Global Report: UNAIDS report on the global AIDS epidemic 2010.http://www.unaids.org/globalreport/Global_report.htm,
Ramjee G: Microbicide research: current and future directions. Curr Opin HIV AIDS. 2010, 5 (4): 316-321. 10.1097/COH.0b013e32833a9f66.
Article
PubMed
Google Scholar
Nuttall J: Microbicides in the prevention of HIV infection: current status and future directions. Drugs. 2010, 70 (10): 1231-1243.
CAS
PubMed
Google Scholar
Minces LR, McGowan I: Advances in the Development of Microbicides for the Prevention of HIV Infection. Curr Infect Dis Rep. 2010, 12 (1): 56-62. 10.1007/s11908-009-0076-5.
Article
PubMed
PubMed Central
Google Scholar
Van Damme L, Ramjee G, Alary M, Vuylsteke B, Chandeying V, Rees H, Sirivongrangson P, Mukenge-Tshibaka L, Ettiegne-Traore V, Uaheowitchai C: Effectiveness of COL-1492, a nonoxynol-9 vaginal gel, on HIV-1 transmission in female sex workers: a randomised controlled trial. Lancet. 2002, 360 (9338): 971-977. 10.1016/S0140-6736(02)11079-8.
Article
CAS
PubMed
Google Scholar
Peterson L, Nanda K, Opoku BK, Ampofo WK, Owusu-Amoako M, Boakye AY, Rountree W, Troxler A, Dominik R, Roddy R: SAVVY (C31G) gel for prevention of HIV infection in women: a Phase 3, double-blind, randomized, placebo-controlled trial in Ghana. PLoS One. 2007, 2 (12): e1312-10.1371/journal.pone.0001312.
Article
PubMed
PubMed Central
Google Scholar
Pirrone V, Wigdahl B, Krebs FC: The rise and fall of polyanionic inhibitors of the human immunodeficiency virus type 1. Antiviral Res. 2011, 90 (3): 168-182. 10.1016/j.antiviral.2011.03.176.
Article
CAS
PubMed
Google Scholar
Veazey RS: Microbicide safety/efficacy studies in animals: macaques and small animal models. Curr Opin HIV AIDS. 2008, 3 (5): 567-573. 10.1097/COH.0b013e32830891bb.
Article
PubMed
PubMed Central
Google Scholar
Hillier SL, Moench T, Shattock R, Black R, Reichelderfer P, Veronese F: In vitro and in vivo: the story of nonoxynol 9. J Acquir Immune Defic Syndr. 2005, 39 (1): 1-8. 10.1097/01.qai.0000159671.25950.74.
Article
CAS
PubMed
Google Scholar
Benes S, McCormack WM: Inhibition of growth of Chlamydia trachomatis by nonoxynol-9 in vitro. Antimicrob Agents Chemother. 1985, 27 (5): 724-726. 10.1128/AAC.27.5.724.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kelly JP, Reynolds RB, Stagno S, Louv WC, Alexander WJ: In vitro activity of the spermicide nonoxynol-9 against Chlamydia trachomatis. Antimicrob Agents Chemother. 1985, 27 (5): 760-762. 10.1128/AAC.27.5.760.
Article
CAS
PubMed
PubMed Central
Google Scholar
Asculai SS, Weis MT, Rancourt MW, Kupferberg AB: Inactivation of herpes simplex viruses by nonionic surfactants. Antimicrob Agents Chemother. 1978, 13 (4): 686-690. 10.1128/AAC.13.4.686.
Article
CAS
PubMed
PubMed Central
Google Scholar
Jennings R, Clegg A: The inhibitory effect of spermicidal agents on replication of HSV-2 and HIV-1 in-vitro. J Antimicrob Chemother. 1993, 32 (1): 71-82. 10.1093/jac/32.1.71.
Article
CAS
PubMed
Google Scholar
Malkovsky M, Newell A, Dalgleish AG: Inactivation of HIV by nonoxynol-9. Lancet. 1988, 1 (8586): 645-
Article
CAS
PubMed
Google Scholar
Krebs FC, Miller SR, Malamud D, Howett MK, Wigdahl B: Inactivation of human immunodeficiency virus type 1 by nonoxynol-9, C31G, or an alkyl sulfate, sodium dodecyl sulfate. Antiviral Res. 1999, 43 (3): 157-173. 10.1016/S0166-3542(99)00044-3.
Article
CAS
PubMed
Google Scholar
Polsky B, Baron PA, Gold JW, Smith JL, Jensen RH, Armstrong D: In vitro inactivation of HIV-1 by contraceptive sponge containing nonoxynol-9. Lancet. 1988, 1 (8600): 1456-
Article
CAS
PubMed
Google Scholar
Singh B, Cutler JC, Utidjian HM: Studies on development of a vaginal preparation providing both prophylaxis against venereal disease, other genital infections and contraception. 3. In vitro effect of vaginal contraceptive and selected vaginal preparations of Candida albicans and Trichomonas vaginalis. Contraception. 1972, 5 (5): 401-411. 10.1016/0010-7824(72)90032-7.
