highly toxic herbicide, which not only leads to acute organ damage, but also to pulmonary fibrosis. There are only anecdotal reports of rescue lung transplantation, as paraquat is stored and only...
Citation: BMC Pharmacology and Toxicology 2013 14:45 -
Assessing the translatability of In vivo cardiotoxicity mechanisms to In vitro models using causal reasoning
Drug-induced cardiac toxicity has been implicated in 31% of drug withdrawals in the USA. The fact that the risk for cardiac-related adverse events goes undetected in preclinical studies for so many drugs under...
Citation: BMC Pharmacology and Toxicology 2013 14:46 -
Raltegravir does not revert efflux activity of MDR1-P-glycoprotein in human MDR cells
Raltegravir (Isentress®)(RALT) has demonstrated excellent efficacy in both treatment-experienced and naïve patients with HIV-1 infection, and is the first strand transfer integrase inhibitor to be approved for...
Citation: BMC Pharmacology and Toxicology 2013 14:47 -
The favorable kinetics and balance of nebivolol-stimulated nitric oxide and peroxynitrite release in human endothelial cells
Nebivolol is a third-generation beta-blocker used to treat hypertension. The vasodilation properties of nebivolol have been attributed to nitric oxide (NO) release. However, the kinetics and mechanism of nebiv...
Citation: BMC Pharmacology and Toxicology 2013 14:48 -
The current status and trend of clinical pharmacology in developing countries
Several international forums for promoting clinical pharmacology in developing countries have been held since 1980, and several clinical pharmacology programmes targeting developing countries were instituted s...
Citation: BMC Pharmacology and Toxicology 2013 14:49 -
Pharmacokinetics and biodistribution of the cyclin-dependent kinase inhibitor -CR8- in mice
CR8 is a second generation inhibitor of cyclin-dependent kinases derived from roscovitine. CR8 was shown to be 50–100 fold more potent than roscovitine in inducing apoptosis in different tumor cell lines. In t...
Citation: BMC Pharmacology and Toxicology 2013 14:50 -
Translational toxicology: a developmental focus for integrated research strategies
Given that toxicology studies the potential adverse effects of environmental exposures on various forms of life and that clinical toxicology typically focuses on human health effects, what can and should the r...
Citation: BMC Pharmacology and Toxicology 2013 14:51 -
Physiological and pharmacokinetic effects of oral 1,3-dimethylamylamine administration in men
1,3-dimethylamylamine (DMAA) has been a component of dietary supplements and is also used within "party pills," often in conjunction with alcohol and other drugs. Ingestion of higher than recommended doses res...
Citation: BMC Pharmacology and Toxicology 2013 14:52 -
Lean body mass: the development and validation of prediction equations in healthy adults
There is a loss of lean body mass (LBM) with increasing age. A low LBM has been associated with increased adverse effects from prescribed medications such as chemotherapy. Accurate assessment of LBM may allow ...
Citation: BMC Pharmacology and Toxicology 2013 14:53 -
Dipyrithione induces cell-cycle arrest and apoptosis in four cancer cell lines in vitro and inhibits tumor growth in a mouse model
Dipyrithione (PTS2) is widely used as a bactericide and fungicide. Here, we investigated whether PTS2 has broad-spectrum antitumor activity by studying its cytotoxicity and proapoptotic effects in four cancer ...
Citation: BMC Pharmacology and Toxicology 2013 14:54 -
Prescription of antiviral drugs during the 2009 influenza pandemic: an observational study using electronic medical files of general practitioners in the Netherlands
After the clinical impact of the A(H1N1) pdm09 virus was considered to be mild, treatment with antiviral drugs was recommended only to patients who were at risk for severe disease or who had a complicated cour...
Citation: BMC Pharmacology and Toxicology 2013 14:55 -
Psychotropic drug use among people with dementia – a six-month follow-up study
Psychotropic drugs are widely used among old people with dementia but few studies have described long-term treatment in this group of patients. The purpose of this study was to explore the long-term use of psy...
Citation: BMC Pharmacology and Toxicology 2013 14:56 -
The association between statin therapy during intensive care unit stay and the incidence of venous thromboembolism: a propensity score-adjusted analysis
Studies have shown that statins have pleiotropic effects on inflammation and coagulation; which may affect the risk of developing venous thromboembolism (VTE). The objective of this study was to evaluate the a...
Citation: BMC Pharmacology and Toxicology 2013 14:57 -
Suppression of eukaryotic initiation factor 4E prevents chemotherapy-induced alopecia
Chemotherapy-induced hair loss (alopecia) (CIA) is one of the most feared side effects of chemotherapy among cancer patients. There is currently no pharmacological approach to minimize CIA, although one strate...