Article
CAS
PubMed
Google Scholar
Cook RL, Rosenberg MJ: Do spermicides containing nonoxynol-9 prevent sexually transmitted infections? A meta-analysis. Sex Transm Dis. 1998, 25 (3): 144-150. 10.1097/00007435-199803000-00007.
Article
CAS
PubMed
Google Scholar
Catalone BJ, Kish-Catalone TM, Budgeon LR, Neely EB, Ferguson M, Krebs FC, Howett MK, Labib M, Rando R, Wigdahl B: Mouse model of cervicovaginal toxicity and inflammation for preclinical evaluation of topical vaginal microbicides. Antimicrob Agents Chemother. 2004, 48 (5): 1837-1847. 10.1128/AAC.48.5.1837-1847.2004.
Article
CAS
PubMed
PubMed Central
Google Scholar
Roddy RE, Cordero M, Cordero C, Fortney JA: A dosing study of nonoxynol-9 and genital irritation. Int J STD AIDS. 1993, 4 (3): 165-170.
CAS
PubMed
Google Scholar
Chvapil M, Droegemueller W, Owen JA, Eskelson CD, Betts K: tudies of nonoxynol-9. I. The effect on the vaginas of rabbits and rats. Fertil Steril. 1980, 33 (4): 445-450.
Article
CAS
PubMed
Google Scholar
Kaminsky M, Szivos MM, Brown KR, Willigan DA: Comparison of the sensitivity of the vaginal mucous membranes of the albino rabbit and laboratory rat to nonoxynol-9. Food Chem Toxicol. 1985, 23 (7): 705-708. 10.1016/0278-6915(85)90161-9.
Article
CAS
PubMed
Google Scholar
Catalone BJ, Ferguson ML, Miller SR, Malamud D, Kish-Catalone T, Thakkar NJ, Krebs FC, Howett MK, Wigdahl B: Prolonged exposure to the candidate microbicide C31G differentially reduces cellular sensitivity to agent re-exposure. Biomed Pharmacother. 2005, 59 (8): 460-468. 10.1016/j.biopha.2005.07.009.
Article
CAS
PubMed
Google Scholar
Catalone BJ, Miller SR, Ferguson ML, Malamud D, Kish-Catalone T, Thakkar NJ, Krebs FC, Howett MK, Wigdahl B: Toxicity, inflammation, and anti-human immunodeficiency virus type 1 activity following exposure to chemical moieties of C31G. Biomed Pharmacother. 2005, 59 (8): 430-437. 10.1016/j.biopha.2005.07.008.
Article
CAS
PubMed
Google Scholar
Catalone BJ, Kish-Catalone TM, Neely EB, Budgeon LR, Ferguson ML, Stiller C, Miller SR, Malamud D, Krebs FC, Howett MK: Comparative safety evaluation of the candidate vaginal microbicide C31G. Antimicrob Agents Chemother. 2005, 49 (4): 1509-1520. 10.1128/AAC.49.4.1509-1520.2005.
Article
CAS
PubMed
PubMed Central
Google Scholar
Roddy RE, Cordero M, Ryan KA, Figueroa J: A randomized controlled trial comparing nonoxynol-9 lubricated condoms with silicone lubricated condoms for prophylaxis. Sex Transm Infect. 1998, 74 (2): 116-119. 10.1136/sti.74.2.116.
Article
CAS
PubMed
PubMed Central
Google Scholar
Fichorova RN, Bajpai M, Chandra N, Hsiu JG, Spangler M, Ratnam V, Doncel GF: Interleukin (IL)-1, IL-6, and IL-8 predict mucosal toxicity of vaginal microbicidal contraceptives. Biol Reprod. 2004, 71 (3): 761-769. 10.1095/biolreprod.104.029603.
Article
CAS
PubMed
Google Scholar
Fichorova RN, Tucker LD, Anderson DJ: The molecular basis of nonoxynol-9-induced vaginal inflammation and its possible relevance to human immunodeficiency virus type 1 transmission. J Infect Dis. 2001, 184 (4): 418-428. 10.1086/322047.
Article
CAS
PubMed
Google Scholar
Noguchi K, Tsukumi K, Urano T: Qualitative and quantitative differences in normal vaginal flora of conventionally reared mice, rats, hamsters, rabbits, and dogs. Comparative medicine. 2003, 53 (4): 404-412.
CAS
PubMed
Google Scholar
Costin GE, Raabe HA, Priston R, Evans E, Curren RD: Vaginal irritation models: the current status of available alternative and in vitro tests. Alternatives to laboratory animals: ATLA. 2011, 39 (4): 317-337.
CAS
PubMed
Google Scholar
Eckstein P, Jackson MC, Millman N, Sobrero AJ: Comparison of vaginal tolerance tests of spermicidal preparations in rabbits and monkeys. Journal of reproduction and fertility. 1969, 20 (1): 85-93. 10.1530/jrf.0.0200085.
Article
CAS
PubMed
Google Scholar
Castle PE, Hoen TE, Whaley KJ, Cone RA: Contraceptive testing of vaginal agents in rabbits. Contraception. 1998, 58 (1): 51-60. 10.1016/S0010-7824(98)00059-6.
Article
CAS
PubMed
Google Scholar
Pal S, Fielder TJ, Peterson EM, de la Maza LM: Analysis of the immune response in mice following intrauterine infection with the Chlamydia trachomatis mouse pneumonitis biovar. Infect Immun. 1993, 61 (2): 772-776.
CAS
PubMed
PubMed Central
Google Scholar
Cox F: Prevention of group B streptococcal colonization with topically applied lipoteichoic acid in a maternal-newborn mouse model. Pediatr Res. 1982, 16 (10): 816-819. 10.1203/00006450-198210000-00003.
Article
CAS
PubMed
Google Scholar
Bourne N, Stegall R, Montano R, Meador M, Stanberry LR, Milligan GN: Efficacy and toxicity of zinc salts as candidate topical microbicides against vaginal herpes simplex virus type 2 infection. Antimicrob Agents Chemother. 2005, 49 (3): 1181-1183. 10.1128/AAC.49.3.1181-1183.2005.
Article
CAS
PubMed
PubMed Central
Google Scholar
Milligan GN, Bernstein DI: Interferon-gamma enhances resolution of herpes simplex virus type 2 infection of the murine genital tract. Virology. 1997, 229 (1): 259-268. 10.1006/viro.1997.8441.
Article
CAS
PubMed
Google Scholar
Milligan GN, Chu CF, Young CG, Stanberry LR: Effect of candidate vaginally-applied microbicide compounds on recognition of antigen by CD4+ and CD8+ T lymphocytes. Biol Reprod. 2004, 71 (5): 1638-1645. 10.1095/biolreprod.104.029215.
Article
CAS
PubMed
Google Scholar
Lozenski K, Kish-Catalone T, Pirrone V, Rando RF, Labib M, Wigdahl B, Krebs FC: Cervicovaginal safety of the formulated, biguanide-based human immunodeficiency virus type 1 (HIV-1) inhibitor NB325 in a murine model. Journal of biomedicine & biotechnology. 2011, 2011: 941061-
Article
Google Scholar
Haase AT: Targeting early infection to prevent HIV-1 mucosal transmission. Nature. 2010, 464 (7286): 217-223. 10.1038/nature08757.
Article
CAS
PubMed
Google Scholar
Li Q, Estes JD, Schlievert PM, Duan L, Brosnahan AJ, Southern PJ, Reilly CS, Peterson ML, Schultz-Darken N, Brunner KG: Glycerol monolaurate prevents mucosal SIV transmission. Nature. 2009, 458 (7241): 1034-1038. 10.1038/nature07831.
Article
CAS
PubMed
PubMed Central
Google Scholar
Pudney J, Quayle AJ, Anderson DJ: Immunological microenvironments in the human vagina and cervix: mediators of cellular immunity are concentrated in the cervical transformation zone. Biol Reprod. 2005, 73 (6): 1253-1263. 10.1095/biolreprod.105.043133.
Article
CAS
PubMed
Google Scholar
Cone RA, Hoen T, Wong X, Abusuwwa R, Anderson DJ, Moench TR: Vaginal microbicides: detecting toxicities in vivo that paradoxically increase pathogen transmission. BMC Infect Dis. 2006, 6: 90-10.1186/1471-2334-6-90.
Article
PubMed
PubMed Central
Google Scholar
Grimm MC, Pavli P, Van de Pol E, Doe WF: Evidence for a CD14+ population of monocytes in inflammatory bowel disease mucosa–implications for pathogenesis. Clin Exp Immunol. 1995, 100 (2): 291-297.
Article
CAS
PubMed
PubMed Central
Google Scholar
Clahsen T, Schaper F: Interleukin-6 acts in the fashion of a classical chemokine on monocytic cells by inducing integrin activation, cell adhesion, actin polymerization, chemotaxis, and transmigration. J Leukoc Biol. 2008, 84 (6): 1521-1529. 10.1189/jlb.0308178.
Article
CAS
PubMed
Google Scholar