Citation: BMC Pharmacology and Toxicology 2013 14:58 -
Pharmacokinetics of piperacillin/tazobactam in cancer patients with hematological malignancies and febrile neutropenia after chemotherapy
Patients with febrile neutropenia (FN) exhibit changes in extracellular fluid that may alter the plasma concentrations of beta-lactams and result in therapeutic failure or toxicity. We evaluated the pharmacoki...
Citation: BMC Pharmacology and Toxicology 2013 14:59 -
Indoxyl sulfate promotes apoptosis in cultured osteoblast cells
Indoxyl sulfate (IS), an organic anion uremic toxin, promotes the progression of renal dysfunction. Some studies have suggested that IS inhibits osteoclast differentiation and suppresses parathyroid hormone (P...
Citation: BMC Pharmacology and Toxicology 2013 14:60 -
Bilateral brachial plexus injury following acute carbon monoxide poisoning
Carbon monoxide (CO) intoxication is a leading cause of severe neuropsychological impairments. Peripheral nerve injury has rarely been reported. It consists usually in a demyelinating polyneuropathy or mononeu...
Citation: BMC Pharmacology and Toxicology 2013 14:61 -
Ecotoxicology inside the gut: impact of heavy metals on the mouse microbiome
The gut microbiota is critical for intestinal homeostasis. Recent studies have revealed the links between different types of dysbiosis and diseases inside and outside the intestine. Environmental exposure to p...
Citation: BMC Pharmacology and Toxicology 2013 14:62 -
Hypersensitivity to oxaliplatin: clinical features and risk factors
Oxaliplatin-based regimens induce a potential risk of hypersensitivity reaction (HSR), with incidence varying from 10% to 25% and lack of clearly identified risk factors. The present study aimed to assess inci...
Citation: BMC Pharmacology and Toxicology 2014 15:1 -
A Phase 1 dose-ranging study examining the effects of a superabsorbent polymer (CLP) on fluid, sodium and potassium excretion in healthy subjects
CLP is an orally administered, non-absorbed, superabsorbent polymer being developed to increase fecal excretion of sodium, potassium and water in patients with heart failure and end-stage renal disease. This s...
Citation: BMC Pharmacology and Toxicology 2014 15:2 -
Rosacea-like facial rash related to metformin administration in a young woman
Since the skin represents a common site of adverse drug reactions, few data are reported at this time regarding the development of skin rash during the treatment with antidiabetic drugs.
Citation: BMC Pharmacology and Toxicology 2014 15:3 -
Retrospective evaluation of cotrimoxazole use as preventive therapy in people living with HIV/AIDS in Boru Meda Hospital
Drug use evaluation is a performance improvement method that focuses on evaluating and improving drug use process to achieve optimal patient outcomes. Drug use evaluation helps in identifying, preventing or re...
Citation: BMC Pharmacology and Toxicology 2014 15:4 -
Skin sensitizers differentially regulate signaling pathways in MUTZ-3 cells in relation to their individual potency
Due to the recent European legislations posing a ban of animal tests for safety assessment within the cosmetic industry, development of in vitro alternatives for assessment of skin sensitization is highly priorit...
Citation: BMC Pharmacology and Toxicology 2014 15:5 -
Antibiotic sales in rural and urban pharmacies in northern Vietnam: an observational study
The irrational overuse of antibiotics should be minimized as it drives the development of antibiotic resistance, but changing these practices is challenging. A better understanding is needed of practices and e...
Citation: BMC Pharmacology and Toxicology 2014 15:6 -
Preclinical and clinical phase I studies of a new recombinant Filgrastim (BK0023) in comparison with Neupogen®
Filgrastim or methionyl-granulocyte colony-stimulating factor (Met-G-CSF), is a recombinant therapeutic protein widely used to treat severe neutropenia caused by myelosuppressive drugs in patients with nonmyel...
Citation: BMC Pharmacology and Toxicology 2014 15:7 -
An outpatient antibacterial stewardship intervention during the journey to JCI accreditation
Antibacterial overuse, misuse and resistance have become a major global threat. The Joint Commission International (JCI) accreditation standards include quality improvement and patient safety, which is exempli...
Citation: BMC Pharmacology and Toxicology 2014 15:8 -
Modeling of chemical inhibition from amyloid protein aggregation kinetics
The process of amyloid proteins aggregation causes several human neuropathologies. In some cases, e.g. fibrillar deposits of insulin, the problems are generated in the processes of production and purification of ...
Citation: BMC Pharmacology and Toxicology 2014 15:9
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